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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106310
UUCD1 version UUC-SaC-00123
Ensembl Protein ID YHL010C
UniProt Accession P38748; D3DKQ3; Q6Q5F9; ETP1_YEAST
Genbank Protein ID AAB65064.1; AAS56441.1; DAA06676.1
Protein Name RING finger protein ETP1; BRAP2 homolog; Ethanol tolerance protein 1
Genbank Nucleotide ID U11582; AY558115; BK006934
Gene Name ETP1; YHL010C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YHL010C YHL010C YHL010C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/ZnF_UBP ZnF_UBP 16564012
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.80e-09 34.6 240 280
UBD/ZnF/ZnF_UBP 1.90e-28 97.0 300 360
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle++    +g+++ pC+H+fh +Cl+kw        k+ rCP+Cr
   Q: 240  CPVCLERMdseTTGLVTIPCQHTFHCQCLNKW--------KNSRCPVCR 280
           ********666556999***************........9999****8 PP
   

   UBD/ZnF/ZnF_UBP
   S: 2    kcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhplvlslstlsvycYacddyvhr 62
           +c++c++t+nlW+cL+cg+vgCGRy+++Ha+kHyeet h+++++++t++v++Ya+d+yvhr
   Q: 300  HCATCGSTDNLWICLICGNVGCGRYNSKHAIKHYEETLHCFAMDIRTQRVWDYAGDNYVHR 360
           7**********************************************************96 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins.
 May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins.
Protein Sequence
(Fasta)
MDQFEYIITL EFGNQNQVES AYQIFKSIPK KLKAKSIGEE SIKSNNQDWQ DWRVCDLEID 60
MITDFKNQTS KEEESDLITS QYLGHGIIRL FKLSNANNTL NEKEILTIPG DDTMICILFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106310|UBD,ZnF_UBP;E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGATCAAT TTGAGTATAT CATTACTTTA GAATTTGGAA ACCAAAATCA GGTTGAATCC 60
GCTTATCAAA TTTTCAAGAG TATTCCGAAA AAGTTGAAGG CAAAAAGTAT CGGGGAAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106310|UBD,ZnF_UBP;E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011422--BRAP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50089--ZF_RING_2
PS50271--ZF_UBP
Pfam

PF07576--BRAP2
PF13639--zf-RING_2
PF02148--zf-UBP
SMART

SM00184--RING
SM00290--ZnF_UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0008139--F:nuclear localization sequence binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0045471--P:response to ethanol
KEGG sce:YHL010C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000519 Aegilops tauschii 26.23 5.00e-38 150.00
IUUC-Aml-002229 Ailuropoda melanoleuca 33.47 3.00e-63 234.00
IUUC-Atr-002785 Amborella trichopoda 35.26 2.00e-74 271.00
IUUC-Apl-004048 Anas platyrhynchos 33.53 4.00e-64 236.00
IUUC-Aca-005133 Anolis carolinensis 33.13 2.00e-60 224.00
IUUC-Aly-006306 Arabidopsis lyrata 32.03 1.00e-60 224.00
IUUC-Ath-007604 Arabidopsis thaliana 31.31 4.00e-64 236.00
IUUC-Ago-007905 Ashbya gossypii 47.25 3.00e-127 446.00
IUUC-Acl-008310 Aspergillus clavatus 34.05 9.00e-78 282.00
IUUC-Afl-008497 Aspergillus flavus 35.55 1.00e-68 251.00
IUUC-Afu-008830 Aspergillus fumigatus 35.46 1.00e-77 282.00
IUUC-Ani-009485 Aspergillus nidulans 37.01 3.00e-80 290.00
IUUC-Ang-009603 Aspergillus niger 36.51 9.00e-76 275.00
IUUC-Aor-009935 Aspergillus oryzae 35.47 2.00e-76 278.00
IUUC-Ate-010485 Aspergillus terreus 35.23 7.00e-80 289.00
IUUC-Ame-011516 Astyanax mexicanus 32.49 7.00e-60 222.00
IUUC-Bgr-011985 Blumeria graminis 36.34 1.00e-62 232.00
IUUC-Bta-013203 Bos taurus 33.53 4.00e-64 237.00
IUUC-Bci-013788 Botrytis cinerea 39.73 5.00e-69 253.00
IUUC-Bdi-014763 Brachypodium distachyon 31.61 2.00e-60 224.00
IUUC-Bol-015518 Brassica oleracea 33.40 3.00e-64 238.00
IUUC-Bra-017435 Brassica rapa 32.99 1.00e-65 241.00
IUUC-Cel-018194 Caenorhabditis elegans 30.00 2.00e-53 201.00
IUUC-Cja-018948 Callithrix jacchus 31.98 1.00e-62 232.00
IUUC-Cfa-020377 Canis familiaris 31.86 3.00e-65 240.00
IUUC-Cpo-021930 Cavia porcellus 33.13 4.00e-61 226.00
IUUC-Cre-022571 Chlamydomonas reinhardtii 41.87 9.00e-44 168.00
IUUC-Csa-023554 Chlorocebus sabaeus 32.98 2.00e-58 218.00
IUUC-Cin-025326 Ciona intestinalis 30.72 3.00e-54 204.00
IUUC-Csv-026232 Ciona savignyi 31.94 3.00e-60 223.00
IUUC-Cgl-026587 Colletotrichum gloeosporioides 35.98 1.00e-72 265.00
IUUC-Cne-026980 Cryptococcus neoformans 43.21 5.00e-58 216.00
IUUC-Cme-027262 Cyanidioschyzon merolae 30.98 5.00e-54 203.00
IUUC-Dre-028521 Danio rerio 32.21 1.00e-62 232.00
IUUC-Dno-029291 Dasypus novemcinctus 33.07 8.00e-63 232.00
IUUC-Dor-030231 Dipodomys ordii 35.45 3.00e-50 191.00
IUUC-Dse-031234 Dothistroma septosporum 35.10 5.00e-64 236.00
IUUC-Dme-032095 Drosophila melanogaster 31.84 2.00e-64 238.00
IUUC-Ete-032227 Echinops telfairi 50.43 4.00e-36 144.00
IUUC-Eca-034404 Equus caballus 31.69 4.00e-64 237.00
IUUC-Eeu-035030 Erinaceus europaeus 30.73 2.00e-19 88.60
IUUC-Fca-035428 Felis catus 31.97 6.00e-65 239.00
IUUC-Fal-037435 Ficedula albicollis 33.53 3.00e-64 237.00
IUUC-Fox-037733 Fusarium oxysporum 32.74 1.00e-68 252.00
IUUC-Fso-038427 Fusarium solani 32.91 4.00e-69 254.00
IUUC-Gmo-038817 Gadus morhua 32.13 1.00e-61 228.00
IUUC-Ggr-039949 Gaeumannomyces graminis 31.52 7.00e-66 243.00
IUUC-Gga-040929 Gallus gallus 33.33 3.00e-64 237.00
IUUC-Gac-041893 Gasterosteus aculeatus 32.67 2.00e-62 231.00
IUUC-Gma-043119 Glycine max 32.24 1.00e-63 235.00
IUUC-Ggo-045106 Gorilla gorilla 35.81 6.00e-58 216.00
IUUC-Hsa-045685 Homo sapiens 33.73 1.00e-64 238.00
IUUC-Hvu-047475 Hordeum vulgare 31.71 2.00e-34 137.00
IUUC-Itr-048406 Ictidomys tridecemlineatus 32.93 4.00e-61 226.00
IUUC-Kpa-049175 Komagataella pastoris 37.35 7.00e-89 319.00
IUUC-Lch-050408 Latimeria chalumnae 32.54 5.00e-64 236.00
IUUC-Lpe-050777 Leersia perrieri 30.54 4.00e-57 213.00
IUUC-Loc-052160 Lepisosteus oculatus 24.80 2.00e-25 108.00
IUUC-Lma-053095 Leptosphaeria maculans 36.57 7.00e-82 296.00
IUUC-Laf-053497 Loxodonta africana 33.00 1.00e-62 232.00
IUUC-Mcc-055381 Macaca mulatta 33.53 1.00e-63 235.00
IUUC-Meu-056402 Macropus eugenii 25.36 1.00e-21 95.50
IUUC-Mor-057002 Magnaporthe oryzae 34.68 8.00e-69 253.00
IUUC-Mpo-057508 Magnaporthe poae 32.27 1.00e-66 245.00
IUUC-Mtr-058559 Medicago truncatula 32.23 1.00e-59 221.00
IUUC-Mla-058901 Melampsora laricipopulina 33.53 3.00e-72 264.00
IUUC-Mga-059667 Meleagris gallopavo 33.33 5.00e-64 236.00
IUUC-Mvi-060229 Microbotryum violaceum 32.21 2.00e-66 245.00
IUUC-Mmr-060881 Microcebus murinus 33.40 1.00e-59 222.00
IUUC-Mdo-062573 Monodelphis domestica 32.09 6.00e-59 219.00
IUUC-Mmu-063656 Mus musculus 32.67 4.00e-62 230.00
IUUC-Mac-065512 Musa acuminata 32.38 2.00e-60 224.00
IUUC-Mpu-065816 Mustela putorius furo 33.33 8.00e-64 236.00
IUUC-Mlu-067225 Myotis lucifugus 33.33 4.00e-64 237.00
IUUC-Nfi-068534 Neosartorya fischeri 35.46 4.00e-77 280.00
IUUC-Ncr-068801 Neurospora crassa 31.18 6.00e-63 233.00
IUUC-Nle-069258 Nomascus leucogenys 35.66 1.00e-58 218.00
IUUC-Opr-070877 Ochotona princeps 32.74 8.00e-61 226.00
IUUC-Ont-072141 Oreochromis niloticus 31.03 3.00e-60 224.00
IUUC-Oan-072961 Ornithorhynchus anatinus 33.33 9.00e-63 232.00
IUUC-Ocu-074020 Oryctolagus cuniculus 33.10 9.00e-59 220.00
IUUC-Oba-075084 Oryza barthii 32.36 3.00e-59 220.00
IUUC-Obr-076840 Oryza brachyantha 31.50 4.00e-63 233.00
IUUC-Ogl-077482 Oryza glaberrima 31.45 1.00e-58 218.00
IUUC-Ogu-078968 Oryza glumaepatula 32.36 3.00e-59 220.00
IUUC-Oin-079200 Oryza indica 35.48 2.00e-56 211.00
IUUC-Olo-080753 Oryza longistaminata 32.94 2.00e-55 207.00
IUUC-Ome-081756 Oryza meridionalis 31.66 5.00e-59 219.00
IUUC-Oni-082434 Oryza nivara 32.36 3.00e-59 220.00
IUUC-Opu-083262 Oryza punctata 30.87 6.00e-57 213.00
IUUC-Oru-084381 Oryza rufipogon 32.36 3.00e-59 220.00
IUUC-Osa-085498 Oryza sativa 31.66 4.00e-59 220.00
IUUC-Ola-087390 Oryzias latipes 32.99 7.00e-60 223.00
IUUC-Olu-087694 Ostreococcus lucimarinus 27.35 2.00e-48 184.00
IUUC-Oga-088612 Otolemur garnettii 33.13 3.00e-61 227.00
IUUC-Oar-089988 Ovis aries 33.47 1.00e-62 232.00
IUUC-Ptr-090637 Pan troglodytes 33.53 7.00e-64 236.00
IUUC-Pan-092506 Papio anubis 33.53 8.00e-64 236.00
IUUC-Psi-093026 Pelodiscus sinensis 31.04 6.00e-61 226.00
IUUC-Pno-094779 Phaeosphaeria nodorum 31.24 2.00e-59 220.00
IUUC-Ppa-095731 Physcomitrella patens 32.23 3.00e-68 250.00
IUUC-Pfo-096725 Poecilia formosa 35.54 3.00e-58 217.00
IUUC-Pab-098413 Pongo abelii 33.33 3.00e-53 201.00
IUUC-Pop-099070 Populus trichocarpa 32.53 6.00e-64 236.00
IUUC-Pca-100130 Procavia capensis 33.97 6.00e-54 203.00
IUUC-Ppe-101843 Prunus persica 32.58 7.00e-66 242.00
IUUC-Pva-102752 Pteropus vampyrus 33.33 7.00e-64 236.00
IUUC-Pgr-103478 Puccinia graminis 33.83 2.00e-71 261.00
IUUC-Ptt-103921 Puccinia triticina 34.98 4.00e-66 243.00
IUUC-Pte-104032 Pyrenophora teres 34.76 1.00e-81 295.00
IUUC-Pyt-104480 Pyrenophora triticirepentis 35.20 9.00e-80 289.00
IUUC-Rno-106037 Rattus norvegicus 37.76 1.00e-55 208.00
IUUC-Sha-106752 Sarcophilus harrisii 33.33 9.00e-62 229.00
IUUC-Sja-107665 Schizosaccharomyces japonicus 36.64 2.00e-87 313.00
IUUC-Spo-108042 Schizosaccharomyces pombe 34.91 7.00e-72 262.00
IUUC-Ssl-108504 Sclerotinia sclerotiorum 34.62 8.00e-70 256.00
IUUC-Smo-109399 Selaginella moellendorffii 31.30 6.00e-67 246.00
IUUC-Sit-110251 Setaria italica 33.48 9.00e-65 238.00
IUUC-Sly-111563 Solanum lycopersicum 32.26 1.00e-59 221.00
IUUC-Stu-112294 Solanum tuberosum 32.33 2.00e-62 230.00
IUUC-Sar-113080 Sorex araneus 52.43 1.00e-30 124.00
IUUC-Sbi-113915 Sorghum bicolor 30.79 5.00e-59 219.00
IUUC-Sre-114897 Sporisorium reilianum 30.85 7.00e-69 253.00
IUUC-Ssc-115369 Sus scrofa 43.05 3.00e-45 172.00
IUUC-Tgu-116710 Taeniopygia guttata 33.53 2.00e-64 238.00
IUUC-Tru-117941 Takifugu rubripes 31.47 5.00e-60 223.00
IUUC-Tsy-118902 Tarsius syrichta 52.43 7.00e-31 126.00
IUUC-Tni-120587 Tetraodon nigroviridis 31.55 3.00e-62 231.00
IUUC-Tca-121425 Theobroma cacao 31.69 4.00e-63 233.00
IUUC-Tre-121874 Trichoderma reesei 32.57 5.00e-67 247.00
IUUC-Tvi-122266 Trichoderma virens 34.31 2.00e-65 241.00
IUUC-Tae-122790 Triticum aestivum 33.26 1.00e-59 221.00
IUUC-Tur-126467 Triticum urartu 29.91 5.00e-40 156.00
IUUC-Tme-127096 Tuber melanosporum 36.92 1.00e-83 301.00
IUUC-Tbe-128012 Tupaia belangeri 32.48 4.00e-60 223.00
IUUC-Ttr-128388 Tursiops truncatus 33.33 7.00e-64 236.00
IUUC-Uma-129610 Ustilago maydis 41.37 1.00e-60 225.00
IUUC-Vda-129830 Verticillium dahliae 30.74 8.00e-65 239.00
IUUC-Vpa-130171 Vicugna pacos 31.06 9.00e-64 236.00
IUUC-Vvi-131063 Vitis vinifera 34.26 3.00e-60 223.00
IUUC-Xtr-132313 Xenopus tropicalis 32.93 5.00e-65 239.00
IUUC-Xma-133303 Xiphophorus maculatus 31.89 1.00e-59 222.00
IUUC-Yli-134669 Yarrowia lipolytica 36.35 8.00e-91 325.00
IUUC-Zma-135783 Zea mays 30.73 3.00e-60 223.00
Created Date 25-Jun-2017

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