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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045784
UUCD1 version UUC-HoS-00224
Ensembl Protein ID ENSP00000262971.1
UniProt Accession Q8N2W9; O75926; Q96G19; Q9UN16; PIAS4_HUMAN
Genbank Protein ID AAC36703.1; AAH10047.2; AAH29874.1; AAH66895.1; AAD45155.1
Protein Name E3 SUMO-protein ligase PIAS4; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; RING-type E3 ubiquitin transferase PIAS4
Genbank Nucleotide ID AF077952; BC010047; BC029874; BC066895; AF164437
Gene Name PIAS4; PIASG
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105229.6 ENST00000262971.2 ENSP00000262971.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20429939; 19625650; 19450230; 18063693; 17456046; 15713642; 20228053; 16622421; 19615980; 18974227; 17298944; 21079245; 20661221; 20471636; 17696781; 17585876
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.001 21.2 336 369
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 11   gplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           + +   C H   ++C+ ++ ++++n+++++++CP+C+
   Q: 336  PCRAETCAH---LQCFDAVfYLQMNEKKPTWMCPVCD 369
           222333555...555555557899************5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Protein Sequence
(Fasta)
MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 60
LYETRYAKKN SEPAPQPHRP LDPLTMHSTY DRAGAVPRTP LAGPNIDYPV LYGKYLNGLG 120
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Protein Fasta Sequence


>IUUC-Hsa-045784|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAGGAGCGC GCGCGGGTGC TAATTGGCCC GGGCGGCGGC CCCGCCCGCG AGTGGTGAGC 60
GGTCACGTGA CGCGACGGCT GGGGGCTCCC GGCGCGGGGG ACGCTGGTGA CCAAGATGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045784|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027224--PIAS4
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:1990234--C:transferase complex
GO:0003677--F:DNA binding
GO:0061665--F:SUMO ligase activity
GO:0019789--F:SUMO transferase activity
GO:0003714--F:transcription corepressor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902174--P:positive regulation of keratinocyte apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG hsa:51588
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001745 Ailuropoda melanoleuca 92.53 0.00e+00 889.00
IUUC-Apl-003765 Anas platyrhynchos 81.98 0.00e+00 814.00
IUUC-Ame-010763 Astyanax mexicanus 59.78 3.00e-146 511.00
IUUC-Bta-012369 Bos taurus 94.54 0.00e+00 909.00
IUUC-Cja-019450 Callithrix jacchus 97.25 0.00e+00 929.00
IUUC-Cfa-020933 Canis familiaris 93.59 0.00e+00 900.00
IUUC-Cpo-022112 Cavia porcellus 92.41 0.00e+00 868.00
IUUC-Csa-023913 Chlorocebus sabaeus 86.77 0.00e+00 766.00
IUUC-Cgl-026533 Colletotrichum gloeosporioides 27.72 3.00e-34 139.00
IUUC-Dre-027609 Danio rerio 59.01 6.00e-142 497.00
IUUC-Dno-029664 Dasypus novemcinctus 74.88 5.00e-154 538.00
IUUC-Ete-032988 Echinops telfairi 93.06 1.00e-173 602.00
IUUC-Eca-034430 Equus caballus 91.76 0.00e+00 872.00
IUUC-Fca-035968 Felis catus 97.60 3.00e-169 587.00
IUUC-Fal-037449 Ficedula albicollis 83.56 0.00e+00 800.00
IUUC-Fso-038103 Fusarium solani 34.72 1.00e-26 114.00
IUUC-Gmo-038925 Gadus morhua 60.78 3.00e-139 488.00
IUUC-Ggr-039896 Gaeumannomyces graminis 32.48 1.00e-29 124.00
IUUC-Gga-040362 Gallus gallus 85.91 0.00e+00 848.00
IUUC-Gac-042353 Gasterosteus aculeatus 59.05 4.00e-133 468.00
IUUC-Ggo-044810 Gorilla gorilla 97.06 0.00e+00 900.00
IUUC-Itr-048486 Ictidomys tridecemlineatus 90.89 0.00e+00 885.00
IUUC-Lch-049727 Latimeria chalumnae 72.22 9.00e-153 533.00
IUUC-Loc-052354 Lepisosteus oculatus 53.71 3.00e-122 431.00
IUUC-Laf-054261 Loxodonta africana 92.82 0.00e+00 906.00
IUUC-Mcc-054931 Macaca mulatta 98.82 0.00e+00 933.00
IUUC-Meu-056468 Macropus eugenii 87.48 0.00e+00 867.00
IUUC-Mpo-057405 Magnaporthe poae 33.06 1.00e-28 121.00
IUUC-Mga-059981 Meleagris gallopavo 89.09 0.00e+00 709.00
IUUC-Mvi-060421 Microbotryum violaceum 29.22 2.00e-27 117.00
IUUC-Mmr-061181 Microcebus murinus 92.09 0.00e+00 870.00
IUUC-Mdo-062345 Monodelphis domestica 87.28 0.00e+00 869.00
IUUC-Mmu-063197 Mus musculus 86.80 0.00e+00 853.00
IUUC-Mpu-066275 Mustela putorius furo 92.22 0.00e+00 899.00
IUUC-Mlu-067194 Myotis lucifugus 93.79 0.00e+00 903.00
IUUC-Ncr-068929 Neurospora crassa 27.70 3.00e-27 116.00
IUUC-Ont-072227 Oreochromis niloticus 59.05 7.00e-139 487.00
IUUC-Obr-076179 Oryza brachyantha 42.86 2.00e-20 94.70
IUUC-Ola-086865 Oryzias latipes 58.78 5.00e-138 484.00
IUUC-Oga-088945 Otolemur garnettii 95.89 0.00e+00 934.00
IUUC-Oar-089412 Ovis aries 91.99 0.00e+00 869.00
IUUC-Ptr-091550 Pan troglodytes 87.11 0.00e+00 652.00
IUUC-Pan-092183 Papio anubis 99.02 0.00e+00 948.00
IUUC-Psi-093003 Pelodiscus sinensis 83.95 0.00e+00 830.00
IUUC-Pfo-096704 Poecilia formosa 59.10 5.00e-141 494.00
IUUC-Pab-097923 Pongo abelii 99.74 0.00e+00 783.00
IUUC-Pca-100249 Procavia capensis 76.58 2.00e-143 501.00
IUUC-Pva-102562 Pteropus vampyrus 89.48 0.00e+00 836.00
IUUC-Rno-105762 Rattus norvegicus 87.38 0.00e+00 857.00
IUUC-Sce-106398 Saccharomyces cerevisiae 34.10 1.00e-28 121.00
IUUC-Sha-107253 Sarcophilus harrisii 86.50 0.00e+00 860.00
IUUC-Sja-107662 Schizosaccharomyces japonicus 31.41 7.00e-29 122.00
IUUC-Sar-113149 Sorex araneus 85.82 1.00e-127 450.00
IUUC-Ssc-115241 Sus scrofa 94.15 0.00e+00 914.00
IUUC-Tgu-116884 Taeniopygia guttata 84.33 0.00e+00 803.00
IUUC-Tru-118031 Takifugu rubripes 59.50 7.00e-145 507.00
IUUC-Tni-119766 Tetraodon nigroviridis 59.46 5.00e-140 491.00
IUUC-Ttr-128556 Tursiops truncatus 84.14 0.00e+00 738.00
IUUC-Xtr-131866 Xenopus tropicalis 77.22 0.00e+00 763.00
IUUC-Xma-133963 Xiphophorus maculatus 59.37 5.00e-135 474.00
Created Date 25-Jun-2017

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