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Tag Content
UUCD2 ID IUUC-Ocu-074176
UUCD1 version UUC-OrC-01003
Ensembl Protein ID ENSOCUP00000006868.3
UniProt Accession G1SU51; G1SU51_RABIT
Genbank Protein ID ENSOCUP00000006868
Protein Name Ubiquitin carboxyl-terminal hydrolase
Genbank Nucleotide ID AAGW02044171
Gene Name BAP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000007946.3 ENSOCUT00000007948.3 ENSOCUP00000006868.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/UCH 1.30e-169 564.1 3 728
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/UCH
   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr+++++rl+vlk++         
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRIKYEARLHVLKVNrqtvlealq 260
           *************************************..************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qlirvtqpeliqthksqesqlpeeskpssgkspvgleasrasaapdgthtdgvedvagscpqalahsppgkpklvvkppgsslngvppt 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  papivqrlpafldnhnyakspmqeeedlaagvgrsrvpvrpphqysddeddyeddeedevqntnsairykrkgpgkpgplsgsadgqls 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vlqpntinvlaeklkesqkdlsvplsiktssgagspavavpahsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshi 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  skvlfgeddsllrvdcirynravrdlgpvistgllhladdgvlsplaltesgkgsspsvrpsqgsqgssspeekevvettdsrektgla 616
           ***************************************************************************************** PP
   S: 260  .............keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvn 335
                        keLl+Llk++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l++lve++is++r++gv+
   Q: 617  rpgeplsgekyspKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVS 705
           ***************************************************************************************** PP
   S: 336  egrlakqrkqgrekkirplkrkr 358
           +grl+kqrk++r+k++rp+k+kr
   Q: 706  IGRLHKQRKPDRRKRSRPYKAKR 728
           *********************98 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074176|DUB,UCH|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATAAGG GCTGGCTGGA GCTGGAGAGC GATCCGGGTG AGGAGGGGGC CGGGTGGGCC 60
AGGGACTGGG GAGGCCGTAT GGGCTTGGGA TGCCCCTGCC TGACCACCCC CCGCGTCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074176|DUB,UCH|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001263 Ailuropoda melanoleuca 94.02 0.00e+00 1204.00
IUUC-Apl-003405 Anas platyrhynchos 69.61 0.00e+00 630.00
IUUC-Aca-004836 Anolis carolinensis 79.26 0.00e+00 1130.00
IUUC-Ame-011946 Astyanax mexicanus 63.89 0.00e+00 879.00
IUUC-Bta-013131 Bos taurus 90.96 0.00e+00 1060.00
IUUC-Cja-019599 Callithrix jacchus 95.06 0.00e+00 1293.00
IUUC-Cfa-021003 Canis familiaris 95.47 0.00e+00 1197.00
IUUC-Cpo-022143 Cavia porcellus 94.51 0.00e+00 1273.00
IUUC-Csa-023477 Chlorocebus sabaeus 95.20 0.00e+00 1270.00
IUUC-Cho-024734 Choloepus hoffmanni 81.64 0.00e+00 737.00
IUUC-Csv-025842 Ciona savignyi 57.33 5.00e-94 337.00
IUUC-Dre-027793 Danio rerio 65.03 0.00e+00 908.00
IUUC-Dno-029253 Dasypus novemcinctus 94.29 0.00e+00 1258.00
IUUC-Dor-030891 Dipodomys ordii 87.38 0.00e+00 1172.00
IUUC-Dme-031796 Drosophila melanogaster 61.19 1.00e-91 330.00
IUUC-Ete-032646 Echinops telfairi 86.99 4.00e-169 588.00
IUUC-Eca-033805 Equus caballus 94.79 0.00e+00 1251.00
IUUC-Eeu-035216 Erinaceus europaeus 94.90 1.00e-144 506.00
IUUC-Fca-035611 Felis catus 95.40 0.00e+00 1152.00
IUUC-Fal-037186 Ficedula albicollis 79.42 0.00e+00 993.00
IUUC-Gmo-038824 Gadus morhua 69.85 0.00e+00 627.00
IUUC-Gga-040875 Gallus gallus 81.23 0.00e+00 1103.00
IUUC-Gac-042226 Gasterosteus aculeatus 67.44 0.00e+00 928.00
IUUC-Ggo-045122 Gorilla gorilla 94.79 0.00e+00 1296.00
IUUC-Hsa-045882 Homo sapiens 94.79 0.00e+00 1295.00
IUUC-Itr-048185 Ictidomys tridecemlineatus 95.88 0.00e+00 1280.00
IUUC-Lch-049960 Latimeria chalumnae 72.36 0.00e+00 998.00
IUUC-Loc-052408 Lepisosteus oculatus 76.43 0.00e+00 658.00
IUUC-Laf-054187 Loxodonta africana 95.20 0.00e+00 1242.00
IUUC-Mcc-055273 Macaca mulatta 94.24 0.00e+00 1266.00
IUUC-Meu-056267 Macropus eugenii 82.17 0.00e+00 1150.00
IUUC-Mga-059958 Meleagris gallopavo 87.58 2.00e-153 534.00
IUUC-Mmr-061280 Microcebus murinus 95.07 0.00e+00 1246.00
IUUC-Mdo-062625 Monodelphis domestica 88.48 0.00e+00 1254.00
IUUC-Mmu-063853 Mus musculus 92.59 0.00e+00 1264.00
IUUC-Mlu-067771 Myotis lucifugus 94.79 0.00e+00 1238.00
IUUC-Opr-070741 Ochotona princeps 95.06 0.00e+00 1294.00
IUUC-Ont-072172 Oreochromis niloticus 66.49 0.00e+00 936.00
IUUC-Oan-073167 Ornithorhynchus anatinus 79.48 0.00e+00 1128.00
IUUC-Ola-087203 Oryzias latipes 85.23 5.00e-134 470.00
IUUC-Oga-089153 Otolemur garnettii 94.46 0.00e+00 1253.00
IUUC-Oar-090008 Ovis aries 91.91 0.00e+00 1221.00
IUUC-Ptr-091234 Pan troglodytes 95.06 0.00e+00 1301.00
IUUC-Pan-092005 Papio anubis 95.20 0.00e+00 1294.00
IUUC-Psi-093995 Pelodiscus sinensis 84.42 0.00e+00 654.00
IUUC-Pma-094110 Petromyzon marinus 77.12 1.00e-64 241.00
IUUC-Pfo-097418 Poecilia formosa 65.53 0.00e+00 922.00
IUUC-Pab-098267 Pongo abelii 95.20 0.00e+00 1276.00
IUUC-Pca-101084 Procavia capensis 93.28 0.00e+00 1202.00
IUUC-Pva-102292 Pteropus vampyrus 95.15 0.00e+00 902.00
IUUC-Rno-105251 Rattus norvegicus 91.11 0.00e+00 1237.00
IUUC-Sha-107100 Sarcophilus harrisii 87.22 0.00e+00 1250.00
IUUC-Sar-113559 Sorex araneus 85.61 0.00e+00 1060.00
IUUC-Ssc-115688 Sus scrofa 94.79 0.00e+00 1274.00
IUUC-Tgu-117424 Taeniopygia guttata 79.78 0.00e+00 1116.00
IUUC-Tru-118585 Takifugu rubripes 67.30 0.00e+00 919.00
IUUC-Tsy-119299 Tarsius syrichta 83.21 0.00e+00 948.00
IUUC-Tni-120808 Tetraodon nigroviridis 66.80 0.00e+00 914.00
IUUC-Tbe-127705 Tupaia belangeri 94.09 1.00e-178 618.00
IUUC-Ttr-128225 Tursiops truncatus 94.24 0.00e+00 1226.00
IUUC-Vpa-130193 Vicugna pacos 95.67 1.00e-130 460.00
IUUC-Xtr-132449 Xenopus tropicalis 70.75 0.00e+00 933.00
Created Date 25-Jun-2017

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