iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.60e-42	139.9	62	98
UBD/Beta-Prp	4.60e-65	220.1	57	263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sd..tllvsGsdDgtikvWDlrt 32
           gHt++v+++ f   ++  +l +++sdDgt+k+WD+ t
   Q: 62   GHTERVSGFTFshhPGqyNLCATSSDDGTVKIWDVET 98
           8************9666799**************976 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcl 129
           + +l gh++ v+  +fs++     + +t+s+D+t+k+wd++t   v     h++++ +l++sp+  d +vsG++  ++ ++   +++ +
   Q: 57   VGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKIWDVETKAVVTEHALHQHTISALHWSPTVkDLIVSGDEKGVVFCYW-LNRSDS 144
           78999*************965677***************************************655**************95.555555 PP
   S: 130  eetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.ktgkllrtltgghtdsvyslsfdsng......................... 192
           ++++++ +++ + ++++  +nl++ G +D++v + d+ k g+++++l+g h+d ++s+++ + +                         
   Q: 145  QHLFTEPRAIFCLTCSPHHENLVAIGYKDGIVIIIDIsKKGEVVHRLRG-HDDEIHSIAWCPLSgedclsinqeenseepdipngklia 232
           52566555555555555555*****************999********9.*********666666667777778899999********* PP
   S: 193  .......kelvsgsldgtvklwdlqtgecvr 216
                   +l++gs+d+t+++w++++g+ v+
   Q: 233  etpitkgCYLATGSKDQTIRIWSCSRGRGVM 263
           *****99******************987665 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MKPEPRTLPP SPNWYCARCS DAAPGGIFGF AARTSVFLVR VGPGAGASPG APPFRVVGEL 60
VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKA VVTEHALHQH TISALHWSPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGATCCCGC CCCCTCCCGC TACACGCCGC GGTTGCGAAC CACCGTACCG GAGCTCCTCG 60
GCTGAGCCTC GGCGGCCGCG GAGATGAAAC CAGAGCCGCG GACGCTTCCG CCGTCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0022625--C:cytosolic large ribosomal subunit
GO:0016020--C:membrane
GO:0016604--C:nuclear body
GO:0032797--C:SMN complex
GO:0034718--C:SMN-Gemin2 complex
GO:0034719--C:SMN-Sm protein complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0043022--F:ribosome binding
GO:0000340--F:RNA 7-methylguanosine cap binding
GO:0030619--F:U1 snRNA binding
GO:0030621--F:U4 snRNA binding
GO:0030622--F:U4atac snRNA binding
GO:0006417--P:regulation of translation
GO:0000387--P:spliceosomal snRNP assembly

KEGG

rno:691231

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001199	Ailuropoda melanoleuca	82.04	0.00e+00	2431.00
IUUC-Apl-003586	Anas platyrhynchos	60.59	0.00e+00	1590.00
IUUC-Aca-004956	Anolis carolinensis	62.08	0.00e+00	1852.00
IUUC-Ame-010753	Astyanax mexicanus	61.68	0.00e+00	994.00
IUUC-Bta-012315	Bos taurus	80.58	0.00e+00	2414.00
IUUC-Cja-019334	Callithrix jacchus	81.22	0.00e+00	2452.00
IUUC-Cfa-021254	Canis familiaris	81.82	0.00e+00	2479.00
IUUC-Cpo-021984	Cavia porcellus	78.75	0.00e+00	2233.00
IUUC-Csa-023650	Chlorocebus sabaeus	82.01	0.00e+00	2434.00
IUUC-Cho-024860	Choloepus hoffmanni	77.01	0.00e+00	2228.00
IUUC-Cin-025778	Ciona intestinalis	40.91	3.00e-157	549.00
IUUC-Csv-026313	Ciona savignyi	40.29	2.00e-162	566.00
IUUC-Dre-028096	Danio rerio	62.48	0.00e+00	996.00
IUUC-Dno-029799	Dasypus novemcinctus	83.44	0.00e+00	2138.00
IUUC-Dor-030885	Dipodomys ordii	71.39	0.00e+00	1065.00
IUUC-Ete-032918	Echinops telfairi	76.58	0.00e+00	2244.00
IUUC-Eca-034144	Equus caballus	81.12	0.00e+00	2361.00
IUUC-Eeu-034843	Erinaceus europaeus	75.04	0.00e+00	1705.00
IUUC-Fca-035948	Felis catus	82.40	0.00e+00	2430.00
IUUC-Fal-037303	Ficedula albicollis	60.90	0.00e+00	1770.00
IUUC-Gmo-039591	Gadus morhua	53.02	0.00e+00	834.00
IUUC-Gga-040570	Gallus gallus	61.66	0.00e+00	1609.00
IUUC-Gac-042646	Gasterosteus aculeatus	48.42	0.00e+00	1344.00
IUUC-Ggo-045605	Gorilla gorilla	76.44	0.00e+00	1757.00
IUUC-Hsa-046122	Homo sapiens	82.27	0.00e+00	2438.00
IUUC-Itr-048094	Ictidomys tridecemlineatus	86.71	0.00e+00	2199.00
IUUC-Lch-050489	Latimeria chalumnae	48.06	0.00e+00	832.00
IUUC-Loc-052259	Lepisosteus oculatus	60.39	0.00e+00	956.00
IUUC-Laf-053338	Loxodonta africana	80.50	0.00e+00	2399.00
IUUC-Mcc-055442	Macaca mulatta	82.14	0.00e+00	2437.00
IUUC-Meu-056245	Macropus eugenii	80.70	0.00e+00	851.00
IUUC-Mga-060202	Meleagris gallopavo	62.23	0.00e+00	1686.00
IUUC-Mmr-061730	Microcebus murinus	82.51	0.00e+00	2427.00
IUUC-Mdo-062880	Monodelphis domestica	70.87	0.00e+00	2103.00
IUUC-Mmu-063930	Mus musculus	95.68	0.00e+00	2686.00
IUUC-Mpu-066605	Mustela putorius furo	81.26	0.00e+00	2427.00
IUUC-Mlu-067765	Myotis lucifugus	82.40	0.00e+00	2464.00
IUUC-Nle-069183	Nomascus leucogenys	82.14	0.00e+00	2393.00
IUUC-Opr-070659	Ochotona princeps	71.14	0.00e+00	1071.00
IUUC-Ont-072356	Oreochromis niloticus	61.07	0.00e+00	1003.00
IUUC-Oan-073056	Ornithorhynchus anatinus	67.88	0.00e+00	1921.00
IUUC-Ocu-073881	Oryctolagus cuniculus	82.49	0.00e+00	2492.00
IUUC-Ola-087120	Oryzias latipes	56.04	1.00e-66	245.00
IUUC-Olu-087648	Ostreococcus lucimarinus	24.81	1.00e-30	129.00
IUUC-Oga-088343	Otolemur garnettii	82.48	0.00e+00	2466.00
IUUC-Oar-089257	Ovis aries	80.83	0.00e+00	2423.00
IUUC-Ptr-090497	Pan troglodytes	82.14	0.00e+00	2407.00
IUUC-Pan-092638	Papio anubis	82.15	0.00e+00	2432.00
IUUC-Psi-093096	Pelodiscus sinensis	62.75	0.00e+00	1592.00
IUUC-Pma-094571	Petromyzon marinus	42.70	3.00e-81	295.00
IUUC-Pfo-096348	Poecilia formosa	61.59	0.00e+00	972.00
IUUC-Pab-098153	Pongo abelii	81.81	0.00e+00	2445.00
IUUC-Pca-100957	Procavia capensis	75.27	0.00e+00	2242.00
IUUC-Pva-102439	Pteropus vampyrus	82.03	0.00e+00	2459.00
IUUC-Sha-107181	Sarcophilus harrisii	70.74	0.00e+00	2011.00
IUUC-Ssc-115413	Sus scrofa	80.66	0.00e+00	2451.00
IUUC-Tgu-117082	Taeniopygia guttata	62.19	0.00e+00	1763.00
IUUC-Tru-118491	Takifugu rubripes	59.16	0.00e+00	946.00
IUUC-Tsy-119629	Tarsius syrichta	79.30	0.00e+00	763.00
IUUC-Tni-120240	Tetraodon nigroviridis	58.90	0.00e+00	942.00
IUUC-Tbe-127673	Tupaia belangeri	71.95	0.00e+00	1979.00
IUUC-Ttr-128562	Tursiops truncatus	78.30	0.00e+00	2336.00
IUUC-Vpa-130596	Vicugna pacos	79.39	0.00e+00	1758.00
IUUC-Xtr-132469	Xenopus tropicalis	56.90	0.00e+00	1633.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence