iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	2.10e-06	28.0	102	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++ + l++ GFd++ ++qaL+ + n ++eaAve++ 
   Q: 102  NPQMFQDLQAAGFDEDMVIQALQKTnNRSIEAAVEFIS 139
           67899*******************99*********975 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MKRGEKPEGY RQMRPKTFPA SNYSGSSRQM LQEIRESLRN LSKPSDAAKA EHNLNKMSTE 60
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETSSSRIPSE VNPQMFQDLQ AAGFDEDMVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCAAAATG GCGGCGGCAG CGATGGCCTG GTGCTGAGGG AGAGCCAGGT CCTCGCGACC 60
CCGCGTCGGG CCGCGCTGGC CGGCCGCAGC CCCCCGGCGT CTGTCCCCGC CCTGCCCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0046620--P:regulation of organ growth
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation

KEGG

rno:308265

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	92.84	0.00e+00	1939.00
IUUC-Apl-003278	Anas platyrhynchos	82.35	0.00e+00	1771.00
IUUC-Aca-005319	Anolis carolinensis	80.55	0.00e+00	1710.00
IUUC-Ame-011324	Astyanax mexicanus	66.75	0.00e+00	1317.00
IUUC-Bta-013438	Bos taurus	92.74	0.00e+00	1899.00
IUUC-Cel-018517	Caenorhabditis elegans	50.11	3.00e-129	456.00
IUUC-Cja-019072	Callithrix jacchus	93.27	0.00e+00	1968.00
IUUC-Cfa-021267	Canis familiaris	92.57	0.00e+00	1956.00
IUUC-Cpo-021496	Cavia porcellus	88.59	0.00e+00	1640.00
IUUC-Csa-023255	Chlorocebus sabaeus	93.89	0.00e+00	1961.00
IUUC-Cho-024461	Choloepus hoffmanni	97.32	0.00e+00	776.00
IUUC-Cin-025264	Ciona intestinalis	63.94	2.00e-141	495.00
IUUC-Dre-028034	Danio rerio	80.50	0.00e+00	934.00
IUUC-Dno-029888	Dasypus novemcinctus	89.74	0.00e+00	1940.00
IUUC-Dor-030144	Dipodomys ordii	83.20	0.00e+00	1653.00
IUUC-Dme-031656	Drosophila melanogaster	73.43	0.00e+00	655.00
IUUC-Ete-032813	Echinops telfairi	92.21	0.00e+00	1209.00
IUUC-Eca-033781	Equus caballus	92.83	0.00e+00	1921.00
IUUC-Eeu-035007	Erinaceus europaeus	89.39	0.00e+00	1905.00
IUUC-Fca-036142	Felis catus	88.23	0.00e+00	1833.00
IUUC-Fal-036626	Ficedula albicollis	82.27	0.00e+00	1768.00
IUUC-Gmo-038688	Gadus morhua	86.22	0.00e+00	785.00
IUUC-Gga-040553	Gallus gallus	83.66	0.00e+00	1790.00
IUUC-Gac-042031	Gasterosteus aculeatus	64.06	0.00e+00	1271.00
IUUC-Ggo-045242	Gorilla gorilla	93.64	0.00e+00	1959.00
IUUC-Hsa-046081	Homo sapiens	93.54	0.00e+00	1956.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	93.18	0.00e+00	1663.00
IUUC-Lch-049425	Latimeria chalumnae	77.28	0.00e+00	1664.00
IUUC-Loc-052418	Lepisosteus oculatus	66.78	0.00e+00	1352.00
IUUC-Laf-053710	Loxodonta africana	91.25	0.00e+00	1926.00
IUUC-Mcc-055079	Macaca mulatta	93.63	0.00e+00	1956.00
IUUC-Mga-059713	Meleagris gallopavo	82.98	0.00e+00	1784.00
IUUC-Mmr-061728	Microcebus murinus	92.93	0.00e+00	1964.00
IUUC-Mdo-061942	Monodelphis domestica	86.12	0.00e+00	1789.00
IUUC-Mmu-063504	Mus musculus	96.19	0.00e+00	1976.00
IUUC-Mpu-066034	Mustela putorius furo	92.83	0.00e+00	1932.00
IUUC-Mlu-067986	Myotis lucifugus	90.88	0.00e+00	1917.00
IUUC-Nle-069202	Nomascus leucogenys	93.63	0.00e+00	1960.00
IUUC-Opr-070801	Ochotona princeps	93.33	0.00e+00	1269.00
IUUC-Ont-072487	Oreochromis niloticus	61.09	0.00e+00	1235.00
IUUC-Oan-073128	Ornithorhynchus anatinus	85.66	0.00e+00	1580.00
IUUC-Ocu-073998	Oryctolagus cuniculus	92.73	0.00e+00	1399.00
IUUC-Ola-086858	Oryzias latipes	59.70	0.00e+00	1177.00
IUUC-Oga-088874	Otolemur garnettii	91.35	0.00e+00	1886.00
IUUC-Oar-089236	Ovis aries	92.31	0.00e+00	1895.00
IUUC-Ptr-091425	Pan troglodytes	93.72	0.00e+00	1961.00
IUUC-Pan-091851	Papio anubis	93.73	0.00e+00	1958.00
IUUC-Psi-093825	Pelodiscus sinensis	83.32	0.00e+00	1462.00
IUUC-Pfo-096326	Poecilia formosa	61.35	0.00e+00	1179.00
IUUC-Pab-097815	Pongo abelii	93.72	0.00e+00	1961.00
IUUC-Pva-102836	Pteropus vampyrus	91.50	0.00e+00	1847.00
IUUC-Ptt-103762	Puccinia triticina	37.98	3.00e-93	336.00
IUUC-Sha-106843	Sarcophilus harrisii	86.43	0.00e+00	1833.00
IUUC-Sar-113649	Sorex araneus	90.94	0.00e+00	1507.00
IUUC-Ssc-115486	Sus scrofa	95.00	0.00e+00	840.00
IUUC-Tgu-116903	Taeniopygia guttata	82.44	0.00e+00	1753.00
IUUC-Tru-118760	Takifugu rubripes	64.56	0.00e+00	1286.00
IUUC-Tsy-119361	Tarsius syrichta	92.51	0.00e+00	1672.00
IUUC-Tni-120058	Tetraodon nigroviridis	59.87	0.00e+00	1157.00
IUUC-Tbe-127681	Tupaia belangeri	92.33	0.00e+00	1528.00
IUUC-Ttr-128652	Tursiops truncatus	91.99	0.00e+00	1604.00
IUUC-Vpa-130538	Vicugna pacos	91.42	0.00e+00	1891.00
IUUC-Xtr-132895	Xenopus tropicalis	71.96	0.00e+00	1271.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence