iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135924.15	ENST00000336576.9	ENSP00000338019.5
ENSG00000135924.15	ENST00000392086.8	ENSP00000375936.4
ENSG00000135924.15	ENST00000421532.5	ENSP00000395173.1
ENSG00000135924.15	ENST00000392087.6	ENSP00000375937.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	15936278
UBD/Alpha-Helix/DUIM	DUIM	16462748

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/DUIM	0.0015	20.0	250	267
UBD/Alpha-Helix/UIM	0.62	2.8	210	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/DUIM

   S: 1    dEdeeLqlAlalSlqEee 18
           +Ede+LqlA+a Sl+E+e
   Q: 250  SEDEDLQLAMAYSLSEME 267
           7***************98 PP

UBD/Alpha-Helix/UIM

   S: 4    eeLqlAlalSlqEeee 19
           ++L+l l+lS+ E++ 
   Q: 210  DDLALGLELSRREQQP 225
           689999*******975 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PARK2, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).

Protein Sequence
(Fasta)

MASYYEILDV PRSASADDIK KAYRRKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 60
KREIYDRYGR EGLTGTGTGP SRAEAGSGGP GFTFTFRSPE EVFREFFGSG DPFAELFDDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGCCCAA AATAGCCGGC TCCGCCCTCT TCTCCCGGCA GCCCCTGCAG GCCCCCACCC 60
CCCCAGGGGA CAGGCGGAGC CGGCCTTCTC CCCGTCTCTA GTAGTTTCCG CACCGCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR001623--DnaJ_domain
IPR018253--DnaJ_domain_CS
IPR003903--UIM_dom

PROSITE

PS00636--DNAJ_1
PS50076--DNAJ_2
PS50330--UIM

Pfam

PF00226--DnaJ
PF02809--UIM

PRINTS

PR00625--JDOMAIN

SMART

SM00271--DnaJ
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016234--C:inclusion body
GO:0031227--C:intrinsic component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0001671--F:ATPase activator activity
GO:0051087--F:chaperone binding
GO:0030544--F:Hsp70 protein binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0051082--F:unfolded protein binding
GO:0061077--P:chaperone-mediated protein folding
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0090084--P:negative regulation of inclusion body assembly
GO:0032091--P:negative regulation of protein binding
GO:0090086--P:negative regulation of protein deubiquitination
GO:0032781--P:positive regulation of ATPase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042026--P:protein refolding
GO:1903644--P:regulation of chaperone-mediated protein folding
GO:0032880--P:regulation of protein localization
GO:0031396--P:regulation of protein ubiquitination
GO:0006986--P:response to unfolded protein
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:3300

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001535	Ailuropoda melanoleuca	91.69	1.00e-115	409.00
IUUC-Cja-019459	Callithrix jacchus	96.03	1.00e-111	396.00
IUUC-Cpo-022195	Cavia porcellus	88.92	4.00e-132	464.00
IUUC-Cho-024785	Choloepus hoffmanni	85.85	1.00e-118	419.00
IUUC-Dor-030267	Dipodomys ordii	86.42	2.00e-131	461.00
IUUC-Fal-037220	Ficedula albicollis	59.07	5.00e-70	257.00
IUUC-Gmo-038998	Gadus morhua	54.55	1.00e-52	199.00
IUUC-Gga-041119	Gallus gallus	64.37	2.00e-68	252.00
IUUC-Itr-047899	Ictidomys tridecemlineatus	91.40	1.00e-96	345.00
IUUC-Lch-050678	Latimeria chalumnae	56.90	2.00e-69	255.00
IUUC-Loc-052924	Lepisosteus oculatus	55.97	4.00e-68	251.00
IUUC-Laf-053924	Loxodonta africana	90.12	1.00e-99	355.00
IUUC-Meu-056813	Macropus eugenii	65.15	4.00e-53	201.00
IUUC-Mla-058991	Melampsora laricipopulina	42.86	1.10e+00	28.10
IUUC-Mga-059404	Meleagris gallopavo	58.76	3.00e-66	245.00
IUUC-Mdo-061987	Monodelphis domestica	61.59	1.00e-71	263.00
IUUC-Mmu-064407	Mus musculus	85.19	1.00e-108	386.00
IUUC-Mpu-066202	Mustela putorius furo	90.15	7.00e-114	403.00
IUUC-Mlu-067902	Myotis lucifugus	85.85	9.00e-129	452.00
IUUC-Nle-069173	Nomascus leucogenys	85.76	6.00e-120	423.00
IUUC-Oga-089055	Otolemur garnettii	91.69	1.00e-129	455.00
IUUC-Oar-090400	Ovis aries	90.12	5.00e-119	420.00
IUUC-Ptr-091562	Pan troglodytes	100.00	1.00e-144	506.00
IUUC-Pab-098730	Pongo abelii	100.00	7.00e-115	406.00
IUUC-Pca-100425	Procavia capensis	90.46	1.00e-107	383.00
IUUC-Sha-107349	Sarcophilus harrisii	59.70	4.00e-80	291.00
IUUC-Ssc-115552	Sus scrofa	91.69	7.00e-107	380.00
IUUC-Tgu-116678	Taeniopygia guttata	62.68	3.00e-66	244.00
IUUC-Tni-120479	Tetraodon nigroviridis	55.12	1.00e-48	186.00
IUUC-Tbe-127946	Tupaia belangeri	80.80	6.00e-82	297.00
IUUC-Ttr-128304	Tursiops truncatus	89.54	7.00e-114	403.00
IUUC-Vpa-130308	Vicugna pacos	72.97	4.00e-23	102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence