iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090508

Ensembl Protein ID

ENSPTRP00000029736.4

UniProt Accession

H2QRS0; H2QRS0_PANTR

Genbank Protein ID

ENSPTRP00000029736

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03039229

Gene Name

ARHGEF37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000017402.5	ENSPTRT00000032190.4	ENSPTRP00000029736.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-10	41.3	605	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++ y++ a ++ e +l++G  v+++  ++++ + +W     e +g+rG +P+ F ++++
   Q: 605  NQVIAAYPFVARSSHEVSLQAGQPVTILeaQDKKGNPEWSLV--EVNGQRGYVPSGFLARAR 664
           7899************************9889999****977..9************99875 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAKHGADEPS SRSGSPDGEG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL 60
QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGGCGGC CGACCTCCGT GCGTGAGCGC CGGCAGGCAC CTTGCGCGCG CGGGTGAGTC 60
CGCTGGGCGT TTGGGGCCTG GTCAAGCAGG ATGGGGCTGG AGAGGGGTGC AGGAAACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF00621--RhoGEF
PF00018--SH3_1
PF07653--SH3_2

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002128	Ailuropoda melanoleuca	29.20	3.00e-66	247.00
IUUC-Apl-003698	Anas platyrhynchos	32.10	1.00e-80	293.00
IUUC-Aca-005005	Anolis carolinensis	29.43	7.00e-67	249.00
IUUC-Ame-011907	Astyanax mexicanus	39.75	2.00e-129	456.00
IUUC-Bta-012848	Bos taurus	86.07	0.00e+00	1118.00
IUUC-Cel-018396	Caenorhabditis elegans	24.03	1.00e-21	99.80
IUUC-Cja-019104	Callithrix jacchus	27.58	3.00e-55	211.00
IUUC-Cfa-021281	Canis familiaris	84.74	0.00e+00	1095.00
IUUC-Cpo-022440	Cavia porcellus	30.00	4.00e-66	247.00
IUUC-Csa-023043	Chlorocebus sabaeus	96.44	0.00e+00	1281.00
IUUC-Cho-024795	Choloepus hoffmanni	36.02	3.00e-29	124.00
IUUC-Dre-028496	Danio rerio	39.81	1.00e-126	447.00
IUUC-Dno-029750	Dasypus novemcinctus	29.37	1.00e-65	245.00
IUUC-Dor-031109	Dipodomys ordii	28.41	3.00e-62	234.00
IUUC-Ete-032921	Echinops telfairi	62.50	1.00e-71	262.00
IUUC-Eca-033433	Equus caballus	30.46	5.00e-67	250.00
IUUC-Eeu-034929	Erinaceus europaeus	31.60	1.00e-38	155.00
IUUC-Fca-035859	Felis catus	29.49	1.00e-66	248.00
IUUC-Fal-036653	Ficedula albicollis	29.03	4.00e-61	230.00
IUUC-Gmo-038948	Gadus morhua	28.10	2.00e-66	248.00
IUUC-Gga-040279	Gallus gallus	29.32	1.00e-65	245.00
IUUC-Gac-041641	Gasterosteus aculeatus	30.05	4.00e-71	263.00
IUUC-Ggo-044900	Gorilla gorilla	98.81	0.00e+00	1302.00
IUUC-Hsa-045684	Homo sapiens	98.67	0.00e+00	1337.00
IUUC-Itr-049071	Ictidomys tridecemlineatus	29.04	1.00e-60	229.00
IUUC-Lch-050096	Latimeria chalumnae	46.24	4.00e-169	587.00
IUUC-Loc-051937	Lepisosteus oculatus	42.33	8.00e-135	474.00
IUUC-Laf-054037	Loxodonta africana	28.81	4.00e-63	237.00
IUUC-Mcc-054950	Macaca mulatta	95.70	0.00e+00	1272.00
IUUC-Meu-056383	Macropus eugenii	69.23	9.00e-173	600.00
IUUC-Mga-059868	Meleagris gallopavo	29.02	4.00e-62	234.00
IUUC-Mmr-060767	Microcebus murinus	30.00	2.00e-64	241.00
IUUC-Mdo-062021	Monodelphis domestica	68.21	0.00e+00	883.00
IUUC-Mmu-064186	Mus musculus	78.99	0.00e+00	1023.00
IUUC-Mpu-065913	Mustela putorius furo	29.49	5.00e-67	250.00
IUUC-Mlu-067340	Myotis lucifugus	30.31	8.00e-65	242.00
IUUC-Nle-069343	Nomascus leucogenys	29.37	1.00e-64	242.00
IUUC-Opr-070694	Ochotona princeps	28.06	3.00e-59	224.00
IUUC-Ont-071844	Oreochromis niloticus	28.62	3.00e-69	257.00
IUUC-Ocu-074406	Oryctolagus cuniculus	29.37	1.00e-64	242.00
IUUC-Ola-087343	Oryzias latipes	31.45	5.00e-87	315.00
IUUC-Oga-088847	Otolemur garnettii	29.88	1.00e-64	242.00
IUUC-Oar-089817	Ovis aries	29.97	8.00e-66	246.00
IUUC-Pan-092517	Papio anubis	96.15	0.00e+00	1249.00
IUUC-Pma-094663	Petromyzon marinus	29.24	8.00e-52	199.00
IUUC-Pfo-096703	Poecilia formosa	39.63	1.00e-124	440.00
IUUC-Pab-098542	Pongo abelii	98.67	0.00e+00	1297.00
IUUC-Pca-101096	Procavia capensis	35.10	4.00e-28	120.00
IUUC-Pva-102490	Pteropus vampyrus	28.55	1.00e-62	235.00
IUUC-Rno-105455	Rattus norvegicus	80.77	0.00e+00	1054.00
IUUC-Sha-106562	Sarcophilus harrisii	69.66	0.00e+00	871.00
IUUC-Ssc-115250	Sus scrofa	29.32	3.00e-66	247.00
IUUC-Tru-118279	Takifugu rubripes	30.03	2.00e-75	278.00
IUUC-Tni-120459	Tetraodon nigroviridis	32.37	2.00e-92	332.00
IUUC-Ttr-128242	Tursiops truncatus	82.22	0.00e+00	1077.00
IUUC-Vpa-130643	Vicugna pacos	27.70	3.00e-55	211.00
IUUC-Xtr-131979	Xenopus tropicalis	28.92	1.00e-64	242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence