iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067522

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02055914

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000003428.2	ENSMLUT00000003426.2	ENSMLUP00000003116.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.30e-107	358.1	531	857

Active Site

Position(s)	Description	Evidence
826	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+en k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 531  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDENTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 614
           689********************************************9998877.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p l++slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 615  HFPMVVYRKLMGKKGTFRDLGDSHPVLFQSLKDLLEY-EGSVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 701
           *************************************.6677775.999**9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggy++ds  i+ Fw+++++f++e+++ fLq
   Q: 702  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYSRDSALIREFWDIVHAFTEEQKRLFLQ 790
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 791  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 857
           *****************...8888866666**************************************97 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

CQRMATACKR SPGEPQSDDT EASRMKRAAA KHLIERYYHQ LTEGCGNEAC TNECCASCPS 60
FLRMDNNAAA IKALELYKVN AKLCDPHPSK KGASSAYLEN AKGAANSCSD VKMNKKDGLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCAACGAA TGGCCACAGC TTGTAAAAGG TAATTTTGAA CGTTACTTTA CAGCCGTAGG 60
GGCTGTCGTA GAGCGACGTG CGGGCTGGAA ACACGAGGAC AGTGTCTGGT TGGTGGGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	89.53	0.00e+00	1488.00
IUUC-Atr-003144	Amborella trichopoda	47.03	4.00e-95	341.00
IUUC-Apl-003742	Anas platyrhynchos	86.50	0.00e+00	1487.00
IUUC-Aca-004873	Anolis carolinensis	86.95	0.00e+00	1484.00
IUUC-Ame-011166	Astyanax mexicanus	82.06	0.00e+00	1367.00
IUUC-Bta-013286	Bos taurus	89.44	0.00e+00	1504.00
IUUC-Cja-019707	Callithrix jacchus	89.16	0.00e+00	1501.00
IUUC-Cfa-020154	Canis familiaris	89.84	0.00e+00	1514.00
IUUC-Cpo-021292	Cavia porcellus	88.82	0.00e+00	1474.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	4.00e-82	297.00
IUUC-Csa-023378	Chlorocebus sabaeus	89.23	0.00e+00	1512.00
IUUC-Cho-025059	Choloepus hoffmanni	85.02	0.00e+00	1390.00
IUUC-Cin-025643	Ciona intestinalis	42.21	0.00e+00	674.00
IUUC-Csv-026282	Ciona savignyi	42.70	0.00e+00	635.00
IUUC-Cme-027151	Cyanidioschyzon merolae	45.28	2.00e-98	354.00
IUUC-Dre-027901	Danio rerio	81.58	0.00e+00	1353.00
IUUC-Dno-029320	Dasypus novemcinctus	88.89	0.00e+00	1518.00
IUUC-Dor-030756	Dipodomys ordii	97.02	0.00e+00	668.00
IUUC-Dme-032035	Drosophila melanogaster	40.56	3.00e-151	529.00
IUUC-Eca-033843	Equus caballus	89.30	0.00e+00	1464.00
IUUC-Eeu-035109	Erinaceus europaeus	87.89	0.00e+00	1435.00
IUUC-Fca-036344	Felis catus	90.03	0.00e+00	1527.00
IUUC-Fal-036747	Ficedula albicollis	86.57	0.00e+00	1481.00
IUUC-Gmo-038840	Gadus morhua	61.28	0.00e+00	1040.00
IUUC-Gga-040399	Gallus gallus	86.57	0.00e+00	1480.00
IUUC-Gac-041933	Gasterosteus aculeatus	79.64	0.00e+00	1313.00
IUUC-Ggo-044804	Gorilla gorilla	88.95	0.00e+00	1501.00
IUUC-Hsa-045727	Homo sapiens	88.95	0.00e+00	1501.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	85.45	0.00e+00	1392.00
IUUC-Lch-050197	Latimeria chalumnae	84.14	0.00e+00	1439.00
IUUC-Loc-052743	Lepisosteus oculatus	84.77	0.00e+00	1438.00
IUUC-Lma-053245	Leptosphaeria maculans	33.60	6.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	86.34	0.00e+00	1469.00
IUUC-Mcc-054934	Macaca mulatta	89.23	0.00e+00	1498.00
IUUC-Meu-056061	Macropus eugenii	82.33	0.00e+00	1301.00
IUUC-Mga-059271	Meleagris gallopavo	84.99	0.00e+00	1441.00
IUUC-Mmr-061288	Microcebus murinus	88.77	0.00e+00	1495.00
IUUC-Mdo-062975	Monodelphis domestica	87.78	0.00e+00	1495.00
IUUC-Mmu-063674	Mus musculus	87.17	0.00e+00	1468.00
IUUC-Mpu-066568	Mustela putorius furo	89.80	0.00e+00	1535.00
IUUC-Nle-069505	Nomascus leucogenys	88.95	0.00e+00	1501.00
IUUC-Opr-070570	Ochotona princeps	83.35	0.00e+00	1348.00
IUUC-Ont-071527	Oreochromis niloticus	81.27	0.00e+00	1382.00
IUUC-Oan-073446	Ornithorhynchus anatinus	83.61	0.00e+00	953.00
IUUC-Ocu-074922	Oryctolagus cuniculus	89.19	0.00e+00	1514.00
IUUC-Ola-086996	Oryzias latipes	79.39	0.00e+00	1373.00
IUUC-Oga-088261	Otolemur garnettii	88.72	0.00e+00	1471.00
IUUC-Oar-090024	Ovis aries	89.44	0.00e+00	1504.00
IUUC-Ptr-090455	Pan troglodytes	88.95	0.00e+00	1501.00
IUUC-Pan-092509	Papio anubis	86.77	0.00e+00	1337.00
IUUC-Psi-092974	Pelodiscus sinensis	86.94	0.00e+00	1463.00
IUUC-Pma-094643	Petromyzon marinus	68.68	0.00e+00	1185.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.58	3.00e-58	220.00
IUUC-Pfo-096905	Poecilia formosa	79.93	0.00e+00	1375.00
IUUC-Pab-097840	Pongo abelii	87.11	0.00e+00	1434.00
IUUC-Pca-100869	Procavia capensis	88.17	0.00e+00	1456.00
IUUC-Pva-103040	Pteropus vampyrus	96.13	0.00e+00	662.00
IUUC-Rno-105453	Rattus norvegicus	86.72	0.00e+00	1462.00
IUUC-Sha-107651	Sarcophilus harrisii	87.78	0.00e+00	1495.00
IUUC-Smo-108858	Selaginella moellendorffii	40.58	2.00e-117	416.00
IUUC-Sar-113293	Sorex araneus	89.30	0.00e+00	1486.00
IUUC-Ssc-115979	Sus scrofa	89.17	0.00e+00	1484.00
IUUC-Tgu-116901	Taeniopygia guttata	86.50	0.00e+00	1487.00
IUUC-Tru-118368	Takifugu rubripes	80.94	0.00e+00	1386.00
IUUC-Tsy-119516	Tarsius syrichta	84.77	0.00e+00	1361.00
IUUC-Tni-120143	Tetraodon nigroviridis	80.85	0.00e+00	1384.00
IUUC-Tbe-127484	Tupaia belangeri	82.22	0.00e+00	986.00
IUUC-Ttr-129078	Tursiops truncatus	89.07	0.00e+00	1476.00
IUUC-Vpa-130312	Vicugna pacos	81.44	0.00e+00	1258.00
IUUC-Xtr-132881	Xenopus tropicalis	84.83	0.00e+00	1446.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence