iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134373

Ensembl Protein ID

CAG79952

UniProt Accession

Q6C4Q9; ATG3_YARLI

Genbank Protein ID

CAG79952.1

Protein Name

Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme ATG3

Genbank Nucleotide ID

CR382131

Gene Name

ATG3; YALI0E24453g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E24453g	CAG79952	CAG79952

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	30.96	5.00e-29	125.00	IUUC-Ath-006802
E2/Autophagy_C	35.92	2.00e-18	91.30	IUUC-Hsa-046449
E2/Autophagy_C	42.19	6.00e-61	229.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
287	Glycyl thioester intermediate	{ECO:0000250}

Organism

Yarrowia lipolytica

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).

Protein Sequence
(Fasta)

MEAHKGKQDI FIVQVLITPT FVELNHIYPP IRLLSPPSIS SNPSIKFDKT QAPPTLFIYI 60
ASYNTPDYQT TLHKSTMLHV RAAASSLREY LTPVSNTSTF RTTGEITPDE FVKAGDYLVE 120

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Nucleotide Sequence
(Fasta)

ATGGAAGCAC ACAAAGGGAA GCAAGATATT TTCATAGTAC AAGTACTTAT AACCCCGACA 60
TTTGTCGAAT TAAACCACAT ATATCCTCCC ATTCGCCTTC TGTCACCTCC CTCTATCTCC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0000153--C:cytoplasmic ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006612--P:protein targeting to membrane

KEGG

yli:YALI0E24453g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	38.10	5.00e-13	66.20
IUUC-Aml-002081	Ailuropoda melanoleuca	37.32	8.00e-21	92.00
IUUC-Atr-002712	Amborella trichopoda	27.00	1.00e-22	98.20
IUUC-Apl-003956	Anas platyrhynchos	43.66	2.00e-12	64.30
IUUC-Aca-004578	Anolis carolinensis	46.08	8.00e-21	92.00
IUUC-Aly-005823	Arabidopsis lyrata	30.96	1.00e-30	124.00
IUUC-Ath-006802	Arabidopsis thaliana	30.96	7.00e-31	125.00
IUUC-Ago-007855	Ashbya gossypii	48.79	2.00e-69	253.00
IUUC-Acl-008147	Aspergillus clavatus	37.99	3.00e-47	180.00
IUUC-Afl-008483	Aspergillus flavus	37.82	8.00e-52	195.00
IUUC-Afu-008818	Aspergillus fumigatus	44.00	6.00e-35	139.00
IUUC-Ani-009481	Aspergillus nidulans	39.46	4.00e-30	123.00
IUUC-Ang-009800	Aspergillus niger	42.06	3.00e-55	206.00
IUUC-Aor-010150	Aspergillus oryzae	37.82	8.00e-52	195.00
IUUC-Ate-010545	Aspergillus terreus	40.22	2.00e-30	123.00
IUUC-Ame-011793	Astyanax mexicanus	37.32	5.00e-21	92.80
IUUC-Bgr-012167	Blumeria graminis	38.72	4.00e-51	192.00
IUUC-Bta-012695	Bos taurus	37.32	7.00e-21	92.40
IUUC-Bci-013972	Botrytis cinerea	49.23	1.00e-24	104.00
IUUC-Bdi-014756	Brachypodium distachyon	38.19	9.00e-20	88.60
IUUC-Bol-015091	Brassica oleracea	34.03	2.00e-16	77.80
IUUC-Bra-017220	Brassica rapa	30.03	1.00e-30	124.00
IUUC-Cel-018143	Caenorhabditis elegans	48.98	6.00e-21	92.40
IUUC-Cja-018991	Callithrix jacchus	37.32	8.00e-21	92.00
IUUC-Cfa-020070	Canis familiaris	37.32	7.00e-21	92.40
IUUC-Cpo-021860	Cavia porcellus	47.92	8.00e-21	92.00
IUUC-Cre-022948	Chlamydomonas reinhardtii	35.42	3.00e-22	96.70
IUUC-Csa-023881	Chlorocebus sabaeus	37.32	8.00e-21	92.00
IUUC-Cho-024852	Choloepus hoffmanni	37.32	9.00e-21	92.00
IUUC-Cin-025787	Ciona intestinalis	36.62	4.00e-22	96.30
IUUC-Csv-026369	Ciona savignyi	36.62	2.00e-22	97.10
IUUC-Cgl-026680	Colletotrichum gloeosporioides	44.19	2.00e-35	140.00
IUUC-Cne-026905	Cryptococcus neoformans	51.19	7.00e-22	96.30
IUUC-Dre-028811	Danio rerio	47.92	4.00e-21	93.20
IUUC-Dno-030081	Dasypus novemcinctus	37.32	9.00e-21	92.00
IUUC-Dor-030183	Dipodomys ordii	46.88	4.00e-20	90.10
IUUC-Dse-031539	Dothistroma septosporum	38.93	4.00e-19	86.70
IUUC-Dme-031805	Drosophila melanogaster	47.13	6.00e-21	92.40
IUUC-Ete-033171	Echinops telfairi	38.03	3.00e-21	93.20
IUUC-Eca-034083	Equus caballus	37.32	7.00e-21	92.40
IUUC-Eeu-034804	Erinaceus europaeus	36.62	4.00e-20	89.70
IUUC-Fca-036289	Felis catus	37.32	8.00e-21	92.00
IUUC-Fal-037060	Ficedula albicollis	47.92	6.00e-21	92.40
IUUC-Fox-038051	Fusarium oxysporum	40.75	2.00e-55	207.00
IUUC-Fso-038124	Fusarium solani	43.42	2.00e-23	100.00
IUUC-Gmo-039538	Gadus morhua	47.92	5.00e-21	92.80
IUUC-Ggr-039880	Gaeumannomyces graminis	44.64	5.00e-35	139.00
IUUC-Gga-041108	Gallus gallus	47.92	5.00e-21	92.80
IUUC-Gac-041558	Gasterosteus aculeatus	36.34	1.00e-39	154.00
IUUC-Gma-043969	Glycine max	34.72	8.00e-17	79.00
IUUC-Ggo-045071	Gorilla gorilla	37.32	8.00e-21	92.00
IUUC-Hsa-046449	Homo sapiens	37.32	8.00e-21	92.00
IUUC-Hvu-047451	Hordeum vulgare	34.27	2.00e-18	84.30
IUUC-Itr-048360	Ictidomys tridecemlineatus	37.32	8.00e-21	92.00
IUUC-Kpa-049096	Komagataella pastoris	49.52	3.00e-73	266.00
IUUC-Lch-049726	Latimeria chalumnae	45.83	3.00e-21	93.60
IUUC-Lpe-050734	Leersia perrieri	40.91	5.00e-16	76.30
IUUC-Loc-051983	Lepisosteus oculatus	46.88	6.00e-21	92.40
IUUC-Lma-053038	Leptosphaeria maculans	38.11	4.00e-49	186.00
IUUC-Laf-054510	Loxodonta africana	37.32	7.00e-21	92.40
IUUC-Mcc-054792	Macaca mulatta	37.32	8.00e-21	92.00
IUUC-Meu-055965	Macropus eugenii	34.51	2.00e-17	80.90
IUUC-Mor-057292	Magnaporthe oryzae	41.26	6.00e-56	209.00
IUUC-Mtr-058282	Medicago truncatula	30.82	3.00e-32	130.00
IUUC-Mla-059144	Melampsora laricipopulina	38.73	1.00e-20	91.70
IUUC-Mga-059509	Meleagris gallopavo	47.92	5.00e-21	92.80
IUUC-Mvi-060281	Microbotryum violaceum	54.55	2.00e-20	91.30
IUUC-Mmr-061788	Microcebus murinus	37.32	8.00e-21	92.00
IUUC-Mdo-062922	Monodelphis domestica	37.32	9.00e-21	92.00
IUUC-Mmu-064249	Mus musculus	47.92	6.00e-21	92.40
IUUC-Mac-064474	Musa acuminata	35.42	1.00e-18	84.70
IUUC-Mpu-065717	Mustela putorius furo	37.32	8.00e-21	92.00
IUUC-Mlu-067151	Myotis lucifugus	35.92	7.00e-18	82.00
IUUC-Nfi-068551	Neosartorya fischeri	40.17	3.00e-56	209.00
IUUC-Ncr-068846	Neurospora crassa	41.33	3.00e-54	203.00
IUUC-Nle-069790	Nomascus leucogenys	37.32	8.00e-21	92.00
IUUC-Ont-072517	Oreochromis niloticus	37.32	5.00e-21	92.80
IUUC-Oan-073285	Ornithorhynchus anatinus	37.32	7.00e-21	91.70
IUUC-Ocu-074695	Oryctolagus cuniculus	37.32	7.00e-21	92.40
IUUC-Oba-074991	Oryza barthii	31.41	4.00e-32	129.00
IUUC-Obr-076787	Oryza brachyantha	36.36	1.00e-19	88.20
IUUC-Ogl-077440	Oryza glaberrima	37.06	5.00e-20	89.40
IUUC-Ogu-078294	Oryza glumaepatula	37.06	4.00e-20	89.70
IUUC-Oin-079452	Oryza indica	37.06	4.00e-20	89.70
IUUC-Olo-080450	Oryza longistaminata	31.41	5.00e-32	129.00
IUUC-Ome-081514	Oryza meridionalis	37.06	5.00e-20	89.70
IUUC-Oni-082677	Oryza nivara	37.06	4.00e-20	89.70
IUUC-Opu-083925	Oryza punctata	37.06	5.00e-20	89.40
IUUC-Oru-084828	Oryza rufipogon	31.51	4.00e-32	129.00
IUUC-Osa-085937	Oryza sativa	40.91	7.00e-16	75.90
IUUC-Ola-086559	Oryzias latipes	48.96	4.00e-22	95.90
IUUC-Olu-087766	Ostreococcus lucimarinus	30.48	2.00e-34	136.00
IUUC-Oga-087983	Otolemur garnettii	37.32	7.00e-21	92.40
IUUC-Oar-089281	Ovis aries	37.32	7.00e-21	92.40
IUUC-Ptr-090983	Pan troglodytes	37.32	8.00e-21	92.00
IUUC-Pan-092457	Papio anubis	37.32	7.00e-21	92.40
IUUC-Psi-094046	Pelodiscus sinensis	36.62	2.00e-20	90.50
IUUC-Pno-094925	Phaeosphaeria nodorum	37.79	2.00e-50	191.00
IUUC-Ppa-095487	Physcomitrella patens	34.69	9.00e-17	78.60
IUUC-Pfo-096968	Poecilia formosa	47.92	4.00e-21	93.20
IUUC-Pab-098621	Pongo abelii	46.88	4.00e-20	89.70
IUUC-Pop-100007	Populus trichocarpa	30.65	3.00e-30	123.00
IUUC-Pca-100590	Procavia capensis	37.32	8.00e-21	92.00
IUUC-Ppe-101657	Prunus persica	30.38	7.00e-30	122.00
IUUC-Pva-102446	Pteropus vampyrus	37.32	7.00e-21	92.40
IUUC-Pgr-103604	Puccinia graminis	52.00	2.00e-19	88.20
IUUC-Ptt-103941	Puccinia triticina	48.31	3.00e-19	87.40
IUUC-Pte-104252	Pyrenophora teres	39.31	2.00e-51	194.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	38.26	3.00e-51	193.00
IUUC-Rno-106025	Rattus norvegicus	37.32	8.00e-21	92.00
IUUC-Sce-106172	Saccharomyces cerevisiae	42.68	1.00e-60	224.00
IUUC-Sha-106858	Sarcophilus harrisii	37.32	8.00e-21	92.00
IUUC-Sja-107905	Schizosaccharomyces japonicus	33.97	2.00e-37	147.00
IUUC-Spo-108185	Schizosaccharomyces pombe	60.00	4.00e-20	89.40
IUUC-Smo-108883	Selaginella moellendorffii	31.61	1.00e-29	121.00
IUUC-Sit-110512	Setaria italica	37.76	3.00e-20	90.50
IUUC-Sly-111238	Solanum lycopersicum	29.64	2.00e-29	120.00
IUUC-Stu-112441	Solanum tuberosum	30.12	2.00e-29	120.00
IUUC-Sar-113039	Sorex araneus	37.32	7.00e-21	92.00
IUUC-Sbi-113776	Sorghum bicolor	37.06	9.00e-19	85.50
IUUC-Sre-115074	Sporisorium reilianum	52.33	2.00e-22	98.20
IUUC-Ssc-115262	Sus scrofa	37.32	8.00e-21	92.00
IUUC-Tgu-116790	Taeniopygia guttata	38.03	4.00e-21	93.20
IUUC-Tru-118160	Takifugu rubripes	50.00	5.00e-22	96.30
IUUC-Tsy-119145	Tarsius syrichta	55.32	3.00e-10	57.00
IUUC-Tni-119937	Tetraodon nigroviridis	30.03	3.00e-29	119.00
IUUC-Tca-121323	Theobroma cacao	29.91	2.00e-29	120.00
IUUC-Tre-121993	Trichoderma reesei	40.94	3.00e-30	123.00
IUUC-Tvi-122332	Trichoderma virens	45.61	1.00e-30	124.00
IUUC-Tae-124391	Triticum aestivum	35.66	2.00e-19	87.80
IUUC-Tur-126679	Triticum urartu	35.66	2.00e-19	87.80
IUUC-Tme-127159	Tuber melanosporum	42.59	4.00e-18	82.80
IUUC-Ttr-128261	Tursiops truncatus	37.32	7.00e-21	92.00
IUUC-Uma-129572	Ustilago maydis	48.57	1.00e-23	102.00
IUUC-Vda-129966	Verticillium dahliae	42.43	2.00e-56	210.00
IUUC-Vpa-130698	Vicugna pacos	37.32	9.00e-21	92.00
IUUC-Vvi-131240	Vitis vinifera	29.76	2.00e-05	40.80
IUUC-Xtr-132878	Xenopus tropicalis	37.32	4.00e-21	93.20
IUUC-Xma-134017	Xiphophorus maculatus	47.92	3.00e-21	93.60
IUUC-Zma-135222	Zea mays	37.06	1.00e-18	85.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence