iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088771

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03154526

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000028141.1	ENSOGAT00000027304.1	ENSOGAP00000021949.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-90	304.1	176	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 176  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 260
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 261  DAHEFLIAALDVLHRHCKG----------------DDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 333
           *****************22................2344668899999****************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 334  CTSFWPmspgressvngeshisgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 420
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 421  TTYISFPLELDMTPFMASskesrmngqlqlPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 507
           ******************5555555555554444444**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 508  -SEGYLLFYHKQ 518
           .********985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

VGPPGCSHVN SFKVGENWRQ ELRVIYQCFV WCGTPETRKS KAKSCICHVC GTHLNRLHSC 60
LFCVFFGCFT EKHIHEHAET KQHNLAVDLY YGGIYCFMCK DYVYDKDIEQ IAKEEQGEAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGACCCCGA CCCCGGCCCC AGACCCGGCT CCGTACCCCA CCTCAGCCTA GGCCACGGCC 60
CCCGCCCCGG CCCCGGCCCC GGCGCGGCCC TGGGGGTGGA TGCCTGGATG TGGATTTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	97.13	0.00e+00	1061.00
IUUC-Aly-006565	Arabidopsis lyrata	36.36	2.00e-73	270.00
IUUC-Ath-007536	Arabidopsis thaliana	35.96	1.00e-73	270.00
IUUC-Bta-012659	Bos taurus	97.72	0.00e+00	900.00
IUUC-Bol-016509	Brassica oleracea	36.49	2.00e-73	270.00
IUUC-Bra-016962	Brassica rapa	35.50	3.00e-72	265.00
IUUC-Cja-019954	Callithrix jacchus	90.65	0.00e+00	989.00
IUUC-Cfa-020956	Canis familiaris	98.25	0.00e+00	1059.00
IUUC-Cpo-022014	Cavia porcellus	97.32	0.00e+00	1064.00
IUUC-Csa-023350	Chlorocebus sabaeus	98.86	0.00e+00	909.00
IUUC-Dno-029905	Dasypus novemcinctus	97.95	0.00e+00	900.00
IUUC-Dor-030832	Dipodomys ordii	97.41	1.00e-111	396.00
IUUC-Eca-033957	Equus caballus	96.56	0.00e+00	1051.00
IUUC-Fca-035768	Felis catus	96.75	0.00e+00	1058.00
IUUC-Gma-043933	Glycine max	36.07	9.00e-89	320.00
IUUC-Ggo-044925	Gorilla gorilla	97.32	0.00e+00	1062.00
IUUC-Hsa-045775	Homo sapiens	99.09	0.00e+00	911.00
IUUC-Itr-048775	Ictidomys tridecemlineatus	99.09	0.00e+00	911.00
IUUC-Laf-053947	Loxodonta africana	96.18	0.00e+00	1053.00
IUUC-Mmr-061013	Microcebus murinus	98.63	0.00e+00	906.00
IUUC-Mpu-066433	Mustela putorius furo	96.75	0.00e+00	1058.00
IUUC-Mlu-067330	Myotis lucifugus	95.98	0.00e+00	1047.00
IUUC-Nle-069084	Nomascus leucogenys	99.09	0.00e+00	911.00
IUUC-Ocu-074951	Oryctolagus cuniculus	94.84	0.00e+00	1042.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.61	1.00e-49	190.00
IUUC-Oar-089610	Ovis aries	97.67	0.00e+00	1056.00
IUUC-Pan-092253	Papio anubis	99.03	0.00e+00	1068.00
IUUC-Pab-098324	Pongo abelii	97.32	0.00e+00	1062.00
IUUC-Pca-100329	Procavia capensis	95.98	0.00e+00	1048.00
IUUC-Pva-102721	Pteropus vampyrus	91.78	0.00e+00	984.00
IUUC-Smo-109310	Selaginella moellendorffii	36.07	1.00e-88	320.00
IUUC-Stu-112203	Solanum tuberosum	38.98	3.00e-76	278.00
IUUC-Sar-113174	Sorex araneus	92.81	0.00e+00	958.00
IUUC-Sre-115195	Sporisorium reilianum	27.50	3.00e-53	203.00
IUUC-Ssc-115315	Sus scrofa	98.66	0.00e+00	1086.00
IUUC-Tsy-119413	Tarsius syrichta	72.85	0.00e+00	764.00
IUUC-Tca-121154	Theobroma cacao	37.29	1.00e-92	333.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence