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Tag Content
iUUCD ID IUUC-Cfa-020505
Ensembl Protein ID ENSCAFP00000012403.4
UniProt Accession F1P937; F1P937_CANLF
Genbank Protein ID ENSCAFP00000012403
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AAEX03013680
Gene Name ERICH6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000008436.4 ENSCAFT00000049773.2 ENSCAFP00000040642.1
ENSCAFG00000008436.4 ENSCAFT00000013398.3 ENSCAFP00000012398.3
ENSCAFG00000008436.4 ENSCAFT00000013403.4 ENSCAFP00000012403.4
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 99.61 5.00e-153 538.00 IUUC-Hsa-046179
E3 activity/RING/RING 99.61 1.00e-152 536.00 IUUC-Mmu-063206
E3 activity/RING/RING 99.61 9.00e-153 536.00 IUUC-Rno-105477
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Canis familiaris
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
XXSKPCSKPP PPQHAPSPAA PPAAATISAA GPGSAAVPAA AAVISGPGGG GGGGGGGGAG 60
PVSPQHHELT SLFECPVCFD YVLPPILQCQ AGHLVCNQCR QKLSCCPTCR GALTPSIRNL 120
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Protein Fasta Sequence


>IUUC-Cfa-020505|E3,RING|Canis familiaris
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Nucleotide Sequence
(Fasta)
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNTAG CAAGCCGTGC 60
AGCAAGCCGC CGCCGCCCCA GCACGCCCCG TCCCCGGCTG CGCCCCCGGC CGCCGCCACC 120
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Nucleotide Fasta Sequence


>IUUC-Cfa-020505|E3,RING|Canis familiaris
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH
PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH
Pfam

PF03145--Sina
Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001409 Ailuropoda melanoleuca 99.61 1.00e-155 542.00
IUUC-Ame-011678 Astyanax mexicanus 91.70 6.00e-141 493.00
IUUC-Bta-012750 Bos taurus 99.22 8.00e-154 536.00
IUUC-Cja-019800 Callithrix jacchus 99.61 5.00e-154 536.00
IUUC-Cpo-021394 Cavia porcellus 98.84 3.00e-153 534.00
IUUC-Csa-023374 Chlorocebus sabaeus 99.61 5.00e-154 536.00
IUUC-Cho-024933 Choloepus hoffmanni 99.61 4.00e-154 536.00
IUUC-Dre-027711 Danio rerio 91.30 8.00e-141 493.00
IUUC-Dno-029260 Dasypus novemcinctus 99.59 1.00e-147 515.00
IUUC-Dor-030489 Dipodomys ordii 96.76 1.00e-107 381.00
IUUC-Ete-032946 Echinops telfairi 98.84 5.00e-156 543.00
IUUC-Eca-033546 Equus caballus 99.22 3.00e-155 540.00
IUUC-Eeu-034861 Erinaceus europaeus 95.74 4.00e-148 517.00
IUUC-Fal-037160 Ficedula albicollis 88.05 2.00e-132 464.00
IUUC-Gmo-039091 Gadus morhua 90.12 2.00e-139 488.00
IUUC-Gga-040252 Gallus gallus 97.67 2.00e-151 528.00
IUUC-Gac-041673 Gasterosteus aculeatus 89.33 3.00e-139 487.00
IUUC-Ggo-044618 Gorilla gorilla 99.61 5.00e-154 536.00
IUUC-Hsa-046179 Homo sapiens 99.61 5.00e-154 536.00
IUUC-Itr-048976 Ictidomys tridecemlineatus 98.45 6.00e-154 536.00
IUUC-Lch-049496 Latimeria chalumnae 95.33 3.00e-149 520.00
IUUC-Loc-052107 Lepisosteus oculatus 92.40 5.00e-141 493.00
IUUC-Laf-054257 Loxodonta africana 99.22 4.00e-153 533.00
IUUC-Mcc-055023 Macaca mulatta 99.61 5.00e-154 536.00
IUUC-Meu-055922 Macropus eugenii 97.65 2.00e-149 521.00
IUUC-Mga-060070 Meleagris gallopavo 96.11 7.00e-148 516.00
IUUC-Mmr-061494 Microcebus murinus 99.61 5.00e-154 536.00
IUUC-Mdo-061971 Monodelphis domestica 99.22 2.00e-153 534.00
IUUC-Mmu-063206 Mus musculus 99.61 1.00e-153 535.00
IUUC-Mpu-066597 Mustela putorius furo 99.61 5.00e-154 536.00
IUUC-Mlu-067199 Myotis lucifugus 99.22 2.00e-153 535.00
IUUC-Nle-069342 Nomascus leucogenys 99.61 5.00e-154 536.00
IUUC-Opr-070341 Ochotona princeps 56.86 5.00e-50 190.00
IUUC-Ont-071906 Oreochromis niloticus 89.72 4.00e-140 490.00
IUUC-Oan-073701 Ornithorhynchus anatinus 53.85 1.00e-49 189.00
IUUC-Ocu-073950 Oryctolagus cuniculus 99.23 6.00e-156 543.00
IUUC-Oga-089154 Otolemur garnettii 99.61 5.00e-154 536.00
IUUC-Oar-089446 Ovis aries 98.47 4.00e-156 543.00
IUUC-Ptr-091088 Pan troglodytes 99.61 5.00e-154 536.00
IUUC-Psi-093079 Pelodiscus sinensis 98.86 3.00e-158 550.00
IUUC-Pfo-097007 Poecilia formosa 85.77 2.00e-133 468.00
IUUC-Pab-098092 Pongo abelii 99.61 5.00e-154 536.00
IUUC-Pca-100328 Procavia capensis 96.47 6.00e-148 516.00
IUUC-Pva-102368 Pteropus vampyrus 99.11 1.00e-63 236.00
IUUC-Rno-105477 Rattus norvegicus 99.61 1.00e-153 535.00
IUUC-Sha-107630 Sarcophilus harrisii 99.24 2.00e-158 551.00
IUUC-Ssc-116441 Sus scrofa 99.22 7.00e-154 536.00
IUUC-Tru-118004 Takifugu rubripes 86.96 2.00e-134 471.00
IUUC-Tsy-119548 Tarsius syrichta 88.72 6.00e-67 246.00
IUUC-Tni-120846 Tetraodon nigroviridis 88.54 6.00e-137 479.00
IUUC-Vpa-130799 Vicugna pacos 98.84 2.00e-103 367.00
Created Date 25-Jun-2017

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