iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089446

Ensembl Protein ID

ENSOARP00000004657.1

UniProt Accession

W5P2K7; W5P2K7_SHEEP

Genbank Protein ID

ENSOARP00000004657

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AMGL01010867

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000004352.1	ENSOART00000004738.1	ENSOARP00000004657.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.85	1.00e-155	546.00	IUUC-Hsa-046179
E3 activity/RING/RING	98.46	3.00e-154	541.00	IUUC-Mmu-063206
E3 activity/RING/RING	98.85	3.00e-155	544.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ovis aries

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

ALAGPMLPQH HELTSLFECP VCFDYVLPPI LQCQAGHLVC NQCRQKLSCC PTCRGALTPS 60
IRNLAMEKVA SAVLFPCKYA TTGCSLTLHH TEKPEHEDIC EYRPYSCPCP GASCKWQGSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTGGCAG GGCCAATGGT AAAAGACTAG TTTACCTCCT TTCCCCCTGG GAAGAGCAGG 60
ACCAAAGAGT GGTCCAAACA TATCCTTAAC ATCCCAGCAC TCCAAAGCTC CGGGTCTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	99.61	4.00e-154	537.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	5.00e-141	493.00
IUUC-Bta-012750	Bos taurus	100.00	7.00e-154	536.00
IUUC-Cja-019800	Callithrix jacchus	99.61	2.00e-153	535.00
IUUC-Cfa-020505	Canis familiaris	99.22	1.00e-152	532.00
IUUC-Cpo-021394	Cavia porcellus	99.22	1.00e-152	532.00
IUUC-Csa-023374	Chlorocebus sabaeus	99.61	2.00e-153	535.00
IUUC-Cho-024933	Choloepus hoffmanni	99.61	3.00e-153	533.00
IUUC-Dre-027711	Danio rerio	91.30	9.00e-141	492.00
IUUC-Dno-029260	Dasypus novemcinctus	99.59	1.00e-147	515.00
IUUC-Dor-030489	Dipodomys ordii	95.68	4.00e-107	379.00
IUUC-Ete-032946	Echinops telfairi	98.07	3.00e-154	537.00
IUUC-Eca-033546	Equus caballus	98.10	6.00e-157	546.00
IUUC-Eeu-034861	Erinaceus europaeus	94.98	6.00e-148	516.00
IUUC-Fal-037160	Ficedula albicollis	88.05	2.00e-132	464.00
IUUC-Gmo-039091	Gadus morhua	89.33	6.00e-139	486.00
IUUC-Gga-040252	Gallus gallus	97.66	3.00e-151	527.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.33	3.00e-139	487.00
IUUC-Ggo-044618	Gorilla gorilla	99.61	2.00e-153	535.00
IUUC-Hsa-046179	Homo sapiens	99.61	2.00e-153	535.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	98.05	6.00e-152	529.00
IUUC-Lch-049496	Latimeria chalumnae	94.21	6.00e-149	519.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	5.00e-141	493.00
IUUC-Laf-054257	Loxodonta africana	98.08	2.00e-153	534.00
IUUC-Mcc-055023	Macaca mulatta	99.61	2.00e-153	535.00
IUUC-Meu-055922	Macropus eugenii	96.86	6.00e-149	519.00
IUUC-Mga-060070	Meleagris gallopavo	95.04	2.00e-148	518.00
IUUC-Mmr-061494	Microcebus murinus	99.61	2.00e-153	535.00
IUUC-Mdo-061971	Monodelphis domestica	98.43	6.00e-152	529.00
IUUC-Mmu-063206	Mus musculus	99.61	1.00e-152	532.00
IUUC-Mpu-066597	Mustela putorius furo	99.61	2.00e-153	535.00
IUUC-Mlu-067199	Myotis lucifugus	99.22	7.00e-153	533.00
IUUC-Nle-069342	Nomascus leucogenys	99.61	2.00e-153	535.00
IUUC-Opr-070341	Ochotona princeps	56.86	4.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	89.72	4.00e-140	490.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	6.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	99.23	3.00e-155	540.00
IUUC-Oga-089154	Otolemur garnettii	99.61	2.00e-153	535.00
IUUC-Ptr-091088	Pan troglodytes	99.61	2.00e-153	535.00
IUUC-Psi-093079	Pelodiscus sinensis	98.08	5.00e-155	539.00
IUUC-Pfo-097007	Poecilia formosa	84.98	8.00e-133	466.00
IUUC-Pab-098092	Pongo abelii	99.61	2.00e-153	535.00
IUUC-Pca-100328	Procavia capensis	97.25	2.00e-148	518.00
IUUC-Pva-102368	Pteropus vampyrus	99.11	1.00e-63	236.00
IUUC-Rno-105477	Rattus norvegicus	99.61	1.00e-152	532.00
IUUC-Sha-107630	Sarcophilus harrisii	97.70	1.00e-154	538.00
IUUC-Ssc-116441	Sus scrofa	100.00	1.00e-153	535.00
IUUC-Tru-118004	Takifugu rubripes	86.96	1.00e-134	472.00
IUUC-Tsy-119548	Tarsius syrichta	88.72	5.00e-67	246.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.54	7.00e-137	479.00
IUUC-Vpa-130799	Vicugna pacos	100.00	2.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence