iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053993

UUCD1 version

UUC-LoA-00406

Ensembl Protein ID

ENSLAFP00000009990.3

UniProt Accession

G3T8H4; G3T8H4_LOXAF

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011955.3	ENSLAFT00000011954.3	ENSLAFP00000009990.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-43	142.7	341	376
UBD/Beta-Prp	1.10e-47	163.0	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNYVKLWDTRSCK 376
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   + + s+s+d tirvwd+etg+  + tl+g++ v ncv+++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPIVTLSGHKEAISSVLWSD-AEEVCSASWDHTIRVWDIETGSLKS-TLTGNK-VFNCVSYSPLCKRLASGSTDRHIRLWDPrsKDG 331
           67899****************9.999*********************9.***987.99*************************965666 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld++vklwd +  +  ++ l +h+d v+ v+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNYVKLWDTRsCKAPLYDLAAHEDKVLGVDWT-DSGLLLSGGADNKLYSY 412
           777654365.************9889*****************54566****************9.***********998765 PP

Organism

Loxodonta africana

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LEAKNEFHKH VEFDFLVKGQ 60
FLRMPLVKHM ELENISSEEV VELEYVEKYT APQPEQCMFH DDWISSVKGA EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCAGC TCCAGACACG CTTCTACACT GACAACAAGA AGTAAGTGAG CGTCCCCTTC 60
TCTCCTTTCC TCTCCCCTCC CTGGGATCCT TTCGGCTTGA CCTTGCGGAT CTTTGTTTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

KEGG

lav:100657511

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.49	4.00e-58	218.00
IUUC-Aml-001997	Ailuropoda melanoleuca	95.61	0.00e+00	765.00
IUUC-Atr-002544	Amborella trichopoda	33.10	1.00e-56	213.00
IUUC-Apl-003981	Anas platyrhynchos	86.97	0.00e+00	664.00
IUUC-Aca-004370	Anolis carolinensis	83.53	0.00e+00	716.00
IUUC-Aly-006455	Arabidopsis lyrata	33.74	9.00e-59	220.00
IUUC-Ath-006669	Arabidopsis thaliana	32.68	2.00e-54	206.00
IUUC-Ago-007864	Ashbya gossypii	29.93	2.00e-39	156.00
IUUC-Acl-008177	Aspergillus clavatus	29.02	8.00e-38	151.00
IUUC-Afl-008617	Aspergillus flavus	28.21	1.00e-36	147.00
IUUC-Afu-008752	Aspergillus fumigatus	27.80	8.00e-34	138.00
IUUC-Ani-009136	Aspergillus nidulans	28.79	8.00e-36	144.00
IUUC-Ang-009701	Aspergillus niger	27.95	2.00e-34	139.00
IUUC-Aor-009884	Aspergillus oryzae	28.46	3.00e-36	146.00
IUUC-Ame-011432	Astyanax mexicanus	77.54	0.00e+00	667.00
IUUC-Bgr-012218	Blumeria graminis	28.57	1.00e-33	137.00
IUUC-Bta-012829	Bos taurus	95.27	0.00e+00	792.00
IUUC-Bci-013953	Botrytis cinerea	30.31	3.00e-37	149.00
IUUC-Bdi-014351	Brachypodium distachyon	35.78	3.00e-57	215.00
IUUC-Bol-016190	Brassica oleracea	34.45	3.00e-54	206.00
IUUC-Bra-018095	Brassica rapa	33.68	2.00e-54	206.00
IUUC-Cel-018569	Caenorhabditis elegans	32.60	6.00e-49	188.00
IUUC-Cja-019468	Callithrix jacchus	94.56	0.00e+00	771.00
IUUC-Cfa-020471	Canis familiaris	94.56	0.00e+00	764.00
IUUC-Cpo-022260	Cavia porcellus	94.09	0.00e+00	769.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	29.70	9.00e-39	154.00
IUUC-Csa-023989	Chlorocebus sabaeus	94.33	0.00e+00	773.00
IUUC-Cho-024426	Choloepus hoffmanni	91.11	3.00e-163	567.00
IUUC-Cin-025789	Ciona intestinalis	44.39	5.00e-100	357.00
IUUC-Cne-027063	Cryptococcus neoformans	24.32	3.00e-21	96.30
IUUC-Dre-027907	Danio rerio	78.25	0.00e+00	677.00
IUUC-Dno-029225	Dasypus novemcinctus	94.56	0.00e+00	786.00
IUUC-Dor-031082	Dipodomys ordii	77.78	6.00e-174	603.00
IUUC-Dse-031308	Dothistroma septosporum	27.98	1.00e-37	150.00
IUUC-Dme-032189	Drosophila melanogaster	40.78	8.00e-94	337.00
IUUC-Ete-032247	Echinops telfairi	91.02	0.00e+00	745.00
IUUC-Eca-034285	Equus caballus	95.27	0.00e+00	791.00
IUUC-Eeu-035322	Erinaceus europaeus	84.17	0.00e+00	661.00
IUUC-Fca-036114	Felis catus	94.56	0.00e+00	787.00
IUUC-Fal-036891	Ficedula albicollis	86.16	3.00e-179	620.00
IUUC-Fox-037965	Fusarium oxysporum	25.37	1.00e-35	144.00
IUUC-Fso-038244	Fusarium solani	26.64	2.00e-35	143.00
IUUC-Gmo-039040	Gadus morhua	76.36	0.00e+00	681.00
IUUC-Ggr-040093	Gaeumannomyces graminis	24.09	6.00e-11	62.40
IUUC-Gga-040610	Gallus gallus	83.92	0.00e+00	729.00
IUUC-Gac-042117	Gasterosteus aculeatus	75.65	0.00e+00	652.00
IUUC-Gma-043146	Glycine max	36.45	5.00e-66	244.00
IUUC-Ggo-045179	Gorilla gorilla	93.85	0.00e+00	764.00
IUUC-Hsa-046114	Homo sapiens	94.56	0.00e+00	769.00
IUUC-Hvu-047331	Hordeum vulgare	34.10	1.00e-53	203.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	93.85	0.00e+00	783.00
IUUC-Kpa-049304	Komagataella pastoris	30.00	2.00e-43	169.00
IUUC-Lch-050655	Latimeria chalumnae	77.01	2.00e-149	521.00
IUUC-Lpe-051675	Leersia perrieri	35.08	8.00e-60	224.00
IUUC-Loc-052868	Lepisosteus oculatus	80.85	0.00e+00	683.00
IUUC-Lma-053258	Leptosphaeria maculans	25.86	2.00e-31	132.00
IUUC-Mcc-055128	Macaca mulatta	77.07	4.00e-176	610.00
IUUC-Meu-056501	Macropus eugenii	76.94	2.00e-165	574.00
IUUC-Mor-057114	Magnaporthe oryzae	26.00	9.00e-27	114.00
IUUC-Mtr-058367	Medicago truncatula	35.65	5.00e-61	228.00
IUUC-Mla-059107	Melampsora laricipopulina	27.86	2.00e-30	127.00
IUUC-Mga-059745	Meleagris gallopavo	81.18	0.00e+00	702.00
IUUC-Mvi-060362	Microbotryum violaceum	29.85	1.00e-35	144.00
IUUC-Mdo-062257	Monodelphis domestica	84.01	0.00e+00	731.00
IUUC-Mmu-063546	Mus musculus	91.73	0.00e+00	771.00
IUUC-Mac-065540	Musa acuminata	33.97	4.00e-55	208.00
IUUC-Mpu-066284	Mustela putorius furo	95.51	0.00e+00	795.00
IUUC-Mlu-067241	Myotis lucifugus	94.09	0.00e+00	786.00
IUUC-Nfi-068260	Neosartorya fischeri	27.56	1.00e-35	144.00
IUUC-Ncr-068719	Neurospora crassa	26.73	7.00e-27	115.00
IUUC-Nle-068981	Nomascus leucogenys	94.33	0.00e+00	748.00
IUUC-Opr-071218	Ochotona princeps	86.68	0.00e+00	687.00
IUUC-Ont-071646	Oreochromis niloticus	77.59	0.00e+00	683.00
IUUC-Oan-073453	Ornithorhynchus anatinus	87.71	0.00e+00	765.00
IUUC-Ocu-074008	Oryctolagus cuniculus	95.51	0.00e+00	794.00
IUUC-Oba-075712	Oryza barthii	30.77	5.00e-43	168.00
IUUC-Obr-076721	Oryza brachyantha	34.83	9.00e-60	224.00
IUUC-Ogl-077229	Oryza glaberrima	34.84	6.00e-59	221.00
IUUC-Ogu-078977	Oryza glumaepatula	30.77	3.00e-43	169.00
IUUC-Oin-079683	Oryza indica	34.84	3.00e-59	222.00
IUUC-Olo-080291	Oryza longistaminata	31.31	2.00e-30	126.00
IUUC-Ome-081834	Oryza meridionalis	35.08	4.00e-60	225.00
IUUC-Oni-082507	Oryza nivara	33.73	3.00e-55	209.00
IUUC-Opu-083396	Oryza punctata	35.08	6.00e-60	224.00
IUUC-Oru-085220	Oryza rufipogon	34.29	8.00e-55	207.00
IUUC-Osa-085767	Oryza sativa	34.84	3.00e-59	222.00
IUUC-Ola-087420	Oryzias latipes	77.30	0.00e+00	679.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.78	3.00e-39	155.00
IUUC-Oga-088264	Otolemur garnettii	94.56	0.00e+00	769.00
IUUC-Oar-089335	Ovis aries	95.27	0.00e+00	791.00
IUUC-Ptr-091320	Pan troglodytes	94.56	0.00e+00	769.00
IUUC-Pan-092833	Papio anubis	93.85	0.00e+00	768.00
IUUC-Psi-093504	Pelodiscus sinensis	86.29	0.00e+00	731.00
IUUC-Pma-094189	Petromyzon marinus	68.87	4.00e-175	607.00
IUUC-Pno-094929	Phaeosphaeria nodorum	24.89	8.00e-33	134.00
IUUC-Ppa-095429	Physcomitrella patens	34.20	3.00e-65	242.00
IUUC-Pfo-096337	Poecilia formosa	75.41	0.00e+00	682.00
IUUC-Pab-097571	Pongo abelii	94.09	0.00e+00	768.00
IUUC-Pop-099977	Populus trichocarpa	34.86	3.00e-64	239.00
IUUC-Pca-100394	Procavia capensis	92.91	0.00e+00	710.00
IUUC-Ppe-101848	Prunus persica	34.52	2.00e-60	226.00
IUUC-Pva-102921	Pteropus vampyrus	96.76	1.00e-122	432.00
IUUC-Pgr-103637	Puccinia graminis	28.82	1.00e-35	144.00
IUUC-Ptt-103781	Puccinia triticina	28.82	3.00e-35	142.00
IUUC-Pte-104135	Pyrenophora teres	26.72	1.00e-32	135.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.49	7.00e-32	131.00
IUUC-Rno-105114	Rattus norvegicus	92.43	0.00e+00	772.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.89	8.00e-41	161.00
IUUC-Sha-107122	Sarcophilus harrisii	84.91	0.00e+00	704.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	31.78	6.00e-50	191.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.33	1.00e-40	160.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.90	2.00e-38	153.00
IUUC-Smo-108720	Selaginella moellendorffii	33.33	8.00e-59	220.00
IUUC-Sit-110311	Setaria italica	36.06	2.00e-57	216.00
IUUC-Sly-111023	Solanum lycopersicum	31.64	2.00e-54	206.00
IUUC-Stu-112778	Solanum tuberosum	34.61	1.00e-60	226.00
IUUC-Sar-113596	Sorex araneus	76.36	9.00e-174	602.00
IUUC-Sbi-114193	Sorghum bicolor	35.11	1.00e-58	220.00
IUUC-Sre-115002	Sporisorium reilianum	24.14	7.00e-12	65.10
IUUC-Ssc-116066	Sus scrofa	94.80	0.00e+00	787.00
IUUC-Tgu-117048	Taeniopygia guttata	84.84	0.00e+00	655.00
IUUC-Tsy-119573	Tarsius syrichta	61.24	5.00e-136	477.00
IUUC-Tni-119820	Tetraodon nigroviridis	76.01	0.00e+00	681.00
IUUC-Tca-121605	Theobroma cacao	35.58	4.00e-63	235.00
IUUC-Tre-121947	Trichoderma reesei	26.28	6.00e-35	141.00
IUUC-Tvi-122481	Trichoderma virens	26.28	3.00e-36	146.00
IUUC-Tae-125861	Triticum aestivum	33.73	4.00e-58	218.00
IUUC-Tur-126586	Triticum urartu	34.36	9.00e-56	210.00
IUUC-Tme-126900	Tuber melanosporum	32.39	8.00e-50	191.00
IUUC-Tbe-127736	Tupaia belangeri	71.86	8.00e-152	529.00
IUUC-Ttr-129041	Tursiops truncatus	83.22	0.00e+00	676.00
IUUC-Vpa-130260	Vicugna pacos	95.27	0.00e+00	793.00
IUUC-Vvi-131009	Vitis vinifera	35.00	8.00e-62	230.00
IUUC-Xtr-132083	Xenopus tropicalis	80.38	0.00e+00	691.00
IUUC-Xma-133094	Xiphophorus maculatus	74.94	0.00e+00	677.00
IUUC-Yli-134531	Yarrowia lipolytica	23.82	3.00e-21	96.70
IUUC-Zma-135509	Zea mays	33.65	8.00e-59	221.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence