iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000011164.4	ENSCAFT00000045142.2	ENSCAFP00000038038.1
ENSCAFG00000011164.4	ENSCAFT00000017793.2	ENSCAFP00000016471.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.60e-200	665.4	411	886

Active Site

Position(s)	Description	Evidence
595	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+ +++llvGag++GcEllK+++l+G+     g +tv Dmd+ve snl+rqFLf  +d+g+ KAevaaea ++l
   Q: 411  YDGQIAVFGAGFQEKLSWQHYLLVGAGAIGCELLKSFALVGLgagpsGGVTVADMDHVEHSNLSRQFLFTTQDIGRLKAEVAAEATHRL 499
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+d +v++ +  +++++e+i+   Ff+++d+V++ald+++ar++v+ +c+++ +pl+e+gt G++G+++v+++++te+y++++    ++
   Q: 500  NSDLQVTPLTMLLDPTTEHIFgdnFFSRVDGVAAALDSFQARKYVAARCTHYLKPLLEAGTQGTMGHASVFMPHVTEAYRAPTstlASE 588
           ***************************************************************************************** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           ++t+P+ctl+ +p+ +eht++wa         l +++++++++  + l+++d  + ++ +++v  ++  e+++++++++ +a+ +++ +
   Q: 589  ETTYPVCTLRYFPSRVEHTVQWArnkfeglfCLSAETINHNQQVLTSLAETDGPQVLTLLQEV-LGILRERPQTWQDCVLWALGHWQLC 676
           ***************************************************************.6667778****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           + +si qll++f++d+v ++++ fw+                                                ++ ++   +   ++ 
   Q: 677  FCYSIMQLLNHFPPDKVLEDGTLFWSgpkqcpqplefdanqdthllyvlaaanlyaqmhglpgsrdqtalrgllKLLPLPVPQHLAPNS 765
           ***********************************888888888888888888888888888888888888888666665555544555 PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
             d +   asa+     l+ l ++le ++  + +kp  l+fekd ds  ++d+v+aaa+lra+++gi p +++++ k+i+g+iipaiat
   Q: 766  PNDLKLAPASAEygpeqLKKLQEVLEVWSGSPPLKP--LKFEKDNDSnfHMDFVAAAASLRAQNYGILP-ANRSQSKRIVGKIIPAIAT 851
           445444444444588889999999999999999999..9*******99*********************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv    + ++++++fl++ae
   Q: 852  TTAAVAGLVGLELYKVVGRprPLSAFRHCFLHLAE 886
           ******************9888999****999876 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MDVLETSKLV DEELYSRQLY VLDMPAMQRI REAKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLAAQFFLSE QDLETSRAEA SRELVAKLNK GVQVSVHTGD ITEELLLGFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGTCC TGGAGACCTC CAAGTTGGTG GATGAGGAGC TATATTCACG GCAACTGTGA 60
GGCCCAAGGT GGGGAAGGGG GGTGGGGTGG CCTTCTGACT TCCAATCTCC TGTCTACCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

KEGG

cfa:608118

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	84.44	0.00e+00	1599.00
IUUC-Bta-012665	Bos taurus	76.09	0.00e+00	1367.00
IUUC-Cja-019047	Callithrix jacchus	78.36	0.00e+00	1507.00
IUUC-Cpo-022336	Cavia porcellus	69.92	0.00e+00	1317.00
IUUC-Csa-023462	Chlorocebus sabaeus	81.32	0.00e+00	1499.00
IUUC-Cho-024436	Choloepus hoffmanni	80.17	2.00e-104	373.00
IUUC-Dno-029347	Dasypus novemcinctus	78.46	0.00e+00	1471.00
IUUC-Dor-030997	Dipodomys ordii	73.91	0.00e+00	1372.00
IUUC-Ete-033124	Echinops telfairi	73.96	0.00e+00	960.00
IUUC-Eca-033929	Equus caballus	83.20	0.00e+00	1654.00
IUUC-Eeu-034717	Erinaceus europaeus	70.57	0.00e+00	1011.00
IUUC-Fca-036564	Felis catus	85.80	0.00e+00	1620.00
IUUC-Ggo-044480	Gorilla gorilla	81.04	0.00e+00	1497.00
IUUC-Hsa-046498	Homo sapiens	80.34	0.00e+00	1484.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	76.76	0.00e+00	1440.00
IUUC-Laf-054119	Loxodonta africana	77.48	0.00e+00	1504.00
IUUC-Mcc-055597	Macaca mulatta	78.84	0.00e+00	1428.00
IUUC-Mdo-063058	Monodelphis domestica	58.03	0.00e+00	1028.00
IUUC-Mmu-063578	Mus musculus	71.57	0.00e+00	1394.00
IUUC-Mpu-066255	Mustela putorius furo	84.32	0.00e+00	1616.00
IUUC-Mlu-067814	Myotis lucifugus	74.93	0.00e+00	1349.00
IUUC-Nle-069193	Nomascus leucogenys	81.25	0.00e+00	1510.00
IUUC-Opr-070715	Ochotona princeps	70.85	0.00e+00	1335.00
IUUC-Ocu-074162	Oryctolagus cuniculus	76.96	0.00e+00	1425.00
IUUC-Oga-088895	Otolemur garnettii	75.77	0.00e+00	1390.00
IUUC-Oar-089579	Ovis aries	75.69	0.00e+00	1368.00
IUUC-Ptr-090581	Pan troglodytes	80.56	0.00e+00	1459.00
IUUC-Pan-092458	Papio anubis	81.32	0.00e+00	1491.00
IUUC-Pab-098653	Pongo abelii	75.89	0.00e+00	1410.00
IUUC-Pca-100578	Procavia capensis	72.26	0.00e+00	850.00
IUUC-Pva-102914	Pteropus vampyrus	80.02	0.00e+00	1217.00
IUUC-Rno-106066	Rattus norvegicus	72.90	0.00e+00	1433.00
IUUC-Sha-107368	Sarcophilus harrisii	60.18	0.00e+00	1113.00
IUUC-Ssc-115743	Sus scrofa	80.04	0.00e+00	1522.00
IUUC-Tbe-127587	Tupaia belangeri	72.33	0.00e+00	1216.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence