iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067814

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02053952

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000011521.2	ENSMLUT00000011545.2	ENSMLUP00000010519.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.50e-188	624.9	419	890

Active Site

Position(s)	Description	Evidence
603	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qe+l+ +++llvGag++GcEllK ++l+G+     g +tv Dmd+ve snl+rqFLfra+dvg++KAe+aaea ++l
   Q: 419  YDGQIAVFGAGFQEQLSHQHYLLVGAGAIGCELLKGFALVGLgagagGGVTVADMDHVERSNLSRQFLFRAQDVGRPKAEAAAEATRRL 507
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v++ +  +++++e+ +   Ff ++d+V++ald+++arr+v+ +c ++ +pl+e+gt G+ G ++v+++++te y+++     p 
   Q: 508  NPDLQVTPLTHALDPTTERLYgdsFFPRVDGVAAALDSFQARRYVAARCAHYLKPLLEAGTQGTRGSASVFVPHVTEGYRAPAsaaAPG 596
           *************************************************************************************9*** PP
   S: 168  qktiPfctlketpnaaehtiewa.........vlfnklleeeageee..vlekldseekeegkdkvkselksedeenfeeaieiavkaf 245
           +  +P+ct++++p++a ht++wa           ++ ++++++g++    +   ++  ++ g +  + +  ++ ++++++++ +a+ ++
   Q: 597  DAPYPVCTVRHFPSTAGHTVQWAreefqwlfcLSAETINSHQPGASApgLSGSPQKPPFSPGPRWQTGGCPETSSRSWQDCVVWALGHW 685
           ************************999999863333334444444331133333445556667777778888***************** PP
   S: 246  akttinsikqllksfecdivtkskspfwv................................................sfcsnaealqvp 286
           + ++ ++i  ll+  ++d+v k+++pfw+                                                ++ +  + +   
   Q: 686  QLCFGYGIARLLRRHPPDKVLKDGTPFWSgprqcpqplqfdasqdthllyvlaaanlyaqmhglpgsrdpsalremlELLPRPDPQCLE 774
           *********************************99999999999998888888888888888888887777666666444444444433 PP
   S: 287  ekvekdeevvkasap.lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiatt 372
           +   +d +  + + +    l +al+ +++ + ++p  l+fekd ds  +vd+vtaaa+lra+++gi++ +++ + k+i+g+iipaiatt
   Q: 775  PILSSDLASPELDPQqEARLQEALQDWSEGSPLEP--LRFEKDNDSnfHVDFVTAAASLRAQNYGIPA-ATRAQSKRIVGQIIPAIATT 860
           33333333332222234457789999***999999..*******************************.******************** PP
   S: 373  navvgGlaaqEviKvvsg..kfeplknffl 400
           +a+v+Gl+ +E++Kvv g  + +++++ +l
   Q: 861  TAAVAGLLGLELFKVVGGprPRSAFRHSYL 890
           ****************99666666776665 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MDVPDASKLL DEELYSRQLY VLGLPAMQRL QEGKVLLSGL QGLGAEVAKN LVLMGVGSLT 60
LHDPQPTCWA DLAAQFFLSE RDLARGRAEA SQERVAKLNG AVQVCVHTGD ITEDLLRDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATGTCC CCGACGCCTC CAAGCTGCTG GATGAGGAGC TGTACTCCCG GCAGCTGTGA 60
GGCCCGAGGT GGGGAGGGAG GGGTGGCCTC TGACCTCTGA GCTCCAGTTC ACTGCCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	75.74	0.00e+00	1396.00
IUUC-Bta-012665	Bos taurus	73.87	0.00e+00	1305.00
IUUC-Cja-019047	Callithrix jacchus	73.87	0.00e+00	1350.00
IUUC-Cfa-021225	Canis familiaris	74.93	0.00e+00	1403.00
IUUC-Cpo-022336	Cavia porcellus	65.92	0.00e+00	1224.00
IUUC-Csa-023462	Chlorocebus sabaeus	76.51	0.00e+00	1358.00
IUUC-Cho-024436	Choloepus hoffmanni	73.86	2.00e-91	330.00
IUUC-Dno-029347	Dasypus novemcinctus	76.30	0.00e+00	1372.00
IUUC-Dor-030997	Dipodomys ordii	68.88	0.00e+00	1268.00
IUUC-Ete-033124	Echinops telfairi	68.49	0.00e+00	871.00
IUUC-Eca-033929	Equus caballus	75.81	0.00e+00	1453.00
IUUC-Eeu-034717	Erinaceus europaeus	67.03	0.00e+00	930.00
IUUC-Fca-036564	Felis catus	76.93	0.00e+00	1420.00
IUUC-Ggo-044480	Gorilla gorilla	76.65	0.00e+00	1367.00
IUUC-Hsa-046498	Homo sapiens	76.12	0.00e+00	1345.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	71.41	0.00e+00	1311.00
IUUC-Laf-054119	Loxodonta africana	71.99	0.00e+00	1346.00
IUUC-Mcc-055597	Macaca mulatta	75.10	0.00e+00	1303.00
IUUC-Meu-056534	Macropus eugenii	46.97	0.00e+00	815.00
IUUC-Mdo-063058	Monodelphis domestica	54.84	0.00e+00	964.00
IUUC-Mmu-063578	Mus musculus	67.76	0.00e+00	1271.00
IUUC-Mpu-066255	Mustela putorius furo	75.37	0.00e+00	1414.00
IUUC-Nle-069193	Nomascus leucogenys	75.83	0.00e+00	1352.00
IUUC-Opr-070715	Ochotona princeps	65.75	0.00e+00	1204.00
IUUC-Ocu-074162	Oryctolagus cuniculus	71.07	0.00e+00	1294.00
IUUC-Oga-088895	Otolemur garnettii	71.60	0.00e+00	1308.00
IUUC-Oar-089579	Ovis aries	73.18	0.00e+00	1290.00
IUUC-Ptr-090581	Pan troglodytes	76.17	0.00e+00	1314.00
IUUC-Pan-092458	Papio anubis	76.61	0.00e+00	1353.00
IUUC-Pab-098653	Pongo abelii	71.15	0.00e+00	1278.00
IUUC-Pca-100578	Procavia capensis	67.44	0.00e+00	767.00
IUUC-Pva-102914	Pteropus vampyrus	75.45	0.00e+00	1139.00
IUUC-Rno-106066	Rattus norvegicus	68.51	0.00e+00	1301.00
IUUC-Sha-107368	Sarcophilus harrisii	57.93	0.00e+00	1045.00
IUUC-Ssc-115743	Sus scrofa	75.02	0.00e+00	1395.00
IUUC-Tbe-127587	Tupaia belangeri	75.86	0.00e+00	1024.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence