iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088909

Ensembl Protein ID

ENSOGAP00000013138.2

UniProt Accession

H0XBP2; H0XBP2_OTOGA

Genbank Protein ID

ENSOGAP00000013138

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03092239

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000014655.2	ENSOGAT00000014668.2	ENSOGAP00000013138.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	5.70e-12	46.0	155	213

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL 62
           +e+rl+++t ++r+r+lLd+++v+ ++l++fll+  + l+++ a + ++++++ + L+ L
   Q: 155  DEIRLPIFTSSQRARRLLDLATVKTNGLAAFLLQCIQDLPVPRALPFEAAACK-KYLSKL 213
           8***************************************************9.777666 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

RSSVLTLLSS PGCEMCSQEA LQAQRSQLVG LLVSGSLEGF ESILDCLLSW EVLSWEEYEG 60
LCVLGQPLSH SARRLLDTVW SKGAWGCEKL IAAVREGQAS TQSLELHDCW DPHSLHPAQD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGTTCTG TACTGACCTT GCTTTCCTCC CCAGGTTGTG AGATGTGCTC ACAGGAGGCT 60
TTGCAGGCAC AGAGAAGCCA GCTTGTGGGG CTGCTGGTCT CGGGATCCCT GGAAGGCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	80.39	0.00e+00	1444.00
IUUC-Ame-011021	Astyanax mexicanus	46.45	0.00e+00	890.00
IUUC-Bta-013241	Bos taurus	80.26	0.00e+00	1587.00
IUUC-Cja-019633	Callithrix jacchus	80.84	0.00e+00	1223.00
IUUC-Cfa-020039	Canis familiaris	80.85	0.00e+00	1568.00
IUUC-Cpo-022337	Cavia porcellus	77.66	0.00e+00	1471.00
IUUC-Csa-023906	Chlorocebus sabaeus	83.96	0.00e+00	1642.00
IUUC-Dre-027568	Danio rerio	47.20	0.00e+00	838.00
IUUC-Dno-029098	Dasypus novemcinctus	80.33	0.00e+00	1457.00
IUUC-Dor-031102	Dipodomys ordii	73.65	0.00e+00	686.00
IUUC-Ete-032943	Echinops telfairi	75.36	0.00e+00	1079.00
IUUC-Eca-034310	Equus caballus	82.84	0.00e+00	1588.00
IUUC-Eeu-034589	Erinaceus europaeus	80.48	8.00e-157	548.00
IUUC-Fca-036252	Felis catus	81.18	0.00e+00	806.00
IUUC-Gac-041442	Gasterosteus aculeatus	45.97	0.00e+00	813.00
IUUC-Ggo-044861	Gorilla gorilla	84.23	0.00e+00	1598.00
IUUC-Hsa-046093	Homo sapiens	84.23	0.00e+00	1602.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	80.46	0.00e+00	1452.00
IUUC-Lch-049454	Latimeria chalumnae	52.95	0.00e+00	912.00
IUUC-Laf-053553	Loxodonta africana	82.35	0.00e+00	1473.00
IUUC-Mcc-055772	Macaca mulatta	84.18	0.00e+00	1618.00
IUUC-Meu-056785	Macropus eugenii	68.09	2.00e-113	403.00
IUUC-Mmr-060596	Microcebus murinus	85.20	0.00e+00	1621.00
IUUC-Mdo-062983	Monodelphis domestica	66.98	0.00e+00	1101.00
IUUC-Mmu-063951	Mus musculus	75.07	0.00e+00	1469.00
IUUC-Mpu-066412	Mustela putorius furo	80.26	0.00e+00	1555.00
IUUC-Mlu-067601	Myotis lucifugus	79.55	0.00e+00	1410.00
IUUC-Nle-069913	Nomascus leucogenys	84.59	0.00e+00	1341.00
IUUC-Opr-070999	Ochotona princeps	81.62	0.00e+00	951.00
IUUC-Ont-072512	Oreochromis niloticus	46.36	0.00e+00	882.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.43	0.00e+00	1088.00
IUUC-Ocu-074837	Oryctolagus cuniculus	84.09	0.00e+00	1585.00
IUUC-Ola-086555	Oryzias latipes	45.74	0.00e+00	816.00
IUUC-Oar-089315	Ovis aries	79.49	0.00e+00	1518.00
IUUC-Ptr-090542	Pan troglodytes	84.13	0.00e+00	1597.00
IUUC-Pan-092545	Papio anubis	84.06	0.00e+00	1611.00
IUUC-Pma-094167	Petromyzon marinus	33.49	1.00e-62	234.00
IUUC-Ppa-095344	Physcomitrella patens	25.56	4.00e-07	50.40
IUUC-Pfo-096976	Poecilia formosa	44.60	0.00e+00	838.00
IUUC-Pab-098481	Pongo abelii	83.74	0.00e+00	1581.00
IUUC-Pca-100135	Procavia capensis	74.01	0.00e+00	1258.00
IUUC-Pva-102127	Pteropus vampyrus	79.16	0.00e+00	1401.00
IUUC-Rno-105783	Rattus norvegicus	77.07	0.00e+00	1463.00
IUUC-Sce-106163	Saccharomyces cerevisiae	26.88	9.90e-02	33.10
IUUC-Sar-113448	Sorex araneus	75.43	0.00e+00	919.00
IUUC-Tru-118708	Takifugu rubripes	44.50	0.00e+00	773.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.42	9.00e-33	134.00
IUUC-Tbe-127661	Tupaia belangeri	83.55	0.00e+00	819.00
IUUC-Ttr-128318	Tursiops truncatus	75.37	0.00e+00	1366.00
IUUC-Vpa-130502	Vicugna pacos	73.16	1.00e-154	540.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence