iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004291

UUCD1 version

UUC-AnC-00396

Ensembl Protein ID

ENSACAP00000003745.3

UniProt Accession

H9G853; H9G853_ANOCA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000003738.3	ENSACAT00000003836.3	ENSACAP00000003745.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-135	449.5	525	857

Active Site

Position(s)	Description	Evidence
826	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 525  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 612
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ +ilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 613  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELFFIQDMDILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 698
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 699  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 786
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s e+lkekLl+Aieet+gF++
   Q: 787  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQ 857
           *********************************************************************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MASAGLSGEK SPLTVKVVSA KPKGPGRRQP RITSFVEVAA DGLPSETKRT AKKAGGAELL 60
WNESLVLNVT PQTQLEVKLW SCHTLRNELL GAASVGLPGL LRQSKGRVEN KQLILNLQME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACCAAAATA TCACGATGTA TTGAAAACAT TGACTACAAA AATGCGTTGG ATAATCCAGA 60
ACGTTGGATA AGCGAGTGTT GGATAAGTGA GACTCTACTG TATAGAGAGA GAGATTTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	78.60	0.00e+00	1399.00
IUUC-Apl-003912	Anas platyrhynchos	73.91	0.00e+00	1200.00
IUUC-Bta-013231	Bos taurus	79.17	0.00e+00	1389.00
IUUC-Cja-019455	Callithrix jacchus	79.70	0.00e+00	1414.00
IUUC-Cfa-021017	Canis familiaris	79.93	0.00e+00	1394.00
IUUC-Cpo-021988	Cavia porcellus	79.93	0.00e+00	1396.00
IUUC-Csa-023549	Chlorocebus sabaeus	79.93	0.00e+00	1424.00
IUUC-Dre-028513	Danio rerio	72.61	0.00e+00	1282.00
IUUC-Dno-028976	Dasypus novemcinctus	79.75	0.00e+00	1410.00
IUUC-Dor-030176	Dipodomys ordii	80.14	0.00e+00	1346.00
IUUC-Eca-033949	Equus caballus	80.16	0.00e+00	1407.00
IUUC-Eeu-034529	Erinaceus europaeus	72.73	0.00e+00	1132.00
IUUC-Fca-036236	Felis catus	80.16	0.00e+00	1414.00
IUUC-Fal-036948	Ficedula albicollis	76.42	0.00e+00	1300.00
IUUC-Gmo-038842	Gadus morhua	89.42	0.00e+00	1075.00
IUUC-Gga-040617	Gallus gallus	76.52	0.00e+00	1368.00
IUUC-Gac-041338	Gasterosteus aculeatus	88.87	0.00e+00	1087.00
IUUC-Ggo-045278	Gorilla gorilla	80.39	0.00e+00	1430.00
IUUC-Hsa-046148	Homo sapiens	80.39	0.00e+00	1432.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	96.27	0.00e+00	1097.00
IUUC-Lch-050663	Latimeria chalumnae	74.89	0.00e+00	1345.00
IUUC-Loc-052604	Lepisosteus oculatus	74.43	0.00e+00	1297.00
IUUC-Laf-053944	Loxodonta africana	79.48	0.00e+00	1408.00
IUUC-Mcc-055655	Macaca mulatta	79.93	0.00e+00	1424.00
IUUC-Meu-055953	Macropus eugenii	71.35	0.00e+00	1228.00
IUUC-Mga-060190	Meleagris gallopavo	77.15	0.00e+00	1376.00
IUUC-Mmr-060896	Microcebus murinus	80.65	0.00e+00	1407.00
IUUC-Mdo-062536	Monodelphis domestica	81.40	0.00e+00	1441.00
IUUC-Mmu-064017	Mus musculus	80.90	0.00e+00	1404.00
IUUC-Mpu-066608	Mustela putorius furo	78.21	0.00e+00	1352.00
IUUC-Mlu-067623	Myotis lucifugus	77.12	0.00e+00	1340.00
IUUC-Nle-069496	Nomascus leucogenys	78.02	0.00e+00	1377.00
IUUC-Opr-071054	Ochotona princeps	73.81	0.00e+00	1263.00
IUUC-Ont-071279	Oreochromis niloticus	71.26	0.00e+00	1252.00
IUUC-Oan-073512	Ornithorhynchus anatinus	78.30	0.00e+00	1358.00
IUUC-Ocu-074271	Oryctolagus cuniculus	80.58	0.00e+00	1397.00
IUUC-Ola-087237	Oryzias latipes	68.56	0.00e+00	1206.00
IUUC-Oga-088164	Otolemur garnettii	80.67	0.00e+00	1409.00
IUUC-Oar-089698	Ovis aries	79.40	0.00e+00	1389.00
IUUC-Ptr-091306	Pan troglodytes	79.25	0.00e+00	1400.00
IUUC-Pan-092814	Papio anubis	77.27	0.00e+00	1348.00
IUUC-Pfo-096709	Poecilia formosa	90.38	0.00e+00	1087.00
IUUC-Pab-098494	Pongo abelii	77.89	0.00e+00	1373.00
IUUC-Pca-100596	Procavia capensis	70.30	0.00e+00	1167.00
IUUC-Pva-103154	Pteropus vampyrus	77.43	0.00e+00	1302.00
IUUC-Rno-104954	Rattus norvegicus	82.70	0.00e+00	1259.00
IUUC-Sha-106781	Sarcophilus harrisii	81.75	0.00e+00	1443.00
IUUC-Ssc-116307	Sus scrofa	72.01	0.00e+00	1243.00
IUUC-Tgu-116530	Taeniopygia guttata	72.68	0.00e+00	1147.00
IUUC-Tru-118287	Takifugu rubripes	90.69	0.00e+00	1080.00
IUUC-Tsy-119097	Tarsius syrichta	66.75	0.00e+00	976.00
IUUC-Tni-120801	Tetraodon nigroviridis	69.57	0.00e+00	1206.00
IUUC-Tbe-127793	Tupaia belangeri	70.62	0.00e+00	1174.00
IUUC-Ttr-128275	Tursiops truncatus	77.91	0.00e+00	1353.00
IUUC-Xtr-132866	Xenopus tropicalis	84.92	0.00e+00	1138.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence