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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047020
UUCD1 version UUC-HoS-01087
Ensembl Protein ID ENSP00000343526.4
UniProt Accession O94782; A0PJ95; D3DQ57; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3; UBP1_HUMAN
Genbank Protein ID BAA34703.1; AAD11441.1; CAB55999.1; CAB55967.1; BAD92130.1; EAX06585.1; EAX06586.1; AAH50525.1; AAH18745.1; AAH32364.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1
Genbank Nucleotide ID AB014458; AF117386; AL117575; AL117503; AB208893; CH471059; CH471059; BC050525; BC018745; BC032364
Gene Name USP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162607.12 ENST00000339950.4 ENSP00000343526.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 21389083
Classification
Family E-value Score Start End
DUB/USP 3.50e-87 294.4 81 784
Active Site
Position(s) Description Evidence
90 Nucleophile {ECO:0000269|PubMed:15694335,
ECO:0000269|PubMed:16531995,
ECO:0000269|PubMed:26388029}
593 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w.....ksk 64
           +Gl+NlgNtCY+NS+LQ+L+++p +++ +++      +kke+l++e+++++kg          el++slq+l+ ++       +     +++
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHlfniisRKKEALKDEANQKDKGnckedslasyELICSLQSLIISVeqlqasfLlnpekYTD 172
           6************************************999999999999999999999*****99999999999995555555144555888 PP
   S: 65   kkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.......... 129
           + a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++                  e  +pkee+++ +++e++++          
   Q: 173  ELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLlkkeevknvaelptkveEIPHPKEEMNGINSIEMDSMrhsedfkekl 264
           88*****************************************556677888999999998888899999999999999998********** PP
   S: 130  ............................................................................................ 129
                                                                                                       
   Q: 265  pkgngkrksdtefgnmkkkvklskehqsleenqrqtrskrkatsdtlesppkiipkyisenesprpsqkksrvkinwlksatkqpsilskfc 356
           ******************************************************************************************** PP
   S: 130  ....................................................aeekkkkknk.....slisdlFqgqlksqikclecdnvss 164
                                                               +e k+ +k++     +l+++lFqgql  +++clec++ ++
   Q: 357  slgkittnqgvkgqskenecdpeedlgkcesdnttngcglespgntvtpvnvNEVKPINKGEeqigfELVEKLFQGQLVLRTRCLECESLTE 448
           **************************************************99555555555556666************************* PP
   S: 165  reepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf..... 237
           r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l ++k+Pev+++hLk+f     
   Q: 449  RREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFaasgl 540
           ****************99998*********************************************************************** PP
   S: 238  sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn........................... 301
           +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk                            
   Q: 541  EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdlnsleldkgnfvvdqmceigkpepl 627
           ******************************99.....678**************************************************** PP
   S: 302  ............................................................................................ 301
                                                                                                       
   Q: 628  neeeargvvenyndeevsirvggntqpskvlnkknveaigllggqkskadyelynkasnpdkvastafaenrnsetsdttgthesdrnkess 719
           ********************************************************************************999999999999 PP
   S: 302  .......................ekgkWllfdDskVtevkeeevleetg......staYvlfYkr 337
                                   +gkWllfdDs+V++++e+++l++ +      st+Y+lfYk+
   Q: 720  dqtginisgfenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLFYKK 784
           999999999988888888877766999*******************888**************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
 Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Protein Sequence
(Fasta)
MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV 60
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047020|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAGGCGGG GCTTACCGCG AGGGCCTCGC TCCGGAAGCC GCACCCTCCG CGGCGTCCCA 60
CCGTCGAGGA TTAACAAAAC GCCAAACAAG ATTTTAACAG TCGGCAGCGA AAGCGCGCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047020|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0036297--P:interstrand cross-link repair
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:7398
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001939 Ailuropoda melanoleuca 94.40 0.00e+00 1432.00
IUUC-Apl-004204 Anas platyrhynchos 73.01 0.00e+00 939.00
IUUC-Aca-004637 Anolis carolinensis 66.46 0.00e+00 935.00
IUUC-Ame-011718 Astyanax mexicanus 48.08 5.00e-173 601.00
IUUC-Bta-012552 Bos taurus 91.85 0.00e+00 1403.00
IUUC-Cja-019588 Callithrix jacchus 96.94 0.00e+00 1514.00
IUUC-Cfa-020211 Canis familiaris 94.39 0.00e+00 1440.00
IUUC-Cpo-021551 Cavia porcellus 84.08 0.00e+00 1265.00
IUUC-Csa-024186 Chlorocebus sabaeus 97.45 0.00e+00 1527.00
IUUC-Cho-024739 Choloepus hoffmanni 82.97 0.00e+00 749.00
IUUC-Dre-028184 Danio rerio 49.27 2.00e-176 612.00
IUUC-Dno-029669 Dasypus novemcinctus 90.36 0.00e+00 1395.00
IUUC-Dor-030168 Dipodomys ordii 86.93 0.00e+00 1260.00
IUUC-Dme-031732 Drosophila melanogaster 28.77 5.00e-18 87.00
IUUC-Ete-032825 Echinops telfairi 86.46 0.00e+00 952.00
IUUC-Eca-033595 Equus caballus 93.68 0.00e+00 1352.00
IUUC-Eeu-034877 Erinaceus europaeus 79.94 1.00e-160 560.00
IUUC-Fca-035381 Felis catus 93.72 0.00e+00 1011.00
IUUC-Fal-037592 Ficedula albicollis 69.38 0.00e+00 965.00
IUUC-Gmo-039680 Gadus morhua 44.32 5.00e-152 531.00
IUUC-Gga-041196 Gallus gallus 72.12 0.00e+00 1058.00
IUUC-Gac-042292 Gasterosteus aculeatus 57.25 1.00e-82 301.00
IUUC-Ggo-044671 Gorilla gorilla 99.24 0.00e+00 1560.00
IUUC-Itr-048800 Ictidomys tridecemlineatus 85.11 0.00e+00 1265.00
IUUC-Lch-050543 Latimeria chalumnae 57.22 0.00e+00 705.00
IUUC-Loc-052338 Lepisosteus oculatus 53.25 0.00e+00 704.00
IUUC-Laf-053707 Loxodonta africana 90.75 0.00e+00 1412.00
IUUC-Mcc-055885 Macaca mulatta 97.45 0.00e+00 1528.00
IUUC-Meu-056573 Macropus eugenii 67.34 0.00e+00 952.00
IUUC-Mga-059346 Meleagris gallopavo 72.73 0.00e+00 1006.00
IUUC-Mmr-061612 Microcebus murinus 93.50 0.00e+00 1404.00
IUUC-Mdo-062887 Monodelphis domestica 73.85 0.00e+00 1058.00
IUUC-Mmu-064044 Mus musculus 88.42 0.00e+00 1367.00
IUUC-Mpu-066847 Mustela putorius furo 94.78 0.00e+00 1444.00
IUUC-Mlu-067684 Myotis lucifugus 91.49 0.00e+00 1423.00
IUUC-Nle-070057 Nomascus leucogenys 98.34 0.00e+00 1548.00
IUUC-Opr-070463 Ochotona princeps 84.06 0.00e+00 1256.00
IUUC-Ont-071975 Oreochromis niloticus 51.50 5.00e-143 501.00
IUUC-Oan-073062 Ornithorhynchus anatinus 85.71 1.00e-46 178.00
IUUC-Ocu-074840 Oryctolagus cuniculus 93.12 0.00e+00 1432.00
IUUC-Ola-087088 Oryzias latipes 46.75 4.00e-173 601.00
IUUC-Oga-088472 Otolemur garnettii 92.99 0.00e+00 1428.00
IUUC-Oar-089498 Ovis aries 92.10 0.00e+00 1409.00
IUUC-Ptr-091395 Pan troglodytes 99.62 0.00e+00 1566.00
IUUC-Pan-092462 Papio anubis 97.58 0.00e+00 1528.00
IUUC-Psi-093583 Pelodiscus sinensis 71.94 0.00e+00 911.00
IUUC-Pma-094644 Petromyzon marinus 36.78 1.00e-28 119.00
IUUC-Pfo-096314 Poecilia formosa 46.69 5.00e-169 588.00
IUUC-Pab-098568 Pongo abelii 98.98 0.00e+00 1556.00
IUUC-Pca-100948 Procavia capensis 81.58 0.00e+00 1239.00
IUUC-Pva-102853 Pteropus vampyrus 93.37 0.00e+00 1436.00
IUUC-Rno-105573 Rattus norvegicus 88.66 0.00e+00 1353.00
IUUC-Sha-107495 Sarcophilus harrisii 72.47 0.00e+00 892.00
IUUC-Sar-113545 Sorex araneus 77.68 0.00e+00 1110.00
IUUC-Ssc-115962 Sus scrofa 93.79 0.00e+00 1456.00
IUUC-Tgu-116731 Taeniopygia guttata 69.69 0.00e+00 980.00
IUUC-Tru-117893 Takifugu rubripes 46.14 1.00e-158 553.00
IUUC-Tsy-119644 Tarsius syrichta 84.44 0.00e+00 1256.00
IUUC-Tni-119819 Tetraodon nigroviridis 45.21 1.00e-168 586.00
IUUC-Tbe-127272 Tupaia belangeri 88.48 0.00e+00 1256.00
IUUC-Ttr-128404 Tursiops truncatus 93.49 0.00e+00 1447.00
IUUC-Vpa-130205 Vicugna pacos 92.86 0.00e+00 1434.00
IUUC-Xtr-132613 Xenopus tropicalis 56.25 0.00e+00 747.00
Created Date 25-Jun-2017

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