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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045814
Ensembl Protein ID ENSP00000440190.1
UniProt Accession Q9H7E2; B2MWP9; Q53XA6; Q6P992; TDRD3_HUMAN
Genbank Protein ID ACC94142.1; BAB14950.1; CAD97894.1; CAH72281.1; CAH72281.1; CAH74000.1; CAH74000.1; EAW52079.1; AAH30514.1; AAH60876.1
Protein Name Tudor domain-containing protein 3
Genbank Nucleotide ID EU643838; AK024660; BX537910; AL354764; AL512666; AL512666; AL354764; CH471124; BC030514; BC060876
Gene Name TDRD3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000083544.13 ENST00000484389.6 ENSP00000432703.1
ENSG00000083544.13 ENST00000535286.5 ENSP00000440190.1
ENSG00000083544.13 ENST00000621840.4 ENSP00000477993.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 18664458
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 4.20e-08 34.7 288 325
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
           de +l  ++eMGF++e+ +qaL +++nnleaA++ Ll+
   Q: 288  DEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLT 325
           78999*******************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Protein Sequence
(Fasta)
MAQVAGAALS QAGWYLSDEG IEACTSSPDK VNVNDIILIA LNTDLRTIGK KFLPSDINSG 60
KVEKLEGPCV LQIQKIRNVA APKDNEESQA APRMLRLQMT DGHISCTAVE FSYMSKISLN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045814|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCACCCTG CGCCCCAGCC CTCTACAGCG CGGGCGAAGG GCATCGGCGG GGAAGCGGCT 60
GTGGTTGCCA GATCTGGCAG TACAGAGCCA AGGTGGCAGG GCCGCGCTAG GACACGGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045814|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR013894--RMI1_N
IPR002999--Tudor
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50304--TUDOR
PS50030--UBA
Pfam

PF08585--RMI1_N
PF00567--TUDOR
PF00627--UBA
SMART

SM00333--TUDOR
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0016569--P:covalent chromatin modification
KEGG hsa:81550
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000323 Aegilops tauschii 31.51 1.00e-15 77.80
IUUC-Aml-001751 Ailuropoda melanoleuca 92.49 0.00e+00 1316.00
IUUC-Atr-002788 Amborella trichopoda 31.75 5.00e-21 95.90
IUUC-Apl-004055 Anas platyrhynchos 76.25 0.00e+00 952.00
IUUC-Aca-004367 Anolis carolinensis 72.89 0.00e+00 1033.00
IUUC-Aly-006072 Arabidopsis lyrata 36.31 7.00e-23 101.00
IUUC-Ath-007491 Arabidopsis thaliana 35.67 2.00e-22 100.00
IUUC-Ame-011439 Astyanax mexicanus 50.26 2.00e-160 559.00
IUUC-Bta-012894 Bos taurus 88.84 0.00e+00 1295.00
IUUC-Bdi-014462 Brachypodium distachyon 31.05 4.00e-21 95.90
IUUC-Bol-015343 Brassica oleracea 38.82 3.00e-23 103.00
IUUC-Bra-016787 Brassica rapa 37.11 7.00e-23 101.00
IUUC-Cel-018154 Caenorhabditis elegans 33.06 8.00e-28 119.00
IUUC-Cja-019364 Callithrix jacchus 95.39 0.00e+00 1201.00
IUUC-Cfa-021166 Canis familiaris 91.13 0.00e+00 1277.00
IUUC-Cpo-021678 Cavia porcellus 83.20 0.00e+00 966.00
IUUC-Csa-023299 Chlorocebus sabaeus 97.85 0.00e+00 1459.00
IUUC-Cho-024694 Choloepus hoffmanni 96.17 4.00e-140 491.00
IUUC-Cin-025191 Ciona intestinalis 42.24 4.00e-44 171.00
IUUC-Csv-026348 Ciona savignyi 52.94 2.00e-12 63.90
IUUC-Dre-028715 Danio rerio 50.46 3.00e-172 598.00
IUUC-Dno-030091 Dasypus novemcinctus 88.44 0.00e+00 1308.00
IUUC-Dor-030807 Dipodomys ordii 80.18 0.00e+00 986.00
IUUC-Dse-031459 Dothistroma septosporum 23.83 1.00e-02 35.80
IUUC-Dme-031770 Drosophila melanogaster 32.98 3.00e-43 170.00
IUUC-Ete-032507 Echinops telfairi 67.78 0.00e+00 688.00
IUUC-Eca-033406 Equus caballus 91.10 0.00e+00 1036.00
IUUC-Eeu-034600 Erinaceus europaeus 81.41 0.00e+00 967.00
IUUC-Fca-035916 Felis catus 92.19 0.00e+00 1310.00
IUUC-Fal-036658 Ficedula albicollis 74.50 0.00e+00 1000.00
IUUC-Gmo-038974 Gadus morhua 55.96 1.00e-103 370.00
IUUC-Gga-040195 Gallus gallus 75.60 0.00e+00 1070.00
IUUC-Gac-042537 Gasterosteus aculeatus 47.37 1.00e-164 573.00
IUUC-Gma-044234 Glycine max 35.57 7.00e-25 108.00
IUUC-Ggo-044715 Gorilla gorilla 98.62 0.00e+00 1293.00
IUUC-Hvu-047365 Hordeum vulgare 30.00 4.00e-16 79.70
IUUC-Itr-047866 Ictidomys tridecemlineatus 91.51 0.00e+00 1310.00
IUUC-Lch-050393 Latimeria chalumnae 62.42 0.00e+00 816.00
IUUC-Lpe-050691 Leersia perrieri 32.91 7.00e-20 91.70
IUUC-Loc-052859 Lepisosteus oculatus 57.96 0.00e+00 715.00
IUUC-Laf-053953 Loxodonta africana 88.14 0.00e+00 859.00
IUUC-Mcc-055846 Macaca mulatta 97.53 0.00e+00 1428.00
IUUC-Meu-056790 Macropus eugenii 69.63 0.00e+00 859.00
IUUC-Mtr-058749 Medicago truncatula 36.18 1.00e-21 97.80
IUUC-Mla-058959 Melampsora laricipopulina 39.71 3.00e-06 46.20
IUUC-Mga-059656 Meleagris gallopavo 74.33 0.00e+00 994.00
IUUC-Mmr-061089 Microcebus murinus 91.69 0.00e+00 1285.00
IUUC-Mdo-063043 Monodelphis domestica 69.27 0.00e+00 748.00
IUUC-Mmu-063654 Mus musculus 84.95 0.00e+00 1198.00
IUUC-Mac-064947 Musa acuminata 34.57 5.00e-20 92.40
IUUC-Mpu-066115 Mustela putorius furo 91.52 0.00e+00 1054.00
IUUC-Mlu-066974 Myotis lucifugus 85.35 0.00e+00 1170.00
IUUC-Nle-069184 Nomascus leucogenys 98.66 0.00e+00 1469.00
IUUC-Opr-070770 Ochotona princeps 81.87 0.00e+00 1028.00
IUUC-Ont-072040 Oreochromis niloticus 60.23 2.00e-141 496.00
IUUC-Oan-073448 Ornithorhynchus anatinus 84.66 2.00e-69 255.00
IUUC-Ocu-074405 Oryctolagus cuniculus 93.01 0.00e+00 1342.00
IUUC-Oba-075977 Oryza barthii 30.10 2.00e-13 70.10
IUUC-Obr-076298 Oryza brachyantha 30.96 2.00e-18 87.40
IUUC-Ogl-077706 Oryza glaberrima 30.61 2.00e-13 70.90
IUUC-Ogu-078381 Oryza glumaepatula 30.00 5.00e-14 72.00
IUUC-Oin-080150 Oryza indica 31.00 5.00e-14 72.40
IUUC-Ome-081153 Oryza meridionalis 29.69 2.00e-13 70.10
IUUC-Oni-083115 Oryza nivara 30.50 1.00e-13 70.90
IUUC-Opu-083860 Oryza punctata 30.65 7.00e-19 88.60
IUUC-Oru-084859 Oryza rufipogon 31.00 1.00e-13 71.20
IUUC-Osa-085567 Oryza sativa 31.00 1.00e-12 67.40
IUUC-Ola-087049 Oryzias latipes 47.67 2.00e-170 593.00
IUUC-Oga-088455 Otolemur garnettii 92.07 0.00e+00 1349.00
IUUC-Oar-090096 Ovis aries 90.96 0.00e+00 1316.00
IUUC-Ptr-090974 Pan troglodytes 99.39 0.00e+00 1308.00
IUUC-Pan-092657 Papio anubis 97.45 0.00e+00 1456.00
IUUC-Psi-093113 Pelodiscus sinensis 75.96 0.00e+00 942.00
IUUC-Ppa-095466 Physcomitrella patens 37.93 4.00e-23 102.00
IUUC-Pfo-096631 Poecilia formosa 48.07 1.00e-167 583.00
IUUC-Pab-098070 Pongo abelii 99.06 0.00e+00 1476.00
IUUC-Pop-099235 Populus trichocarpa 35.43 2.00e-22 100.00
IUUC-Pca-101032 Procavia capensis 82.95 0.00e+00 1062.00
IUUC-Ppe-101793 Prunus persica 32.49 4.00e-23 102.00
IUUC-Pva-102290 Pteropus vampyrus 90.02 0.00e+00 1162.00
IUUC-Rno-105080 Rattus norvegicus 84.18 0.00e+00 998.00
IUUC-Sce-106191 Saccharomyces cerevisiae 40.00 4.00e-03 37.00
IUUC-Sha-107598 Sarcophilus harrisii 79.43 0.00e+00 1127.00
IUUC-Sit-110735 Setaria italica 31.00 2.00e-19 90.50
IUUC-Sly-111126 Solanum lycopersicum 41.45 5.00e-21 95.50
IUUC-Stu-112780 Solanum tuberosum 34.95 1.00e-24 107.00
IUUC-Sar-113418 Sorex araneus 87.58 0.00e+00 1087.00
IUUC-Sbi-113925 Sorghum bicolor 30.77 3.00e-20 93.20
IUUC-Sre-114917 Sporisorium reilianum 38.55 3.00e-07 50.10
IUUC-Ssc-115712 Sus scrofa 91.81 0.00e+00 1355.00
IUUC-Tgu-117148 Taeniopygia guttata 75.64 0.00e+00 1056.00
IUUC-Tru-117831 Takifugu rubripes 46.58 1.00e-160 560.00
IUUC-Tsy-118917 Tarsius syrichta 91.09 0.00e+00 1116.00
IUUC-Tni-120783 Tetraodon nigroviridis 56.92 5.00e-129 455.00
IUUC-Tca-121430 Theobroma cacao 37.13 3.00e-09 56.60
IUUC-Tae-123752 Triticum aestivum 31.38 8.00e-16 78.20
IUUC-Tur-126238 Triticum urartu 31.58 1.00e-15 77.40
IUUC-Ttr-128615 Tursiops truncatus 85.54 0.00e+00 1073.00
IUUC-Vpa-130531 Vicugna pacos 91.71 0.00e+00 1186.00
IUUC-Vvi-131607 Vitis vinifera 39.74 2.00e-17 84.00
IUUC-Xtr-132787 Xenopus tropicalis 59.39 0.00e+00 750.00
IUUC-Xma-133815 Xiphophorus maculatus 47.99 1.00e-167 583.00
Created Date 25-Jun-2017

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