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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063654
Ensembl Protein ID ENSMUSP00000129019.1
UniProt Accession Q91W18; E9Q2Q4; Q6NZG7; Q8BZW6; Q8C1A4; TDRD3_MOUSE
Genbank Protein ID BAC26033.1; BAC28263.1; AAH05670.3; AAH66144.1
Protein Name Tudor domain-containing protein 3
Genbank Nucleotide ID AK028617; AK033390; AC154562; BC066144
Gene Name Tdrd3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022019.15 ENSMUST00000169504.7 ENSMUSP00000131542.1
ENSMUSG00000022019.15 ENSMUST00000168275.7 ENSMUSP00000129019.1
ENSMUSG00000022019.15 ENSMUST00000170865.7 ENSMUSP00000126189.1
ENSMUSG00000022019.15 ENSMUST00000170712.7 ENSMUSP00000126212.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBA 8.90e-07 30.0 288 325
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLld 40
           de +l  ++eMGF++e+ +qaL ++ nnleaA++ Ll+
   Q: 288  DEKALKHITEMGFSKEASRQALMDNANNLEAALNVLLN 325
           78999*******************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity).
 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity).
Protein Sequence
(Fasta)
MAEVSGAALS QAGWYLSDEG VEACTSSPGK GSINDIILIA LNTDLRTIGK KFLPSDINGG 60
KVEKLEGPCV LQIQKVRNVA APKDNEESQA APRMLRVQMT DGHTSCTAVE FSYISKISLN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063654|UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCATGCCC AGTGGCACAG TCGAACAGAG GAGTTTTTTT TTCTTTTTCT TTTCTTTCTT 60
CTTTTTTTCC CCCTCTTTCT TCTTTTTCTT TTTTCTGGGT CTCCAGTAGG AGGCCCGTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063654|UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR033472--DUF1767
IPR013894--RMI1_N
IPR010304--Survival_motor_neuron
IPR002999--Tudor
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50304--TUDOR
PS50030--UBA
Pfam

PF08585--RMI1_N
PF06003--SMN
PF00627--UBA
SMART

SM01161--DUF1767
SM00333--TUDOR
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035145--C:exon-exon junction complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0016569--P:covalent chromatin modification
GO:0006397--P:mRNA processing
KEGG mmu:219249
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000323 Aegilops tauschii 34.88 1.00e-15 77.00
IUUC-Aml-001751 Ailuropoda melanoleuca 84.43 0.00e+00 1176.00
IUUC-Atr-002788 Amborella trichopoda 31.22 8.00e-20 91.70
IUUC-Apl-004055 Anas platyrhynchos 70.38 0.00e+00 865.00
IUUC-Aca-004367 Anolis carolinensis 67.79 0.00e+00 959.00
IUUC-Aly-006072 Arabidopsis lyrata 34.74 6.00e-23 102.00
IUUC-Ath-007491 Arabidopsis thaliana 34.74 1.00e-22 100.00
IUUC-Ame-011439 Astyanax mexicanus 49.68 3.00e-160 558.00
IUUC-Bta-012894 Bos taurus 80.51 0.00e+00 1145.00
IUUC-Bdi-014462 Brachypodium distachyon 32.29 5.00e-21 95.50
IUUC-Bol-015343 Brassica oleracea 36.84 7.00e-22 98.20
IUUC-Bra-016787 Brassica rapa 36.24 6.00e-21 95.10
IUUC-Cel-018154 Caenorhabditis elegans 33.47 3.00e-28 120.00
IUUC-Cja-019364 Callithrix jacchus 83.56 0.00e+00 1043.00
IUUC-Cfa-021166 Canis familiaris 82.60 0.00e+00 1145.00
IUUC-Cpo-021678 Cavia porcellus 75.86 0.00e+00 860.00
IUUC-Csa-023299 Chlorocebus sabaeus 84.27 0.00e+00 1247.00
IUUC-Cho-024694 Choloepus hoffmanni 86.76 3.00e-126 446.00
IUUC-Cin-025191 Ciona intestinalis 41.38 5.00e-43 167.00
IUUC-Csv-026348 Ciona savignyi 49.02 1.00e-11 60.80
IUUC-Dre-028715 Danio rerio 49.80 1.00e-170 593.00
IUUC-Dno-030091 Dasypus novemcinctus 81.45 0.00e+00 1185.00
IUUC-Dor-030807 Dipodomys ordii 74.50 0.00e+00 894.00
IUUC-Dme-031770 Drosophila melanogaster 32.72 5.00e-46 179.00
IUUC-Ete-032507 Echinops telfairi 61.47 2.00e-173 602.00
IUUC-Eca-033406 Equus caballus 82.36 0.00e+00 912.00
IUUC-Eeu-034600 Erinaceus europaeus 74.35 0.00e+00 872.00
IUUC-Fca-035916 Felis catus 84.38 0.00e+00 1174.00
IUUC-Fal-036658 Ficedula albicollis 69.35 0.00e+00 926.00
IUUC-Gmo-038974 Gadus morhua 57.89 1.00e-102 367.00
IUUC-Gga-040195 Gallus gallus 69.97 0.00e+00 989.00
IUUC-Gac-042537 Gasterosteus aculeatus 57.89 3.00e-126 446.00
IUUC-Gma-044234 Glycine max 31.53 4.00e-22 99.40
IUUC-Ggo-044715 Gorilla gorilla 83.15 0.00e+00 1066.00
IUUC-Hsa-045814 Homo sapiens 84.95 0.00e+00 1253.00
IUUC-Hvu-047365 Hordeum vulgare 31.77 3.00e-17 83.20
IUUC-Itr-047866 Ictidomys tridecemlineatus 84.25 0.00e+00 1189.00
IUUC-Lch-050393 Latimeria chalumnae 60.69 0.00e+00 786.00
IUUC-Lpe-050691 Leersia perrieri 33.97 2.00e-20 93.60
IUUC-Loc-052859 Lepisosteus oculatus 56.90 0.00e+00 696.00
IUUC-Laf-053953 Loxodonta africana 81.23 0.00e+00 766.00
IUUC-Mcc-055846 Macaca mulatta 84.93 0.00e+00 1227.00
IUUC-Meu-056790 Macropus eugenii 65.49 0.00e+00 788.00
IUUC-Mtr-058749 Medicago truncatula 32.81 9.00e-20 91.30
IUUC-Mla-058959 Melampsora laricipopulina 44.12 1.00e-07 50.40
IUUC-Mga-059656 Meleagris gallopavo 69.49 0.00e+00 919.00
IUUC-Mmr-061089 Microcebus murinus 82.83 0.00e+00 1140.00
IUUC-Mdo-063043 Monodelphis domestica 64.98 0.00e+00 683.00
IUUC-Mac-064947 Musa acuminata 34.57 2.00e-18 87.00
IUUC-Mpu-066115 Mustela putorius furo 82.54 0.00e+00 916.00
IUUC-Mlu-066974 Myotis lucifugus 78.52 0.00e+00 1050.00
IUUC-Nle-069184 Nomascus leucogenys 84.27 0.00e+00 1245.00
IUUC-Opr-070770 Ochotona princeps 74.81 0.00e+00 920.00
IUUC-Ont-072040 Oreochromis niloticus 61.42 3.00e-140 492.00
IUUC-Oan-073448 Ornithorhynchus anatinus 81.38 1.00e-64 238.00
IUUC-Ocu-074405 Oryctolagus cuniculus 84.81 0.00e+00 1207.00
IUUC-Oba-075977 Oryza barthii 31.09 1.00e-13 70.50
IUUC-Obr-076298 Oryza brachyantha 31.78 2.00e-20 93.60
IUUC-Ogl-077706 Oryza glaberrima 29.03 7.00e-14 71.60
IUUC-Ogu-078381 Oryza glumaepatula 31.47 2.00e-14 73.60
IUUC-Oin-080150 Oryza indica 31.47 3.00e-14 72.80
IUUC-Ome-081153 Oryza meridionalis 29.64 4.00e-14 72.40
IUUC-Oni-083115 Oryza nivara 31.47 1.00e-13 70.90
IUUC-Opu-083860 Oryza punctata 31.63 2.00e-19 90.50
IUUC-Oru-084859 Oryza rufipogon 31.47 6.00e-14 72.00
IUUC-Osa-085567 Oryza sativa 28.80 5.00e-13 68.90
IUUC-Ola-087049 Oryzias latipes 56.01 3.00e-130 459.00
IUUC-Olu-087829 Ostreococcus lucimarinus 46.43 1.40e+00 26.60
IUUC-Oga-088455 Otolemur garnettii 83.47 0.00e+00 1211.00
IUUC-Oar-090096 Ovis aries 82.88 0.00e+00 1177.00
IUUC-Ptr-090974 Pan troglodytes 84.02 0.00e+00 1085.00
IUUC-Pan-092657 Papio anubis 84.54 0.00e+00 1251.00
IUUC-Psi-093113 Pelodiscus sinensis 69.37 0.00e+00 856.00
IUUC-Ppa-095466 Physcomitrella patens 35.17 3.00e-22 99.80
IUUC-Pfo-096631 Poecilia formosa 59.73 2.00e-133 469.00
IUUC-Pab-098070 Pongo abelii 84.41 0.00e+00 1246.00
IUUC-Pop-099235 Populus trichocarpa 34.29 8.00e-21 95.10
IUUC-Pca-101032 Procavia capensis 74.81 0.00e+00 937.00
IUUC-Ppe-101793 Prunus persica 31.37 6.00e-22 98.60
IUUC-Pva-102290 Pteropus vampyrus 82.64 0.00e+00 1036.00
IUUC-Rno-105080 Rattus norvegicus 89.86 0.00e+00 1038.00
IUUC-Sha-107598 Sarcophilus harrisii 75.34 0.00e+00 1052.00
IUUC-Smo-109586 Selaginella moellendorffii 36.36 1.80e-02 33.50
IUUC-Sit-110735 Setaria italica 32.49 1.00e-19 90.90
IUUC-Sly-111126 Solanum lycopersicum 39.07 5.00e-20 92.00
IUUC-Stu-112780 Solanum tuberosum 33.87 3.00e-23 102.00
IUUC-Sar-113418 Sorex araneus 81.29 0.00e+00 981.00
IUUC-Sbi-113925 Sorghum bicolor 32.49 7.00e-21 95.10
IUUC-Sre-114917 Sporisorium reilianum 39.76 6.00e-08 52.00
IUUC-Ssc-115712 Sus scrofa 84.30 0.00e+00 1218.00
IUUC-Tgu-117148 Taeniopygia guttata 70.95 0.00e+00 981.00
IUUC-Tru-117831 Takifugu rubripes 60.19 4.00e-126 445.00
IUUC-Tsy-118917 Tarsius syrichta 82.03 0.00e+00 982.00
IUUC-Tni-120783 Tetraodon nigroviridis 57.62 9.00e-128 451.00
IUUC-Tca-121430 Theobroma cacao 34.69 2.00e-08 53.90
IUUC-Tae-123752 Triticum aestivum 34.88 1.00e-15 77.80
IUUC-Tur-126238 Triticum urartu 31.77 7.00e-16 78.20
IUUC-Ttr-128615 Tursiops truncatus 77.08 0.00e+00 939.00
IUUC-Vpa-130531 Vicugna pacos 83.72 0.00e+00 1050.00
IUUC-Vvi-131607 Vitis vinifera 38.00 8.00e-17 81.30
IUUC-Xtr-132787 Xenopus tropicalis 56.52 0.00e+00 701.00
IUUC-Xma-133815 Xiphophorus maculatus 48.41 3.00e-164 572.00
Created Date 25-Jun-2017

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