iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072285

Ensembl Protein ID

ENSONIP00000006146.1

UniProt Accession

I3JBA6; I3JBA6_ORENI

Genbank Protein ID

ENSONIP00000006146

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01026456

Gene Name

herc2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000004888.1	ENSONIT00000006150.1	ENSONIP00000006146.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-85	286.8	4465	4794

Active Site

Position(s)	Description	Evidence
4763	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn+ ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4465 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNALTPLLIVTPNGRDESGANRDCFLLNPaaksaLHMSMFRFLGVLLGIAIRTGSPL 4551
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ +  e ++l+l f+     +++++ +++  +++  ++t eN+ eYv+
   Q: 4552 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATPEEFEALTLPFT-----VPNASGQDIQLSSKYSHITLENRAEYVR 4633
           ***************************************999999999*****9.....7889999999****************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFw+v+e+fs++er+
   Q: 4634 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPTAPLIQWFWDVMESFSNTERS 4718
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4719 LFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4794
           *************.8*************999988888***********************************99875 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MPSPSFTLDA QLRFHDKWLK IDLQRAFSPE GLSEMWNEMV KDEEITFNGE ESAHPEDCTD 60
CFGAQKKDEP NDKEKKEEEE TSTSVHHSII ETWDWGRQPD EKELKDCLMV LVEDQQKLSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCTC CATCATTTAC CCTCGATGCT CAGCTGAGAT TTCATGACAA ATGGCTGAAG 60
ATAGACCTGC AGGTATGTAC ACGAGAAGGA GGCAGTGGCA CGAAATAACA TTTATCGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR000859--CUB_dom
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	84.57	0.00e+00	6334.00
IUUC-Atr-003065	Amborella trichopoda	33.61	8.00e-50	192.00
IUUC-Apl-003983	Anas platyrhynchos	85.76	0.00e+00	7826.00
IUUC-Aca-004300	Anolis carolinensis	85.42	0.00e+00	7705.00
IUUC-Aly-006545	Arabidopsis lyrata	35.11	2.00e-48	188.00
IUUC-Ame-010621	Astyanax mexicanus	92.91	0.00e+00	7499.00
IUUC-Bta-013067	Bos taurus	82.71	0.00e+00	7464.00
IUUC-Bdi-014093	Brachypodium distachyon	33.51	2.00e-49	191.00
IUUC-Bol-015203	Brassica oleracea	35.11	1.00e-52	202.00
IUUC-Bra-016737	Brassica rapa	34.83	9.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	82.09	0.00e+00	7321.00
IUUC-Cfa-020672	Canis familiaris	83.09	0.00e+00	7536.00
IUUC-Cpo-021819	Cavia porcellus	80.52	0.00e+00	7264.00
IUUC-Csa-023817	Chlorocebus sabaeus	82.96	0.00e+00	7448.00
IUUC-Cho-024387	Choloepus hoffmanni	85.78	0.00e+00	1728.00
IUUC-Cin-025709	Ciona intestinalis	53.91	0.00e+00	2224.00
IUUC-Csv-026336	Ciona savignyi	36.26	0.00e+00	1484.00
IUUC-Dre-027717	Danio rerio	91.00	0.00e+00	8021.00
IUUC-Dno-029296	Dasypus novemcinctus	83.58	0.00e+00	7494.00
IUUC-Dor-030979	Dipodomys ordii	78.97	0.00e+00	2501.00
IUUC-Dme-032171	Drosophila melanogaster	59.87	0.00e+00	1562.00
IUUC-Ete-032687	Echinops telfairi	76.57	0.00e+00	2329.00
IUUC-Eca-034046	Equus caballus	82.17	0.00e+00	7441.00
IUUC-Eeu-034859	Erinaceus europaeus	87.76	0.00e+00	1823.00
IUUC-Fca-036262	Felis catus	83.17	0.00e+00	7535.00
IUUC-Fal-037562	Ficedula albicollis	85.81	0.00e+00	7783.00
IUUC-Gmo-039054	Gadus morhua	91.86	0.00e+00	1149.00
IUUC-Gga-040359	Gallus gallus	85.93	0.00e+00	7796.00
IUUC-Gac-041879	Gasterosteus aculeatus	94.84	0.00e+00	1102.00
IUUC-Ggo-044692	Gorilla gorilla	90.18	0.00e+00	4053.00
IUUC-Hsa-045995	Homo sapiens	82.85	0.00e+00	7489.00
IUUC-Hvu-047529	Hordeum vulgare	35.38	5.00e-49	190.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	77.90	0.00e+00	1952.00
IUUC-Lch-049808	Latimeria chalumnae	87.77	0.00e+00	3377.00
IUUC-Lpe-051482	Leersia perrieri	33.68	3.00e-46	181.00
IUUC-Loc-052685	Lepisosteus oculatus	90.70	0.00e+00	8056.00
IUUC-Laf-053372	Loxodonta africana	82.91	0.00e+00	7460.00
IUUC-Mcc-054693	Macaca mulatta	82.87	0.00e+00	7479.00
IUUC-Meu-056660	Macropus eugenii	94.16	0.00e+00	1917.00
IUUC-Mga-059371	Meleagris gallopavo	87.43	0.00e+00	6881.00
IUUC-Mmr-060787	Microcebus murinus	83.25	0.00e+00	7533.00
IUUC-Mdo-062518	Monodelphis domestica	82.63	0.00e+00	7397.00
IUUC-Mmu-063690	Mus musculus	82.54	0.00e+00	7442.00
IUUC-Mpu-066478	Mustela putorius furo	82.53	0.00e+00	7472.00
IUUC-Mlu-067596	Myotis lucifugus	82.26	0.00e+00	4006.00
IUUC-Nle-069445	Nomascus leucogenys	79.89	0.00e+00	1755.00
IUUC-Opr-070990	Ochotona princeps	83.11	0.00e+00	2847.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.78	0.00e+00	3396.00
IUUC-Ocu-074273	Oryctolagus cuniculus	82.52	0.00e+00	7430.00
IUUC-Oba-075573	Oryza barthii	32.90	5.00e-45	176.00
IUUC-Obr-076107	Oryza brachyantha	32.10	2.00e-50	194.00
IUUC-Ogl-077193	Oryza glaberrima	32.90	4.00e-45	177.00
IUUC-Ogu-078817	Oryza glumaepatula	32.90	5.00e-45	176.00
IUUC-Oin-079609	Oryza indica	32.24	1.00e-48	188.00
IUUC-Olo-080629	Oryza longistaminata	32.90	6.00e-45	176.00
IUUC-Ome-081686	Oryza meridionalis	32.90	2.00e-45	177.00
IUUC-Opu-084137	Oryza punctata	33.16	1.00e-45	179.00
IUUC-Oru-085013	Oryza rufipogon	32.90	5.00e-45	176.00
IUUC-Osa-085597	Oryza sativa	32.90	6.00e-45	176.00
IUUC-Ola-087346	Oryzias latipes	95.28	0.00e+00	1263.00
IUUC-Oga-088742	Otolemur garnettii	83.13	0.00e+00	7408.00
IUUC-Oar-090093	Ovis aries	83.03	0.00e+00	7473.00
IUUC-Ptr-091034	Pan troglodytes	80.29	0.00e+00	5039.00
IUUC-Pan-092783	Papio anubis	81.34	0.00e+00	7296.00
IUUC-Psi-094027	Pelodiscus sinensis	86.73	0.00e+00	7536.00
IUUC-Pfo-096208	Poecilia formosa	94.69	0.00e+00	7046.00
IUUC-Pab-097681	Pongo abelii	76.28	0.00e+00	2070.00
IUUC-Pop-099121	Populus trichocarpa	35.21	7.00e-51	196.00
IUUC-Pca-100705	Procavia capensis	88.89	0.00e+00	1102.00
IUUC-Pva-103147	Pteropus vampyrus	73.52	0.00e+00	2063.00
IUUC-Rno-105458	Rattus norvegicus	82.43	0.00e+00	7424.00
IUUC-Sha-106959	Sarcophilus harrisii	76.45	0.00e+00	6483.00
IUUC-Smo-108827	Selaginella moellendorffii	33.86	2.00e-49	191.00
IUUC-Sit-109917	Setaria italica	35.50	1.00e-47	185.00
IUUC-Sly-110961	Solanum lycopersicum	34.70	3.00e-53	203.00
IUUC-Stu-112166	Solanum tuberosum	32.90	2.00e-45	178.00
IUUC-Sar-113532	Sorex araneus	78.82	0.00e+00	1691.00
IUUC-Sbi-114352	Sorghum bicolor	32.31	6.00e-49	189.00
IUUC-Ssc-115337	Sus scrofa	76.38	0.00e+00	2432.00
IUUC-Tgu-116789	Taeniopygia guttata	85.73	0.00e+00	7807.00
IUUC-Tru-118129	Takifugu rubripes	94.13	0.00e+00	8383.00
IUUC-Tsy-119302	Tarsius syrichta	76.75	0.00e+00	1131.00
IUUC-Tni-120374	Tetraodon nigroviridis	92.34	0.00e+00	8226.00
IUUC-Tca-121094	Theobroma cacao	35.31	8.00e-54	206.00
IUUC-Tae-124157	Triticum aestivum	32.98	2.00e-48	188.00
IUUC-Tur-126300	Triticum urartu	35.01	3.00e-49	191.00
IUUC-Tbe-128137	Tupaia belangeri	73.90	0.00e+00	1913.00
IUUC-Ttr-128273	Tursiops truncatus	77.08	0.00e+00	2355.00
IUUC-Vpa-130471	Vicugna pacos	75.79	0.00e+00	1344.00
IUUC-Xtr-132185	Xenopus tropicalis	82.11	0.00e+00	7380.00
IUUC-Xma-133233	Xiphophorus maculatus	95.24	0.00e+00	8430.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence