iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030994.15	ENSMUST00000172947.7	ENSMUSP00000134479.1
ENSMUSG00000030994.15	ENSMUST00000106129.8	ENSMUSP00000101735.2
ENSMUSG00000030994.15	ENSMUST00000174700.1	ENSMUSP00000134411.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	24240685

Organism

Mus musculus

Functional Description
(View)

Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. May have a role in the assembly of primary cilia.

Protein Sequence
(Fasta)

MIKLSGEGLL HTCYSTNDQI ALKNLQSDVT ERKLDFSKET LASQNTRMIS PVVISRLIDE 60
KKSMENGAIL PQAIAQPQLC PTKPALARRD GVSMHRRFAL SPDRLGILTP SDDQGLETEP 120

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Nucleotide Sequence
(Fasta)

ACTACTTCAG GATTCCAGCT TATACAGGAG AGCAGCTGAA ACAAGTAGTC TCGTGGGACT 60
GAGCAACTAC TAGATTTTTG GATTTCCCAT TCACAGCTAC CCATTGTTGG GTTCGTTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0043--Tumor suppressor

Interpro

IPR029299--ALMS_motif
IPR029561--C10orf90

Pfam

PF15309--ALMS_motif

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0051393--F:alpha-actinin binding
GO:0042826--F:histone deacetylase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0030308--P:negative regulation of cell growth
GO:0050821--P:protein stabilization
GO:0010212--P:response to ionizing radiation
GO:0009411--P:response to UV

KEGG

mmu:71007

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001833	Ailuropoda melanoleuca	59.14	0.00e+00	663.00
IUUC-Apl-003559	Anas platyrhynchos	70.45	2.00e-38	150.00
IUUC-Aca-005337	Anolis carolinensis	39.92	2.00e-38	152.00
IUUC-Ame-011899	Astyanax mexicanus	75.00	1.00e-24	104.00
IUUC-Bta-013353	Bos taurus	60.11	0.00e+00	685.00
IUUC-Cja-019286	Callithrix jacchus	65.57	0.00e+00	769.00
IUUC-Cfa-020500	Canis familiaris	53.22	6.00e-148	517.00
IUUC-Cpo-022008	Cavia porcellus	62.57	0.00e+00	789.00
IUUC-Csa-023064	Chlorocebus sabaeus	65.52	0.00e+00	796.00
IUUC-Cho-024514	Choloepus hoffmanni	53.21	5.00e-82	298.00
IUUC-Dno-029300	Dasypus novemcinctus	45.32	8.00e-73	267.00
IUUC-Dor-030427	Dipodomys ordii	44.43	3.00e-84	305.00
IUUC-Dse-031447	Dothistroma septosporum	29.17	9.00e-03	35.80
IUUC-Ete-032875	Echinops telfairi	39.15	6.00e-52	199.00
IUUC-Eca-034005	Equus caballus	62.23	0.00e+00	766.00
IUUC-Eeu-035334	Erinaceus europaeus	51.31	5.00e-38	152.00
IUUC-Fca-036078	Felis catus	54.02	7.00e-175	607.00
IUUC-Fal-037368	Ficedula albicollis	66.42	2.00e-36	145.00
IUUC-Gga-041090	Gallus gallus	70.31	1.00e-37	148.00
IUUC-Ggo-045310	Gorilla gorilla	65.22	0.00e+00	797.00
IUUC-Hsa-046064	Homo sapiens	65.19	0.00e+00	808.00
IUUC-Hvu-047453	Hordeum vulgare	26.76	1.30e-01	30.00
IUUC-Itr-048926	Ictidomys tridecemlineatus	63.04	0.00e+00	755.00
IUUC-Loc-052489	Lepisosteus oculatus	74.36	5.00e-21	92.40
IUUC-Laf-053440	Loxodonta africana	53.17	9.00e-159	553.00
IUUC-Mcc-055047	Macaca mulatta	65.71	0.00e+00	799.00
IUUC-Meu-056566	Macropus eugenii	48.56	9.00e-137	480.00
IUUC-Mga-059641	Meleagris gallopavo	39.94	4.00e-89	322.00
IUUC-Mmr-061488	Microcebus murinus	57.04	2.00e-115	409.00
IUUC-Mdo-062611	Monodelphis domestica	45.38	9.00e-130	457.00
IUUC-Mpu-066208	Mustela putorius furo	54.91	2.00e-151	529.00
IUUC-Mlu-066943	Myotis lucifugus	44.87	1.00e-72	266.00
IUUC-Nle-069500	Nomascus leucogenys	65.57	0.00e+00	783.00
IUUC-Opr-070781	Ochotona princeps	52.72	6.00e-168	584.00
IUUC-Ocu-074617	Oryctolagus cuniculus	67.37	4.00e-83	301.00
IUUC-Ola-086910	Oryzias latipes	73.33	1.00e-20	90.90
IUUC-Oga-089026	Otolemur garnettii	60.66	0.00e+00	720.00
IUUC-Oar-089197	Ovis aries	59.89	0.00e+00	697.00
IUUC-Ptr-090985	Pan troglodytes	65.05	0.00e+00	805.00
IUUC-Pan-092432	Papio anubis	65.42	0.00e+00	793.00
IUUC-Psi-093653	Pelodiscus sinensis	42.37	3.00e-116	412.00
IUUC-Pab-098049	Pongo abelii	61.04	1.00e-120	426.00
IUUC-Pca-101082	Procavia capensis	74.74	4.00e-62	233.00
IUUC-Pva-102848	Pteropus vampyrus	56.63	0.00e+00	643.00
IUUC-Pte-104270	Pyrenophora teres	30.91	9.20e-02	30.40
IUUC-Pyt-104461	Pyrenophora triticirepentis	30.91	9.50e-02	30.40
IUUC-Rno-105154	Rattus norvegicus	87.16	0.00e+00	1095.00
IUUC-Sha-107583	Sarcophilus harrisii	40.10	2.00e-68	253.00
IUUC-Ssc-116095	Sus scrofa	60.79	0.00e+00	696.00
IUUC-Tsy-118864	Tarsius syrichta	59.46	1.00e-119	424.00
IUUC-Tvi-122275	Trichoderma virens	30.23	5.50e-01	28.50
IUUC-Tbe-127637	Tupaia belangeri	61.87	0.00e+00	709.00
IUUC-Ttr-128508	Tursiops truncatus	61.20	0.00e+00	680.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence