iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027369

UUCD1 version

UUC-DaR-01203

Ensembl Protein ID

ENSDARP00000100739.2

UniProt Accession

Q68EK9; A2CES9; CDC26_DANRE

Genbank Protein ID

ABD22986.1; CAM15227.1; AAH80217.1

Protein Name

Anaphase-promoting complex subunit CDC26; Cell division cycle protein 26 homolog

Genbank Nucleotide ID

DQ352177; CR759821; BC080217

Gene Name

cdc26; si:dkey-190c14.5; zgc:100965

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000077815.3	ENSDART00000112793.3	ENSDARP00000100739.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	63.64	2.00e-26	114.00	IUUC-Hsa-046899

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Protein Sequence
(Fasta)

MLRRKPTRLE LKLDDTEEFE SVKKELESRK KQRDEVDVVG VATSSEMSGA AGGTADGKTR 60
EQMIHERIGY KPHPKPNTLP SLFGNLQF 88

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Nucleotide Sequence
(Fasta)

AAACTACATT TCCCATGATT CCTTCTGCTC TTTCTACGGT CTAAAGCGTG AATAATTACG 60
GTAAGTGATG TGAGCTGAAA TAGTCATCTT CTTTCAGTTT AGAATTGTTT GTCAATAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR018860--APC_suCDC26

Pfam

PF10471--ANAPC_CDC26

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0007346--P:regulation of mitotic cell cycle
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

dre:445501

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001456	Ailuropoda melanoleuca	65.91	3.00e-29	119.00
IUUC-Atr-002458	Amborella trichopoda	60.87	5.00e-03	32.30
IUUC-Aca-004376	Anolis carolinensis	69.32	2.00e-29	119.00
IUUC-Ani-009376	Aspergillus nidulans	40.00	8.90e-01	24.60
IUUC-Ame-011022	Astyanax mexicanus	92.05	2.00e-35	139.00
IUUC-Bta-012581	Bos taurus	64.77	7.00e-29	118.00
IUUC-Cja-019622	Callithrix jacchus	62.50	1.00e-27	114.00
IUUC-Cfa-021044	Canis familiaris	65.91	3.00e-29	119.00
IUUC-Cpo-022441	Cavia porcellus	59.09	5.00e-23	98.60
IUUC-Csa-024091	Chlorocebus sabaeus	62.50	2.00e-23	100.00
IUUC-Cho-025001	Choloepus hoffmanni	52.46	1.00e-12	64.30
IUUC-Csv-025958	Ciona savignyi	27.78	4.00e-05	39.30
IUUC-Dno-029137	Dasypus novemcinctus	63.64	6.00e-27	111.00
IUUC-Dor-030181	Dipodomys ordii	67.05	1.00e-29	120.00
IUUC-Ete-032555	Echinops telfairi	63.64	4.00e-28	115.00
IUUC-Eca-033227	Equus caballus	62.50	3.00e-23	99.40
IUUC-Eeu-034615	Erinaceus europaeus	57.38	8.00e-15	71.20
IUUC-Fca-035838	Felis catus	65.91	4.00e-29	119.00
IUUC-Fal-036994	Ficedula albicollis	89.66	4.00e-09	52.40
IUUC-Gga-040675	Gallus gallus	54.55	4.00e-18	82.40
IUUC-Ggo-044779	Gorilla gorilla	61.54	6.00e-10	55.50
IUUC-Hsa-046899	Homo sapiens	61.36	4.00e-23	99.00
IUUC-Itr-048643	Ictidomys tridecemlineatus	62.50	2.00e-24	103.00
IUUC-Lch-049544	Latimeria chalumnae	67.05	2.00e-29	120.00
IUUC-Loc-052390	Lepisosteus oculatus	84.09	5.00e-33	131.00
IUUC-Laf-053681	Loxodonta africana	61.36	5.00e-23	98.60
IUUC-Mcc-054912	Macaca mulatta	62.50	2.00e-23	100.00
IUUC-Meu-056222	Macropus eugenii	59.02	5.00e-15	72.00
IUUC-Mor-057242	Magnaporthe oryzae	34.38	3.80e-01	27.70
IUUC-Mmr-061790	Microcebus murinus	63.64	3.00e-28	115.00
IUUC-Mmu-064350	Mus musculus	62.50	2.00e-26	109.00
IUUC-Mlu-067848	Myotis lucifugus	60.23	4.00e-23	99.00
IUUC-Nle-069077	Nomascus leucogenys	62.50	3.00e-23	99.40
IUUC-Opr-071004	Ochotona princeps	61.36	1.00e-24	104.00
IUUC-Ont-071525	Oreochromis niloticus	58.76	9.00e-24	101.00
IUUC-Oan-073200	Ornithorhynchus anatinus	68.18	8.00e-30	121.00
IUUC-Ocu-074476	Oryctolagus cuniculus	65.91	3.00e-29	119.00
IUUC-Oba-075520	Oryza barthii	65.00	2.50e-02	30.00
IUUC-Obr-076249	Oryza brachyantha	65.00	1.70e-01	29.60
IUUC-Ogu-078445	Oryza glumaepatula	65.00	2.60e-02	30.00
IUUC-Ola-087554	Oryzias latipes	56.84	2.00e-23	100.00
IUUC-Oga-088195	Otolemur garnettii	60.23	1.00e-21	94.00
IUUC-Oar-089399	Ovis aries	64.77	1.00e-28	117.00
IUUC-Ptr-090822	Pan troglodytes	61.36	4.00e-23	99.00
IUUC-Pan-092857	Papio anubis	62.50	2.00e-23	100.00
IUUC-Ppa-095794	Physcomitrella patens	75.00	3.00e-03	33.10
IUUC-Pfo-097147	Poecilia formosa	58.51	3.00e-23	99.40
IUUC-Pab-098774	Pongo abelii	61.36	4.00e-23	99.00
IUUC-Pca-100745	Procavia capensis	61.36	2.00e-23	100.00
IUUC-Pva-102647	Pteropus vampyrus	59.09	7.00e-23	98.20
IUUC-Rno-106085	Rattus norvegicus	61.36	6.00e-26	108.00
IUUC-Sha-107235	Sarcophilus harrisii	68.18	8.00e-30	121.00
IUUC-Sar-113299	Sorex araneus	56.41	4.00e-09	52.40
IUUC-Ssc-115650	Sus scrofa	55.68	1.00e-20	90.50
IUUC-Tgu-117309	Taeniopygia guttata	57.95	4.00e-20	89.40
IUUC-Tsy-119267	Tarsius syrichta	61.36	5.00e-23	98.60
IUUC-Tni-120675	Tetraodon nigroviridis	62.50	2.00e-25	106.00
IUUC-Ttr-129250	Tursiops truncatus	61.36	4.00e-23	99.00
IUUC-Vpa-130562	Vicugna pacos	64.77	7.00e-29	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence