iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Protein Sequence
(Fasta)

MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM 60
INDRIGYKPQ PKPNNRSSQF GSLEF 85

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Nucleotide Sequence
(Fasta)

GGAGCATGAT GGAAGTCGTA GTAGGAAATG GCGTCGTGGC ATTGAGGGGC ATCCCTCCTA 60
GAACCTCCAG GAAAAGCTCG CGGAAGACGA GGTTCTGCGG AGAGAGAGGC TCCAAGCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR018860--APC_suCDC26

Pfam

PF10471--ANAPC_CDC26

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:246184

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001456	Ailuropoda melanoleuca	94.12	1.00e-41	160.00
IUUC-Atr-002458	Amborella trichopoda	35.71	2.00e-03	33.50
IUUC-Aca-004376	Anolis carolinensis	81.18	3.00e-36	142.00
IUUC-Ago-007754	Ashbya gossypii	47.62	4.80e-01	26.20
IUUC-Acl-008116	Aspergillus clavatus	52.17	1.10e-01	27.70
IUUC-Ani-009376	Aspergillus nidulans	46.67	4.80e-01	25.80
IUUC-Ame-011022	Astyanax mexicanus	59.77	3.00e-23	99.40
IUUC-Bta-012581	Bos taurus	94.12	2.00e-42	163.00
IUUC-Bci-013595	Botrytis cinerea	47.62	1.70e+00	25.40
IUUC-Cja-019622	Callithrix jacchus	96.47	2.00e-43	166.00
IUUC-Cfa-021044	Canis familiaris	94.12	1.00e-41	160.00
IUUC-Cpo-022441	Cavia porcellus	94.12	4.00e-36	142.00
IUUC-Csa-024091	Chlorocebus sabaeus	98.82	5.00e-35	138.00
IUUC-Cho-025001	Choloepus hoffmanni	91.38	5.00e-25	105.00
IUUC-Csv-025958	Ciona savignyi	26.14	4.00e-06	42.40
IUUC-Dre-027369	Danio rerio	63.64	8.00e-28	114.00
IUUC-Dno-029137	Dasypus novemcinctus	91.76	4.00e-41	158.00
IUUC-Dor-030181	Dipodomys ordii	91.76	2.00e-41	159.00
IUUC-Ete-032555	Echinops telfairi	90.59	9.00e-41	157.00
IUUC-Eca-033227	Equus caballus	95.29	9.00e-34	134.00
IUUC-Eeu-034615	Erinaceus europaeus	91.38	2.00e-26	110.00
IUUC-Fca-035838	Felis catus	91.76	2.00e-40	156.00
IUUC-Fal-036994	Ficedula albicollis	86.21	3.00e-09	52.80
IUUC-Gga-040675	Gallus gallus	65.88	2.00e-22	96.70
IUUC-Ggo-044779	Gorilla gorilla	100.00	5.00e-20	88.60
IUUC-Itr-048643	Ictidomys tridecemlineatus	91.76	1.00e-34	137.00
IUUC-Lch-049544	Latimeria chalumnae	68.24	2.00e-30	123.00
IUUC-Loc-052390	Lepisosteus oculatus	62.50	4.00e-23	99.00
IUUC-Laf-053681	Loxodonta africana	97.65	2.00e-34	136.00
IUUC-Mcc-054912	Macaca mulatta	98.82	5.00e-35	138.00
IUUC-Meu-056222	Macropus eugenii	84.48	7.00e-25	104.00
IUUC-Mor-057242	Magnaporthe oryzae	34.38	1.20e-01	29.60
IUUC-Mmr-061790	Microcebus murinus	92.94	5.00e-42	161.00
IUUC-Mmu-064350	Mus musculus	88.24	2.00e-38	149.00
IUUC-Mlu-067848	Myotis lucifugus	94.12	3.00e-35	139.00
IUUC-Nle-069077	Nomascus leucogenys	97.65	2.00e-34	136.00
IUUC-Opr-071004	Ochotona princeps	90.59	2.00e-34	136.00
IUUC-Ont-071525	Oreochromis niloticus	50.52	1.00e-17	80.90
IUUC-Oan-073200	Ornithorhynchus anatinus	89.41	6.00e-40	154.00
IUUC-Ocu-074476	Oryctolagus cuniculus	92.94	6.00e-42	161.00
IUUC-Oba-075520	Oryza barthii	61.90	4.70e-02	28.90
IUUC-Obr-076249	Oryza brachyantha	61.90	2.30e-01	28.90
IUUC-Ogu-078445	Oryza glumaepatula	61.90	4.80e-02	28.90
IUUC-Ola-087554	Oryzias latipes	51.58	3.00e-20	89.40
IUUC-Oga-088195	Otolemur garnettii	91.76	6.00e-31	124.00
IUUC-Oar-089399	Ovis aries	92.94	6.00e-42	161.00
IUUC-Ptr-090822	Pan troglodytes	100.00	2.00e-35	140.00
IUUC-Pan-092857	Papio anubis	98.82	5.00e-35	138.00
IUUC-Ppa-095794	Physcomitrella patens	75.00	7.00e-03	32.00
IUUC-Pfo-097147	Poecilia formosa	52.13	3.00e-16	76.30
IUUC-Pab-098774	Pongo abelii	100.00	2.00e-35	140.00
IUUC-Pca-100745	Procavia capensis	96.47	9.00e-34	134.00
IUUC-Pva-102647	Pteropus vampyrus	96.47	2.00e-36	142.00
IUUC-Pte-104296	Pyrenophora teres	54.17	8.20e-02	28.10
IUUC-Pyt-104747	Pyrenophora triticirepentis	54.17	6.90e-02	28.50
IUUC-Rno-106085	Rattus norvegicus	89.41	5.00e-39	151.00
IUUC-Sce-106324	Saccharomyces cerevisiae	32.73	6.70e-01	26.20
IUUC-Sha-107235	Sarcophilus harrisii	90.59	8.00e-41	157.00
IUUC-Sja-107826	Schizosaccharomyces japonicus	28.57	4.60e+00	22.30
IUUC-Spo-108195	Schizosaccharomyces pombe	28.21	3.60e-01	26.20
IUUC-Ssl-108598	Sclerotinia sclerotiorum	47.62	2.00e+00	25.00
IUUC-Sar-113299	Sorex araneus	94.83	4.00e-19	85.50
IUUC-Ssc-115650	Sus scrofa	85.88	3.00e-30	122.00
IUUC-Tgu-117309	Taeniopygia guttata	59.30	4.00e-22	95.50
IUUC-Tsy-119267	Tarsius syrichta	97.65	2.00e-34	136.00
IUUC-Tni-120675	Tetraodon nigroviridis	51.76	1.00e-19	87.40
IUUC-Tvi-122490	Trichoderma virens	47.62	4.00e-01	26.90
IUUC-Ttr-129250	Tursiops truncatus	94.12	4.00e-35	139.00
IUUC-Vpa-130562	Vicugna pacos	95.29	3.00e-42	162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence