iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	26290265

Classification

Family	E-value	Score	Start	End
DUB/USP	1.10e-62	213.1	198	550

Active Site

Position(s)	Description	Evidence
206	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
510	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel............w.kskkkavsprellkalkkeaeefs. 85
           Gl N gN C++N++LQ+L++++++ +ll + + +++++      + + l ++ ++++el            +  +  + + p ++  +l+++ + +  
   Q: 198  GLINAGNLCFLNATLQALLSCSPFVQLLQKIQLQDIPKA-----DSPTLAAFSEFISELdvpssssirnnvTvVEAGRPFRPAMFEGVLRNFTPDVLn 290
           9*****************************777777655.....4566666666666664444444444431467777*************9999553 PP
   S: 86   ....gyeqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsde................aeekkkkknkslisdlFqgqlksqikclecdnv 162
                 +q+DaqEfl+f++dq+++el k ++++pk ++++++ +++                   a  ++++  +s +s++F+gqlks +k +   + 
   Q: 291  nmsgRPRQEDAQEFLSFIMDQMHDELLKlKEQSPKVTASKSSVISS--AnddgdewetvgpknksAVTRTQSFVPSELSEIFGGQLKSVVKAKG-TKA 385
           6665668*******************55333333333333332222..134689899999977666666777777999*********9999876.567 PP
   S: 163  ssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           s + +p l l l+++ +  +    ++d+L+ f+++e leg  +  + k  + + a+k++k++kl++++ilhL+Rfs+ ++   ++k+ k v+fpleL+
   Q: 386  SATVQPYLLLHLDIHPDGVQ---GIEDALHLFSAQEDLEGYRASVTGKT-GVVSASKSIKIQKLSKIMILHLMRFSYGSQ--GSTKLRKGVKFPLELN 477
           889***************98...*****************776666665.5788*********************99886..567************* PP
   S: 261  lsp.fctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           l++ +++s ++   e+ +YeL+a + H+G  +s+GHY+++++ ++g+Wl+fdD +Vt++  + vl    ++aYvlfYk+
   Q: 478  LNRsHLVSLSN---ESLRYELVATITHHGwDPSKGHYTTDARRKNGQWLRFDDASVTPIGTKLVLH---DQAYVLFYKQ 550
           **856666443...389*************************************************...********97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MSEKKVFVFG SFTEHETRSF FEQKPTKDPQ NSKDKCVGSI QFGSLNLAAE NSSVNTNGEL 60
KKGEADGTVK SAGSQERLDA SRPASSDKNN DSDAKLPRKN SLRVPEHVVQ NGIIKEISES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACACGTGA GTTTTTAATA ACCGTTCAGA CCAAACAGGA GTAACAACAA CTGTTTGAGA 60
TAGTTTTGTT GAATAACCGA ATTAAACCAA AGTGAATACA AAACCGAACC GAGATTTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G30890

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	58.73	3.00e-116	412.00
IUUC-Aml-001584	Ailuropoda melanoleuca	34.36	9.00e-55	207.00
IUUC-Atr-002927	Amborella trichopoda	67.92	4.00e-144	504.00
IUUC-Apl-003988	Anas platyrhynchos	33.17	5.00e-50	192.00
IUUC-Aca-004461	Anolis carolinensis	34.41	1.00e-38	152.00
IUUC-Aly-006038	Arabidopsis lyrata	95.46	0.00e+00	1019.00
IUUC-Ago-007717	Ashbya gossypii	26.19	2.00e-34	140.00
IUUC-Acl-008188	Aspergillus clavatus	33.78	2.00e-51	196.00
IUUC-Afl-008456	Aspergillus flavus	38.34	1.00e-41	163.00
IUUC-Afu-009067	Aspergillus fumigatus	34.78	3.00e-53	202.00
IUUC-Ani-009483	Aspergillus nidulans	35.25	4.00e-52	199.00
IUUC-Ang-009639	Aspergillus niger	34.07	3.00e-51	196.00
IUUC-Aor-010040	Aspergillus oryzae	33.77	2.00e-51	197.00
IUUC-Ate-010310	Aspergillus terreus	33.80	9.00e-52	197.00
IUUC-Ame-011012	Astyanax mexicanus	33.02	2.00e-43	170.00
IUUC-Bgr-012311	Blumeria graminis	34.92	5.00e-39	155.00
IUUC-Bta-013299	Bos taurus	34.36	3.00e-53	202.00
IUUC-Bci-013783	Botrytis cinerea	33.15	3.00e-45	176.00
IUUC-Bdi-015039	Brachypodium distachyon	62.67	4.00e-126	444.00
IUUC-Bol-015806	Brassica oleracea	74.74	0.00e+00	826.00
IUUC-Bra-017076	Brassica rapa	77.43	0.00e+00	836.00
IUUC-Cja-018715	Callithrix jacchus	34.02	9.00e-53	201.00
IUUC-Cfa-020194	Canis familiaris	34.62	1.00e-54	207.00
IUUC-Cpo-022272	Cavia porcellus	34.81	2.00e-54	206.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	30.86	2.00e-34	139.00
IUUC-Csa-023310	Chlorocebus sabaeus	33.50	4.00e-54	205.00
IUUC-Cin-025616	Ciona intestinalis	32.13	4.00e-42	165.00
IUUC-Csv-026043	Ciona savignyi	33.16	2.00e-42	166.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	30.96	5.00e-37	149.00
IUUC-Cne-026962	Cryptococcus neoformans	28.69	2.00e-36	147.00
IUUC-Cme-027113	Cyanidioschyzon merolae	30.64	5.00e-34	138.00
IUUC-Dre-028072	Danio rerio	32.74	1.00e-53	204.00
IUUC-Dno-029489	Dasypus novemcinctus	35.66	7.00e-55	208.00
IUUC-Dor-031068	Dipodomys ordii	42.45	1.00e-24	107.00
IUUC-Dse-031553	Dothistroma septosporum	32.97	1.00e-45	177.00
IUUC-Dme-031759	Drosophila melanogaster	31.85	4.00e-47	183.00
IUUC-Ete-032549	Echinops telfairi	34.40	1.00e-32	134.00
IUUC-Eca-033380	Equus caballus	35.13	4.00e-55	209.00
IUUC-Eeu-034818	Erinaceus europaeus	35.62	6.00e-53	201.00
IUUC-Fca-035535	Felis catus	34.52	5.00e-49	188.00
IUUC-Fal-036627	Ficedula albicollis	33.75	2.00e-54	207.00
IUUC-Fox-037904	Fusarium oxysporum	34.77	4.00e-48	186.00
IUUC-Fso-038170	Fusarium solani	33.14	1.00e-41	164.00
IUUC-Gmo-039499	Gadus morhua	32.99	1.00e-48	187.00
IUUC-Ggr-040042	Gaeumannomyces graminis	35.42	1.00e-52	201.00
IUUC-Gga-040571	Gallus gallus	33.50	1.00e-51	197.00
IUUC-Gac-041345	Gasterosteus aculeatus	33.42	1.00e-49	190.00
IUUC-Gma-043436	Glycine max	55.80	5.00e-156	543.00
IUUC-Ggo-044652	Gorilla gorilla	35.13	1.00e-54	207.00
IUUC-Hsa-045864	Homo sapiens	35.13	1.00e-54	207.00
IUUC-Hvu-047071	Hordeum vulgare	62.88	2.00e-128	451.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	35.13	1.00e-54	206.00
IUUC-Kpa-049132	Komagataella pastoris	27.74	3.00e-39	155.00
IUUC-Lch-050040	Latimeria chalumnae	32.82	6.00e-52	198.00
IUUC-Lpe-050772	Leersia perrieri	49.78	3.00e-47	182.00
IUUC-Loc-052449	Lepisosteus oculatus	33.16	1.00e-53	204.00
IUUC-Lma-053248	Leptosphaeria maculans	33.61	2.00e-51	196.00
IUUC-Laf-054121	Loxodonta africana	33.59	7.00e-53	201.00
IUUC-Mcc-055514	Macaca mulatta	33.50	6.00e-54	205.00
IUUC-Meu-056873	Macropus eugenii	31.62	8.00e-25	108.00
IUUC-Mor-057243	Magnaporthe oryzae	33.98	8.00e-50	191.00
IUUC-Mpo-057439	Magnaporthe poae	33.79	1.00e-50	194.00
IUUC-Mtr-058457	Medicago truncatula	54.40	7.00e-149	520.00
IUUC-Mla-058929	Melampsora laricipopulina	30.81	3.00e-40	159.00
IUUC-Mga-060157	Meleagris gallopavo	33.42	4.00e-50	192.00
IUUC-Mvi-060442	Microbotryum violaceum	33.08	2.00e-44	174.00
IUUC-Mmr-061062	Microcebus murinus	33.50	1.00e-53	203.00
IUUC-Mdo-062798	Monodelphis domestica	33.93	5.00e-50	192.00
IUUC-Mmu-064050	Mus musculus	35.46	5.00e-58	218.00
IUUC-Mac-065619	Musa acuminata	69.35	2.00e-138	484.00
IUUC-Mpu-066554	Mustela putorius furo	33.85	1.00e-54	207.00
IUUC-Mlu-068003	Myotis lucifugus	33.59	3.00e-54	206.00
IUUC-Nfi-068612	Neosartorya fischeri	34.60	2.00e-52	200.00
IUUC-Ncr-068878	Neurospora crassa	35.11	4.00e-47	182.00
IUUC-Nle-069661	Nomascus leucogenys	35.13	1.00e-54	207.00
IUUC-Opr-070944	Ochotona princeps	34.51	9.00e-35	141.00
IUUC-Ont-071266	Oreochromis niloticus	33.67	8.00e-52	197.00
IUUC-Oan-073442	Ornithorhynchus anatinus	34.53	4.00e-56	212.00
IUUC-Ocu-073788	Oryctolagus cuniculus	34.15	2.00e-50	193.00
IUUC-Oba-075085	Oryza barthii	66.30	1.00e-97	348.00
IUUC-Obr-076663	Oryza brachyantha	62.33	1.00e-116	413.00
IUUC-Ogl-076937	Oryza glaberrima	47.44	9.00e-128	449.00
IUUC-Ogu-078909	Oryza glumaepatula	48.35	1.00e-126	446.00
IUUC-Oin-079617	Oryza indica	47.15	2.00e-121	429.00
IUUC-Olo-081043	Oryza longistaminata	57.20	1.00e-60	226.00
IUUC-Ome-081646	Oryza meridionalis	53.15	3.00e-61	228.00
IUUC-Oni-082914	Oryza nivara	48.35	7.00e-127	447.00
IUUC-Opu-083987	Oryza punctata	67.06	7.00e-26	110.00
IUUC-Oru-084878	Oryza rufipogon	48.35	6.00e-127	447.00
IUUC-Osa-085822	Oryza sativa	62.09	4.00e-126	444.00
IUUC-Ola-086931	Oryzias latipes	32.82	1.00e-48	187.00
IUUC-Oga-088443	Otolemur garnettii	34.62	1.00e-53	204.00
IUUC-Oar-089325	Ovis aries	34.10	1.00e-52	200.00
IUUC-Ptr-091584	Pan troglodytes	33.51	1.00e-48	187.00
IUUC-Pan-092551	Papio anubis	32.49	1.00e-48	187.00
IUUC-Psi-093366	Pelodiscus sinensis	34.53	3.00e-28	119.00
IUUC-Pno-095136	Phaeosphaeria nodorum	32.59	1.00e-42	167.00
IUUC-Ppa-095574	Physcomitrella patens	42.09	5.00e-106	377.00
IUUC-Pfo-097462	Poecilia formosa	33.42	4.00e-50	192.00
IUUC-Pab-098547	Pongo abelii	35.13	1.00e-54	207.00
IUUC-Pop-099529	Populus trichocarpa	56.86	1.00e-166	578.00
IUUC-Pca-101066	Procavia capensis	36.07	3.00e-39	156.00
IUUC-Ppe-102110	Prunus persica	74.51	2.00e-148	517.00
IUUC-Pva-103015	Pteropus vampyrus	35.13	5.00e-55	208.00
IUUC-Ptt-103998	Puccinia triticina	31.44	2.00e-40	160.00
IUUC-Pte-104417	Pyrenophora teres	33.62	5.00e-49	188.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	33.71	3.00e-49	189.00
IUUC-Rno-105533	Rattus norvegicus	36.22	2.00e-59	223.00
IUUC-Sce-106160	Saccharomyces cerevisiae	24.89	3.00e-28	120.00
IUUC-Sha-106590	Sarcophilus harrisii	33.93	1.00e-49	191.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	32.56	9.00e-45	174.00
IUUC-Spo-108353	Schizosaccharomyces pombe	32.17	2.00e-44	173.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	33.42	8.00e-46	178.00
IUUC-Smo-109645	Selaginella moellendorffii	44.19	2.00e-52	198.00
IUUC-Sit-110781	Setaria italica	49.40	3.00e-137	481.00
IUUC-Sly-111797	Solanum lycopersicum	50.27	2.00e-128	451.00
IUUC-Stu-112188	Solanum tuberosum	66.67	7.00e-139	486.00
IUUC-Sbi-114862	Sorghum bicolor	61.97	3.00e-101	362.00
IUUC-Sre-115162	Sporisorium reilianum	38.22	5.00e-30	125.00
IUUC-Ssc-115505	Sus scrofa	34.95	5.00e-42	163.00
IUUC-Tgu-116535	Taeniopygia guttata	34.01	1.00e-54	207.00
IUUC-Tru-117542	Takifugu rubripes	33.16	1.00e-54	207.00
IUUC-Tni-120200	Tetraodon nigroviridis	32.99	1.00e-53	204.00
IUUC-Tca-121548	Theobroma cacao	53.88	7.00e-134	470.00
IUUC-Tre-122124	Trichoderma reesei	33.88	2.00e-49	190.00
IUUC-Tvi-122457	Trichoderma virens	31.32	2.00e-42	167.00
IUUC-Tae-125646	Triticum aestivum	63.06	2.00e-130	459.00
IUUC-Tme-127180	Tuber melanosporum	35.31	3.00e-52	199.00
IUUC-Tbe-127530	Tupaia belangeri	35.20	4.00e-36	145.00
IUUC-Ttr-128549	Tursiops truncatus	30.10	6.00e-40	158.00
IUUC-Uma-129381	Ustilago maydis	32.43	6.00e-45	175.00
IUUC-Vda-129889	Verticillium dahliae	34.07	4.00e-45	176.00
IUUC-Vpa-130100	Vicugna pacos	32.55	4.00e-41	162.00
IUUC-Vvi-131366	Vitis vinifera	54.40	3.00e-158	551.00
IUUC-Xtr-132048	Xenopus tropicalis	33.59	1.00e-54	207.00
IUUC-Xma-133593	Xiphophorus maculatus	33.67	9.00e-51	194.00
IUUC-Yli-134338	Yarrowia lipolytica	28.78	9.00e-28	118.00
IUUC-Zma-135586	Zea mays	50.26	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence