iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000008733.3	ENSMMUT00000069798.1	ENSMMUP00000047929.1
ENSMMUG00000008733.3	ENSMMUT00000041464.2	ENSMMUP00000034493.2
ENSMMUG00000008733.3	ENSMMUT00000041465.2	ENSMMUP00000034494.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-105	353.2	746	1083

Active Site

Position(s)	Description	Evidence
1051	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ + +    ++++flGr+lgkal++
   Q: 746  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD-SFARHYYFLGRMLGKALYE 831
           689**********99**9************************************9999999999965.999**************** PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e+d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 832  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EDDVEELGLNFTV--VNNDLGEAQVVELKFGGKDIPVTSAN 915
           ******************9666889********************.6788887666665..5889********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 916  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEG 1002
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1003 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1083
           ****************************88.*****99999**************************************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQYSIQR SAFDRCATLS QSGGTFPIAN GPNLTLLVRQ LLFFYKQNED SKRLIWLYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCAGCG GCCGGAGCAG TGGCCGGCGT GGATGAGGGG CAGGCGAGGC AGGGCCGCCC 60
CTCCAGTGTT GCCGCCCCTC CCGCCCCAGG GCAGGGCTGG GAGGGTACAG CCCGGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

mcc:719956

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	93.76	0.00e+00	1957.00
IUUC-Apl-003731	Anas platyrhynchos	90.60	0.00e+00	1936.00
IUUC-Aca-005248	Anolis carolinensis	89.10	0.00e+00	1921.00
IUUC-Aly-005768	Arabidopsis lyrata	35.13	1.00e-107	384.00
IUUC-Ath-006576	Arabidopsis thaliana	34.98	2.00e-107	384.00
IUUC-Ago-007748	Ashbya gossypii	41.84	1.00e-76	281.00
IUUC-Acl-008158	Aspergillus clavatus	37.95	7.00e-76	279.00
IUUC-Afl-008398	Aspergillus flavus	33.68	2.00e-77	284.00
IUUC-Afu-008937	Aspergillus fumigatus	38.43	3.00e-78	287.00
IUUC-Ani-009252	Aspergillus nidulans	37.95	9.00e-80	292.00
IUUC-Ang-009773	Aspergillus niger	33.68	8.00e-78	285.00
IUUC-Aor-009940	Aspergillus oryzae	33.68	2.00e-77	284.00
IUUC-Ate-010395	Aspergillus terreus	38.59	4.00e-76	280.00
IUUC-Ame-010769	Astyanax mexicanus	62.83	0.00e+00	1050.00
IUUC-Bgr-012269	Blumeria graminis	37.55	3.00e-74	272.00
IUUC-Bta-012841	Bos taurus	93.00	0.00e+00	1972.00
IUUC-Bci-013743	Botrytis cinerea	29.98	2.00e-85	311.00
IUUC-Bol-015390	Brassica oleracea	45.63	7.00e-100	358.00
IUUC-Bra-016853	Brassica rapa	35.12	9.00e-107	381.00
IUUC-Cel-018638	Caenorhabditis elegans	40.34	6.00e-91	328.00
IUUC-Cja-019743	Callithrix jacchus	96.47	0.00e+00	1999.00
IUUC-Cfa-021031	Canis familiaris	95.13	0.00e+00	2008.00
IUUC-Cpo-022401	Cavia porcellus	93.26	0.00e+00	1978.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	43.99	3.00e-84	305.00
IUUC-Csa-024107	Chlorocebus sabaeus	99.72	0.00e+00	2085.00
IUUC-Cho-024750	Choloepus hoffmanni	82.92	0.00e+00	805.00
IUUC-Cin-025432	Ciona intestinalis	44.88	5.00e-97	347.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	34.26	5.00e-88	319.00
IUUC-Cne-026841	Cryptococcus neoformans	36.48	1.00e-93	338.00
IUUC-Cme-027265	Cyanidioschyzon merolae	46.86	9.00e-103	368.00
IUUC-Dre-028196	Danio rerio	76.92	0.00e+00	1600.00
IUUC-Dno-029024	Dasypus novemcinctus	95.85	0.00e+00	2031.00
IUUC-Dor-030483	Dipodomys ordii	91.64	0.00e+00	691.00
IUUC-Dse-031416	Dothistroma septosporum	34.08	9.00e-79	288.00
IUUC-Dme-031946	Drosophila melanogaster	36.73	0.00e+00	671.00
IUUC-Ete-032240	Echinops telfairi	85.06	1.00e-176	613.00
IUUC-Eca-033828	Equus caballus	95.39	0.00e+00	1991.00
IUUC-Eeu-034604	Erinaceus europaeus	85.77	2.00e-127	449.00
IUUC-Fca-035907	Felis catus	94.28	0.00e+00	2010.00
IUUC-Fal-037389	Ficedula albicollis	90.59	0.00e+00	1957.00
IUUC-Fox-037788	Fusarium oxysporum	37.07	5.00e-91	329.00
IUUC-Fso-038088	Fusarium solani	35.83	2.00e-88	321.00
IUUC-Gmo-039254	Gadus morhua	66.43	0.00e+00	1236.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.15	1.00e-83	305.00
IUUC-Gga-040310	Gallus gallus	90.50	0.00e+00	1952.00
IUUC-Gac-042054	Gasterosteus aculeatus	69.30	0.00e+00	1302.00
IUUC-Gma-042836	Glycine max	35.53	9.00e-102	365.00
IUUC-Ggo-045031	Gorilla gorilla	99.54	0.00e+00	2081.00
IUUC-Hsa-045880	Homo sapiens	99.63	0.00e+00	2081.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	90.28	0.00e+00	714.00
IUUC-Kpa-049307	Komagataella pastoris	36.75	8.00e-65	242.00
IUUC-Lch-050403	Latimeria chalumnae	81.93	0.00e+00	1690.00
IUUC-Loc-052218	Lepisosteus oculatus	80.92	0.00e+00	1703.00
IUUC-Lma-053096	Leptosphaeria maculans	38.15	1.00e-79	291.00
IUUC-Laf-054162	Loxodonta africana	91.11	0.00e+00	1711.00
IUUC-Meu-056187	Macropus eugenii	82.17	6.00e-105	375.00
IUUC-Mor-057021	Magnaporthe oryzae	35.37	3.00e-80	293.00
IUUC-Mpo-057570	Magnaporthe poae	36.46	3.00e-76	280.00
IUUC-Mtr-058154	Medicago truncatula	35.13	2.00e-104	374.00
IUUC-Mla-059124	Melampsora laricipopulina	48.28	2.00e-101	362.00
IUUC-Mga-059581	Meleagris gallopavo	90.54	0.00e+00	1942.00
IUUC-Mvi-060445	Microbotryum violaceum	37.87	2.00e-104	374.00
IUUC-Mmr-061360	Microcebus murinus	92.43	0.00e+00	1897.00
IUUC-Mdo-062194	Monodelphis domestica	87.50	0.00e+00	1943.00
IUUC-Mmu-064189	Mus musculus	93.17	0.00e+00	2009.00
IUUC-Mac-065275	Musa acuminata	48.90	1.00e-107	384.00
IUUC-Mpu-066439	Mustela putorius furo	93.07	0.00e+00	1937.00
IUUC-Mlu-068228	Myotis lucifugus	89.57	0.00e+00	1915.00
IUUC-Nfi-068280	Neosartorya fischeri	38.43	2.00e-78	287.00
IUUC-Ncr-068869	Neurospora crassa	35.61	4.00e-81	296.00
IUUC-Nle-069687	Nomascus leucogenys	98.96	0.00e+00	2021.00
IUUC-Opr-070592	Ochotona princeps	78.25	4.00e-127	449.00
IUUC-Ont-071836	Oreochromis niloticus	77.75	0.00e+00	1652.00
IUUC-Oan-072800	Ornithorhynchus anatinus	91.24	0.00e+00	1958.00
IUUC-Ocu-074587	Oryctolagus cuniculus	97.41	0.00e+00	2058.00
IUUC-Ola-087209	Oryzias latipes	77.84	0.00e+00	1630.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.59	3.00e-86	311.00
IUUC-Oga-088776	Otolemur garnettii	90.86	0.00e+00	1841.00
IUUC-Oar-089441	Ovis aries	91.90	0.00e+00	1947.00
IUUC-Ptr-091273	Pan troglodytes	99.63	0.00e+00	2081.00
IUUC-Pan-091981	Papio anubis	99.72	0.00e+00	2086.00
IUUC-Psi-093203	Pelodiscus sinensis	89.22	0.00e+00	1681.00
IUUC-Pma-094738	Petromyzon marinus	64.87	0.00e+00	1326.00
IUUC-Pno-095132	Phaeosphaeria nodorum	29.38	2.00e-59	224.00
IUUC-Ppa-095682	Physcomitrella patens	37.18	6.00e-111	395.00
IUUC-Pfo-097511	Poecilia formosa	77.93	0.00e+00	1667.00
IUUC-Pab-098634	Pongo abelii	96.49	0.00e+00	1998.00
IUUC-Pop-098928	Populus trichocarpa	34.53	2.00e-98	353.00
IUUC-Pca-100987	Procavia capensis	85.74	0.00e+00	862.00
IUUC-Pva-103034	Pteropus vampyrus	89.08	0.00e+00	1827.00
IUUC-Pgr-103513	Puccinia graminis	39.18	5.00e-106	379.00
IUUC-Ptt-103967	Puccinia triticina	41.32	8.00e-94	338.00
IUUC-Pte-104105	Pyrenophora teres	34.20	1.00e-80	295.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.28	1.00e-77	285.00
IUUC-Rno-105380	Rattus norvegicus	92.52	0.00e+00	1741.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.53	2.00e-68	254.00
IUUC-Sha-107108	Sarcophilus harrisii	84.25	0.00e+00	1786.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	42.49	6.00e-94	338.00
IUUC-Spo-108097	Schizosaccharomyces pombe	43.87	4.00e-93	336.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	30.75	5.00e-83	303.00
IUUC-Sar-113687	Sorex araneus	82.13	0.00e+00	913.00
IUUC-Sre-115038	Sporisorium reilianum	44.23	3.00e-97	350.00
IUUC-Ssc-116168	Sus scrofa	87.63	0.00e+00	810.00
IUUC-Tgu-116729	Taeniopygia guttata	90.51	0.00e+00	1954.00
IUUC-Tru-118068	Takifugu rubripes	76.64	0.00e+00	1612.00
IUUC-Tsy-118942	Tarsius syrichta	97.58	0.00e+00	727.00
IUUC-Tni-120732	Tetraodon nigroviridis	75.80	0.00e+00	1559.00
IUUC-Tre-121892	Trichoderma reesei	36.94	3.00e-87	317.00
IUUC-Tvi-122354	Trichoderma virens	35.51	1.00e-88	321.00
IUUC-Tme-127102	Tuber melanosporum	35.64	1.00e-90	328.00
IUUC-Tbe-127351	Tupaia belangeri	82.54	0.00e+00	1550.00
IUUC-Ttr-129061	Tursiops truncatus	91.24	0.00e+00	1908.00
IUUC-Uma-129343	Ustilago maydis	44.23	6.00e-98	352.00
IUUC-Vda-129748	Verticillium dahliae	38.60	4.00e-81	296.00
IUUC-Vvi-131234	Vitis vinifera	34.75	3.00e-102	367.00
IUUC-Xtr-132094	Xenopus tropicalis	85.73	0.00e+00	1795.00
IUUC-Xma-133923	Xiphophorus maculatus	78.12	0.00e+00	1669.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence