iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072101

Ensembl Protein ID

ENSONIP00000002377.1

UniProt Accession

I3J0I7; I3J0I7_ORENI

Genbank Protein ID

ENSONIP00000002377

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01025993

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000001899.1	ENSONIT00000002377.1	ENSONIP00000002376.1
ENSONIG00000001899.1	ENSONIT00000002378.1	ENSONIP00000002377.1
ENSONIG00000001899.1	ENSONIT00000002379.1	ENSONIP00000002378.1
ENSONIG00000001899.1	ENSONIT00000002380.1	ENSONIP00000002379.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-118	396.8	2110	2580

Active Site

Position(s)	Description	Evidence
2549	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2110 HADQKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQKTSLGIWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglfpapfpqdsee 2195
           689*****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+s++f+kll                                                  
   Q: 2196 leRITKLFYFLGIFLAKCIQDNRLVDLPISQPFFKLLcmgdiksnmskllyqsrsspqghdperphlqpflllsevqseasteesqe 2282
           ******************************************************999999999999999999999999999999888 PP
   S: 101  ...........................lgkklsledleevdpelykslkeikena.......es....................... 130
                                       +  l+++d++ ++p+++ +lke+k++a        s                       
   Q: 2283 tysvgsfdedsksefimdppkpkppawYHGILTWDDFQLINPHRASFLKEVKDLAvkrrqilASkslsedekntrlqdlmlknplgs 2369
           8888888887777777666666666655557***********************97666655005566677788999999999999* PP
   S: 131  ....dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteee 213
               ++e+lgl+++f++s+++ g  +++ Lkp+G++++V +eN+eeYv+l++++++++gi++q+eafreGfn+v+p+e+ls+F+++e
   Q: 2370 gpplSVEDLGLNFQFCPSSKVHGFSAVD-LKPNGDDEMVSMENAEEYVELMFDFCMHTGIQKQMEAFREGFNRVFPMEKLSSFSHKE 2455
           ******************9988888777.********************************************************** PP
   S: 214  lellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddr 297
           +++++cG+  ++++++d+ + t+ k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d++
   Q: 2456 VQMILCGNqsPSWTADDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDSS 2542
           ********6666777777777777*************************************************************** PP
   S: 298  lPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +Ps+nTC++yLkLPeYss++i++e+Ll+A++e kgF+l+
   Q: 2543 YPSVNTCVHYLKLPEYSSEDIMRERLLAATME-KGFHLN 2580
           ********************************.****86 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGAATAAT TAAAAATATT AATGATAAAA TGAAGCGAAT AGCTTTTGAA CATTGGCATT 60
TCCGAGGCAG ATGGCGACCT CTGAAGGCAG CGGGCTCAAT CGCCTCAGCT CTCCATTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	92.96	0.00e+00	2463.00
IUUC-Apl-003493	Anas platyrhynchos	81.74	0.00e+00	3902.00
IUUC-Aca-004521	Anolis carolinensis	82.34	0.00e+00	3892.00
IUUC-Ame-011258	Astyanax mexicanus	92.81	0.00e+00	2432.00
IUUC-Bta-012835	Bos taurus	81.65	0.00e+00	3896.00
IUUC-Cel-018153	Caenorhabditis elegans	51.93	8.00e-168	586.00
IUUC-Cja-019174	Callithrix jacchus	80.94	0.00e+00	3821.00
IUUC-Cfa-021115	Canis familiaris	81.68	0.00e+00	3848.00
IUUC-Cpo-022382	Cavia porcellus	77.96	0.00e+00	3645.00
IUUC-Csa-023230	Chlorocebus sabaeus	81.80	0.00e+00	3894.00
IUUC-Cho-024711	Choloepus hoffmanni	75.80	0.00e+00	1311.00
IUUC-Cin-025342	Ciona intestinalis	52.77	0.00e+00	1358.00
IUUC-Csv-026031	Ciona savignyi	51.66	0.00e+00	1386.00
IUUC-Dre-027435	Danio rerio	96.30	0.00e+00	2542.00
IUUC-Dno-029954	Dasypus novemcinctus	81.68	0.00e+00	3866.00
IUUC-Dor-030734	Dipodomys ordii	89.57	0.00e+00	1358.00
IUUC-Dme-031739	Drosophila melanogaster	58.52	0.00e+00	1615.00
IUUC-Ete-033192	Echinops telfairi	85.45	0.00e+00	1131.00
IUUC-Eca-033434	Equus caballus	81.31	0.00e+00	3860.00
IUUC-Eeu-035031	Erinaceus europaeus	77.85	0.00e+00	1022.00
IUUC-Fca-035998	Felis catus	80.26	0.00e+00	3790.00
IUUC-Fal-037468	Ficedula albicollis	81.95	0.00e+00	3856.00
IUUC-Gmo-038495	Gadus morhua	93.43	0.00e+00	1388.00
IUUC-Gga-040736	Gallus gallus	82.95	0.00e+00	3870.00
IUUC-Gac-041777	Gasterosteus aculeatus	97.02	0.00e+00	2499.00
IUUC-Ggo-044677	Gorilla gorilla	77.79	0.00e+00	3629.00
IUUC-Hsa-045879	Homo sapiens	81.80	0.00e+00	3894.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	81.68	0.00e+00	3893.00
IUUC-Lch-050444	Latimeria chalumnae	92.77	0.00e+00	2392.00
IUUC-Loc-051986	Lepisosteus oculatus	83.61	0.00e+00	3988.00
IUUC-Laf-054230	Loxodonta africana	81.36	0.00e+00	3830.00
IUUC-Mcc-054787	Macaca mulatta	81.80	0.00e+00	3894.00
IUUC-Meu-056502	Macropus eugenii	73.00	0.00e+00	1083.00
IUUC-Mga-059409	Meleagris gallopavo	93.83	0.00e+00	1880.00
IUUC-Mmr-061667	Microcebus murinus	81.05	0.00e+00	3861.00
IUUC-Mdo-061960	Monodelphis domestica	81.77	0.00e+00	3880.00
IUUC-Mmu-063941	Mus musculus	91.97	0.00e+00	2429.00
IUUC-Mpu-065939	Mustela putorius furo	81.91	0.00e+00	3896.00
IUUC-Mlu-068112	Myotis lucifugus	81.20	0.00e+00	3858.00
IUUC-Nle-069001	Nomascus leucogenys	81.80	0.00e+00	3894.00
IUUC-Opr-071222	Ochotona princeps	89.53	0.00e+00	2020.00
IUUC-Oan-072814	Ornithorhynchus anatinus	82.02	0.00e+00	3875.00
IUUC-Ocu-074011	Oryctolagus cuniculus	81.76	0.00e+00	3890.00
IUUC-Ola-086412	Oryzias latipes	90.66	0.00e+00	4115.00
IUUC-Oar-089668	Ovis aries	81.65	0.00e+00	3888.00
IUUC-Ptr-090517	Pan troglodytes	81.48	0.00e+00	3850.00
IUUC-Pan-091849	Papio anubis	89.18	0.00e+00	2333.00
IUUC-Psi-093390	Pelodiscus sinensis	80.78	0.00e+00	3774.00
IUUC-Pma-094628	Petromyzon marinus	82.36	0.00e+00	1542.00
IUUC-Ppa-095264	Physcomitrella patens	32.61	2.00e-80	294.00
IUUC-Pfo-097075	Poecilia formosa	90.80	0.00e+00	4231.00
IUUC-Pab-098176	Pongo abelii	81.80	0.00e+00	3894.00
IUUC-Pca-101123	Procavia capensis	68.83	0.00e+00	1799.00
IUUC-Pva-103008	Pteropus vampyrus	94.18	0.00e+00	1529.00
IUUC-Rno-105885	Rattus norvegicus	92.74	0.00e+00	2461.00
IUUC-Sha-107048	Sarcophilus harrisii	81.56	0.00e+00	3875.00
IUUC-Sar-113071	Sorex araneus	88.60	0.00e+00	1222.00
IUUC-Ssc-115963	Sus scrofa	92.96	0.00e+00	2464.00
IUUC-Tgu-117167	Taeniopygia guttata	74.78	0.00e+00	2095.00
IUUC-Tru-118626	Takifugu rubripes	91.58	0.00e+00	4291.00
IUUC-Tsy-119504	Tarsius syrichta	88.71	0.00e+00	1909.00
IUUC-Tni-119877	Tetraodon nigroviridis	89.59	0.00e+00	4205.00
IUUC-Tbe-127602	Tupaia belangeri	86.33	0.00e+00	1006.00
IUUC-Ttr-128394	Tursiops truncatus	75.43	0.00e+00	1453.00
IUUC-Vpa-130280	Vicugna pacos	92.52	0.00e+00	2446.00
IUUC-Xtr-131787	Xenopus tropicalis	87.21	0.00e+00	2352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence