iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054433

UUCD1 version

UUC-LoA-00070

Ensembl Protein ID

ENSLAFP00000001926.3

UniProt Accession

G3SQ72; G3SQ72_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002305.3	ENSLAFT00000002306.3	ENSLAFP00000001926.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-87	293.6	713	1032

Active Site

Position(s)	Description	Evidence
1002	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +dl+k+l +ef +E    +gGv++ef++++++e+ +p++g+f+y e++ ++++p++ ++    e+ ++F ++G+l+g++ ++ ++ +
   Q: 713  NDLSKELVIEFIEEITSVAGGVKSEFFHCVFEEMTKPEYGMFMYPEDGAYMWFPAKPKF----EKNRYF-LFGILCGLSFFHLNVAN 794
           68999*****************************************************9....567899.55*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           +p++ +++k+llg+k sledl+e+ p + k+l+e+++ + +d+ee  l + fs    i+ + +  +L+p+G +ipV ++Nk++Y ++
   Q: 795  IPFPLALFKKLLGQKPSLEDLKELSPLFEKNLQEVLNDEADDLEE--LYIFFS----IYWDKNRADLIPNGISIPVDQTNKNDYASK 875
           ************************************997666666..466665....789999999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
            v+y++++++ke +e+f++Gf++v+++e++++F++eel   i G++++d+ed++k+++y++gy +++p+iq+Fw+++++++ +e+++
   Q: 876  CVDYIFNTSVKEVYEEFQRGFYRVCDKEIIQYFQPEELMSAIVGNTDYDWEDFEKNATYDQGYYKSHPTIQMFWKAFHKLTLDEKRK 962
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL F+Tgs+rl ++G++++   +f +++  s+++ P+s TC+n L+LP+Ys++e ++e L++Ai++++gF+
   Q: 963  FLFFLTGSDRLHVKGIRNIG-IVFRCPETFSENDGPRSLTCYNILDLPKYSTMERVEEALQIAINNCRGFG 1032
           ********************.77888889*****************************************7 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

ARSGMYFCWD AGSRGRQSRE AAGGAELRQA ASGERHSLLL LSDGTVHACG DNSCGQLGRR 60
GVPHRKRPGL IQALETLNVD LLSCGKEHSL AVCHKGRVFA WGAGSEGQLG IGEFKELNFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGAGCG GGATGTACTT CTGCTGGGAC GCGGGCTCCA GGGGTCGGCA GAGCCGGGAG 60
GCGGCTGGGG GCGCCGAGCT GCGGCAGGCG GCCTCCGGGG AGCGCCACTC GCTGCTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	69.41	0.00e+00	1365.00
IUUC-Aca-004663	Anolis carolinensis	47.08	0.00e+00	880.00
IUUC-Bta-013080	Bos taurus	68.77	0.00e+00	1380.00
IUUC-Cja-018891	Callithrix jacchus	68.38	0.00e+00	1402.00
IUUC-Cfa-020763	Canis familiaris	69.24	0.00e+00	1343.00
IUUC-Cpo-022346	Cavia porcellus	65.23	0.00e+00	1387.00
IUUC-Csa-023049	Chlorocebus sabaeus	71.56	0.00e+00	1516.00
IUUC-Cho-024715	Choloepus hoffmanni	54.56	1.00e-163	570.00
IUUC-Dno-029093	Dasypus novemcinctus	71.31	0.00e+00	1470.00
IUUC-Eca-034098	Equus caballus	71.09	0.00e+00	1389.00
IUUC-Eeu-035028	Erinaceus europaeus	58.85	2.00e-167	583.00
IUUC-Fca-036283	Felis catus	71.01	0.00e+00	1418.00
IUUC-Ggo-045553	Gorilla gorilla	69.16	0.00e+00	1410.00
IUUC-Hsa-046396	Homo sapiens	71.95	0.00e+00	1487.00
IUUC-Loc-052700	Lepisosteus oculatus	40.49	0.00e+00	762.00
IUUC-Mcc-055014	Macaca mulatta	68.30	0.00e+00	1445.00
IUUC-Mdo-061839	Monodelphis domestica	53.18	0.00e+00	1001.00
IUUC-Mmu-064378	Mus musculus	61.72	0.00e+00	1249.00
IUUC-Mpu-066293	Mustela putorius furo	66.44	0.00e+00	1276.00
IUUC-Mlu-067407	Myotis lucifugus	68.38	0.00e+00	1396.00
IUUC-Nle-069978	Nomascus leucogenys	72.04	0.00e+00	1526.00
IUUC-Opr-070190	Ochotona princeps	55.34	0.00e+00	676.00
IUUC-Oga-088780	Otolemur garnettii	66.22	0.00e+00	1354.00
IUUC-Oar-090307	Ovis aries	70.71	0.00e+00	1417.00
IUUC-Ptr-091567	Pan troglodytes	72.14	0.00e+00	1491.00
IUUC-Pan-091802	Papio anubis	67.30	0.00e+00	1411.00
IUUC-Pab-098024	Pongo abelii	57.44	0.00e+00	1095.00
IUUC-Pca-100315	Procavia capensis	62.28	0.00e+00	916.00
IUUC-Pva-102382	Pteropus vampyrus	68.05	0.00e+00	1355.00
IUUC-Rno-105768	Rattus norvegicus	61.71	0.00e+00	1255.00
IUUC-Sha-106525	Sarcophilus harrisii	51.96	0.00e+00	1082.00
IUUC-Sar-113014	Sorex araneus	61.23	4.00e-163	568.00
IUUC-Vpa-130214	Vicugna pacos	67.96	0.00e+00	1243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence