iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098654

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01115730

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000018724.2	ENSPPYT00000021842.2	ENSPPYP00000021002.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-135	450.5	440	772

Active Site

Position(s)	Description	Evidence
741	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 440  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 527
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 528  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 613
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 614  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 701
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 702  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 772
           *********************************************************************96 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI RKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGKATID LKQALLIHNR KFNGESSSFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTACTCTT GCAATGTGTT CGAGGTCAAA CACTCAGCTA GGTCAGGGAG TATTTATGGA 60
CAGCCTACTT TTGCCCCCGG ACCTTAAGAA GTCCTGCTCC GGGATCAGCC GCCGACTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	92.54	0.00e+00	1289.00
IUUC-Apl-003310	Anas platyrhynchos	83.36	0.00e+00	1141.00
IUUC-Aca-005388	Anolis carolinensis	82.53	0.00e+00	1134.00
IUUC-Bta-012857	Bos taurus	92.69	0.00e+00	1272.00
IUUC-Cja-019448	Callithrix jacchus	95.88	0.00e+00	1341.00
IUUC-Cfa-020728	Canis familiaris	93.42	0.00e+00	1313.00
IUUC-Cpo-021635	Cavia porcellus	87.72	0.00e+00	1229.00
IUUC-Csa-023805	Chlorocebus sabaeus	96.48	0.00e+00	1337.00
IUUC-Cho-024943	Choloepus hoffmanni	81.43	0.00e+00	1083.00
IUUC-Cin-025212	Ciona intestinalis	72.84	0.00e+00	899.00
IUUC-Csv-026256	Ciona savignyi	71.45	0.00e+00	881.00
IUUC-Dre-028245	Danio rerio	88.66	0.00e+00	1100.00
IUUC-Dno-029618	Dasypus novemcinctus	93.97	0.00e+00	1293.00
IUUC-Dme-032041	Drosophila melanogaster	70.02	0.00e+00	875.00
IUUC-Ete-032779	Echinops telfairi	91.90	0.00e+00	1063.00
IUUC-Eca-033313	Equus caballus	92.15	0.00e+00	1223.00
IUUC-Eeu-035259	Erinaceus europaeus	82.16	0.00e+00	1119.00
IUUC-Fca-035420	Felis catus	94.26	0.00e+00	1315.00
IUUC-Fal-037335	Ficedula albicollis	83.21	0.00e+00	1148.00
IUUC-Gmo-039172	Gadus morhua	83.98	0.00e+00	1001.00
IUUC-Gga-040246	Gallus gallus	84.16	0.00e+00	1152.00
IUUC-Gac-042211	Gasterosteus aculeatus	88.72	0.00e+00	1112.00
IUUC-Ggo-045001	Gorilla gorilla	84.53	0.00e+00	1377.00
IUUC-Hsa-046544	Homo sapiens	96.62	0.00e+00	1353.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	90.98	0.00e+00	1279.00
IUUC-Lch-050398	Latimeria chalumnae	90.50	0.00e+00	1117.00
IUUC-Loc-052116	Lepisosteus oculatus	91.13	0.00e+00	1130.00
IUUC-Laf-053551	Loxodonta africana	91.76	0.00e+00	1237.00
IUUC-Meu-056455	Macropus eugenii	74.41	0.00e+00	630.00
IUUC-Mga-059986	Meleagris gallopavo	82.85	0.00e+00	1154.00
IUUC-Mmr-060945	Microcebus murinus	90.22	0.00e+00	1250.00
IUUC-Mdo-063024	Monodelphis domestica	82.14	0.00e+00	1083.00
IUUC-Mmu-063202	Mus musculus	90.29	0.00e+00	1223.00
IUUC-Mpu-065773	Mustela putorius furo	93.00	0.00e+00	1303.00
IUUC-Nle-069188	Nomascus leucogenys	97.06	0.00e+00	1357.00
IUUC-Opr-070965	Ochotona princeps	90.78	0.00e+00	1207.00
IUUC-Ont-072226	Oreochromis niloticus	89.23	0.00e+00	1117.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.90	0.00e+00	1147.00
IUUC-Ocu-073891	Oryctolagus cuniculus	87.01	0.00e+00	1180.00
IUUC-Ola-087438	Oryzias latipes	86.80	0.00e+00	1116.00
IUUC-Oga-087922	Otolemur garnettii	93.44	0.00e+00	1314.00
IUUC-Oar-089429	Ovis aries	92.54	0.00e+00	1259.00
IUUC-Ptr-090484	Pan troglodytes	96.62	0.00e+00	1353.00
IUUC-Pan-092117	Papio anubis	96.76	0.00e+00	1355.00
IUUC-Psi-093338	Pelodiscus sinensis	83.65	0.00e+00	1150.00
IUUC-Pma-094279	Petromyzon marinus	73.16	0.00e+00	813.00
IUUC-Pfo-096171	Poecilia formosa	90.07	0.00e+00	1119.00
IUUC-Pva-102811	Pteropus vampyrus	89.68	0.00e+00	1164.00
IUUC-Rno-106125	Rattus norvegicus	90.29	0.00e+00	1235.00
IUUC-Sha-107243	Sarcophilus harrisii	84.62	0.00e+00	1150.00
IUUC-Ssc-115368	Sus scrofa	92.09	0.00e+00	1256.00
IUUC-Tgu-117079	Taeniopygia guttata	83.19	0.00e+00	1138.00
IUUC-Tru-118062	Takifugu rubripes	87.83	0.00e+00	1122.00
IUUC-Tsy-119507	Tarsius syrichta	88.24	0.00e+00	1206.00
IUUC-Tni-120151	Tetraodon nigroviridis	88.93	0.00e+00	1104.00
IUUC-Ttr-129260	Tursiops truncatus	79.24	0.00e+00	1042.00
IUUC-Xtr-132877	Xenopus tropicalis	77.56	0.00e+00	918.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence