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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064225
UUCD1 version UUC-MuM-00038
Ensembl Protein ID ENSMUSP00000100869.3
UniProt Accession Q8BH75; Q8BGJ2; Q8BMC9; Q8VEA2; Q9CRK6; Q9D568; RNF41_MOUSE
Genbank Protein ID BAB29953.1; BAB32125.1; BAC26004.1; BAC27020.1; BAC27496.1; BAC28054.1; BAC28750.1; BAC31779.1; BAC36813.1; AAH19415.1; AAH49078.1
Protein Name E3 ubiquitin-protein ligase NRDP1; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1
Genbank Nucleotide ID AK015745; AK020527; AK028551; AK030558; AK031657; AK032848; AK034551; AK044103; AK077466; BC019415; BC049078
Gene Name Rnf41; Flrf; Nrdp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025373.13 ENSMUST00000096386.11 ENSMUSP00000100869.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18986647; 14765125; 20628057
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.40e-06 28.6 12 69
E3 activity/RING/RING 6.70e-06 27.6 18 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99998887764 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
 Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).
Protein Sequence
(Fasta)
MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064225|E3,RING;E3,U-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGCTTCCGC CCCGTTGCGT AGCAGCAGTG GGCGTGGCTA AGGGCTAACC CGAGACAGCG 60
AGGAGTGGTC GGAACCTTCT TCCCCATCCT TACCTTCCCC TTCCCCTACG GGGAAAGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064225|E3,RING;E3,U-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR013010--Znf_SIAH
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS51081--ZF_SIAH
Pfam

PF08941--USP8_interact
SMART

SM00184--RING
Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0005128--F:erythropoietin receptor binding
GO:0005135--F:interleukin-3 receptor binding
GO:0031386--F:protein tag
GO:0017160--F:Ral GTPase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0010468--P:regulation of gene expression
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling
GO:2000377--P:regulation of reactive oxygen species metabolic process
KEGG mmu:67588
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002398 Ailuropoda melanoleuca 99.37 0.00e+00 658.00
IUUC-Apl-003568 Anas platyrhynchos 95.91 0.00e+00 631.00
IUUC-Aca-005119 Anolis carolinensis 96.53 0.00e+00 644.00
IUUC-Ame-010708 Astyanax mexicanus 90.85 8.00e-179 619.00
IUUC-Bta-013428 Bos taurus 94.01 4.00e-179 620.00
IUUC-Cja-019844 Callithrix jacchus 99.37 0.00e+00 655.00
IUUC-Cfa-021124 Canis familiaris 99.68 0.00e+00 659.00
IUUC-Cpo-022325 Cavia porcellus 99.37 0.00e+00 658.00
IUUC-Csa-023113 Chlorocebus sabaeus 99.68 0.00e+00 659.00
IUUC-Cho-024991 Choloepus hoffmanni 98.97 5.00e-114 402.00
IUUC-Cne-026870 Cryptococcus neoformans 38.52 4.00e-20 93.20
IUUC-Dre-028730 Danio rerio 90.54 2.00e-178 617.00
IUUC-Dno-028908 Dasypus novemcinctus 99.30 1.00e-171 594.00
IUUC-Dor-030411 Dipodomys ordii 99.37 0.00e+00 659.00
IUUC-Dme-031868 Drosophila melanogaster 57.46 5.00e-111 393.00
IUUC-Ete-032896 Echinops telfairi 81.51 4.00e-125 440.00
IUUC-Eca-034135 Equus caballus 99.68 0.00e+00 659.00
IUUC-Eeu-034675 Erinaceus europaeus 99.37 0.00e+00 657.00
IUUC-Fca-035612 Felis catus 99.68 0.00e+00 659.00
IUUC-Fal-036922 Ficedula albicollis 97.53 3.00e-42 162.00
IUUC-Gmo-039648 Gadus morhua 87.38 7.00e-172 595.00
IUUC-Gga-040474 Gallus gallus 96.85 0.00e+00 645.00
IUUC-Gac-041951 Gasterosteus aculeatus 88.64 9.00e-175 605.00
IUUC-Ggo-045126 Gorilla gorilla 99.37 0.00e+00 655.00
IUUC-Hsa-046402 Homo sapiens 99.68 0.00e+00 659.00
IUUC-Itr-047895 Ictidomys tridecemlineatus 99.68 0.00e+00 659.00
IUUC-Lch-050266 Latimeria chalumnae 93.38 0.00e+00 629.00
IUUC-Loc-052547 Lepisosteus oculatus 91.80 1.00e-179 622.00
IUUC-Laf-054332 Loxodonta africana 99.06 0.00e+00 654.00
IUUC-Mcc-055869 Macaca mulatta 99.68 0.00e+00 659.00
IUUC-Meu-056735 Macropus eugenii 99.65 5.00e-172 596.00
IUUC-Mla-059147 Melampsora laricipopulina 37.11 4.00e-13 68.90
IUUC-Mga-060100 Meleagris gallopavo 96.85 0.00e+00 645.00
IUUC-Mmr-061382 Microcebus murinus 99.68 0.00e+00 659.00
IUUC-Mpu-066709 Mustela putorius furo 99.68 0.00e+00 659.00
IUUC-Mlu-067168 Myotis lucifugus 98.74 0.00e+00 657.00
IUUC-Nle-070176 Nomascus leucogenys 99.68 0.00e+00 659.00
IUUC-Opr-070259 Ochotona princeps 99.37 0.00e+00 658.00
IUUC-Ont-071235 Oreochromis niloticus 89.91 4.00e-177 613.00
IUUC-Oan-072850 Ornithorhynchus anatinus 58.12 6.00e-91 327.00
IUUC-Ocu-074165 Oryctolagus cuniculus 99.37 0.00e+00 658.00
IUUC-Ola-086658 Oryzias latipes 88.33 3.00e-173 600.00
IUUC-Oga-088933 Otolemur garnettii 99.68 0.00e+00 659.00
IUUC-Oar-090089 Ovis aries 99.37 0.00e+00 659.00
IUUC-Ptr-091263 Pan troglodytes 99.68 0.00e+00 659.00
IUUC-Pan-092926 Papio anubis 99.68 0.00e+00 659.00
IUUC-Psi-093934 Pelodiscus sinensis 89.31 4.00e-168 583.00
IUUC-Pma-094578 Petromyzon marinus 68.97 4.00e-127 447.00
IUUC-Pno-094854 Phaeosphaeria nodorum 36.59 2.00e-13 70.90
IUUC-Pfo-097431 Poecilia formosa 89.91 7.00e-177 612.00
IUUC-Pab-097852 Pongo abelii 99.68 0.00e+00 659.00
IUUC-Pca-100496 Procavia capensis 91.19 9.00e-169 585.00
IUUC-Pva-103157 Pteropus vampyrus 98.50 2.00e-116 410.00
IUUC-Pgr-103416 Puccinia graminis 32.04 2.00e-13 70.50
IUUC-Rno-105928 Rattus norvegicus 99.37 0.00e+00 658.00
IUUC-Sha-107556 Sarcophilus harrisii 99.06 0.00e+00 653.00
IUUC-Sar-113208 Sorex araneus 99.68 0.00e+00 659.00
IUUC-Ssc-116011 Sus scrofa 99.37 0.00e+00 659.00
IUUC-Tgu-116882 Taeniopygia guttata 74.50 3.00e-73 267.00
IUUC-Tru-117987 Takifugu rubripes 89.59 2.00e-176 611.00
IUUC-Tsy-118785 Tarsius syrichta 99.37 0.00e+00 653.00
IUUC-Tni-120165 Tetraodon nigroviridis 89.27 6.00e-176 609.00
IUUC-Tbe-127920 Tupaia belangeri 99.00 2.00e-118 417.00
IUUC-Ttr-129160 Tursiops truncatus 99.05 0.00e+00 657.00
IUUC-Vpa-130629 Vicugna pacos 99.68 0.00e+00 659.00
IUUC-Xtr-131895 Xenopus tropicalis 95.27 0.00e+00 635.00
Created Date 25-Jun-2017

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