iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fso-038133

Ensembl Protein ID

NechaP91728

UniProt Accession

C7YLK7; C7YLK7_NECH7

Genbank Protein ID

EEU47284.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

GG698897

Gene Name

PAN2; NECHADRAFT_91728

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NechaG91728	NechaT91728	NechaP91728

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-11	44.3	527	743

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 131  eekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......slqdcLesftkeeelegenkyycekckkkqeaekklk 222
           + k  +  +s +++++  + +s+ikc +c+++++r  + +   l  p++++ +        +++++L++ +++e+     k +c++c+++q+   + +
   Q: 527  DHKSINPASSAMDQVLATSATSSIKCISCRSEYTRPGSTYVNDLLYPSNKSGARGakmpriTFSQVLKNSVERETTS---KGWCSRCQRYQTIATRKS 621
           56777888899**********************9999999888888888766544788999***************9...59**************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....p.fcts.......peekqkekkkYeLiavv..vHsGslssGHYvayvkn..... 301
           ++++P vL+l+    +     ++r+  ++   +p+e+ +     + fc +        +++ ++ + Y+Li++   + sG++++ H v++v+      
   Q: 622  IHSVPAVLMLNTAITNS----DHRILWSTPGWLPEEIGIIvehgQfFCYEgedlklhLQRGIHNITVYSLIGMAinIESGQTQKSHLVSMVNVahaet 715
           **********9987733....33445555555555544443333323333222222233344449*****9875114578*************77777 PP
   S: 302  ...ekgkWllfdDskVtevkeeevleet 326
               + +W lf+D  V++v+ ee l+++
   Q: 716  eapGESQWHLFNDFLVRSVSTEEALTFN 743
           7766788**************9999875 PP

Organism

Fusarium solani

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDGDWDEVAR IQFPPPGVHA LPTPVTTMTF DTSQELLWTG NDYGRVTSFY GTELQRYTSF 60
KAHASADGPV RQILVNEKGV VALGAKDVHM AMRRGVPMWH IKRDDMDDLR CMSFTSKGTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGTG ATTGGGATGA GGTATGTCTG CCCAACAGCG ATGCGCCCAG CCTCGGATTG 60
CAGAGACAAA CCGCCCTTTT GCGCTGGTTT TCCAGGTCGC GATAATATAT ACATCGCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

nhe:NECHADRAFT_91728

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	29.54	7.00e-128	450.00
IUUC-Apl-003500	Anas platyrhynchos	30.26	4.00e-74	271.00
IUUC-Aca-004930	Anolis carolinensis	31.77	9.00e-93	333.00
IUUC-Acl-008214	Aspergillus clavatus	45.69	0.00e+00	977.00
IUUC-Afu-009112	Aspergillus fumigatus	45.94	0.00e+00	986.00
IUUC-Ang-009531	Aspergillus niger	48.76	4.00e-177	613.00
IUUC-Ame-011259	Astyanax mexicanus	32.63	1.00e-92	333.00
IUUC-Bta-012371	Bos taurus	29.89	3.00e-129	454.00
IUUC-Bci-013684	Botrytis cinerea	50.23	0.00e+00	1064.00
IUUC-Cja-019297	Callithrix jacchus	29.24	4.00e-124	437.00
IUUC-Cfa-020489	Canis familiaris	29.80	5.00e-128	450.00
IUUC-Cpo-022392	Cavia porcellus	31.80	2.00e-95	342.00
IUUC-Csa-023220	Chlorocebus sabaeus	30.02	5.00e-127	447.00
IUUC-Cho-025098	Choloepus hoffmanni	26.55	8.00e-03	33.50
IUUC-Csv-025841	Ciona savignyi	34.02	4.00e-64	238.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	67.12	0.00e+00	1499.00
IUUC-Cne-026932	Cryptococcus neoformans	36.28	2.00e-101	362.00
IUUC-Dre-028482	Danio rerio	31.65	1.00e-92	333.00
IUUC-Dno-029398	Dasypus novemcinctus	29.86	1.00e-125	442.00
IUUC-Dor-030307	Dipodomys ordii	29.19	3.00e-80	291.00
IUUC-Dme-032111	Drosophila melanogaster	39.01	3.00e-67	248.00
IUUC-Eca-033985	Equus caballus	29.66	4.00e-129	454.00
IUUC-Eeu-034928	Erinaceus europaeus	29.73	2.00e-28	119.00
IUUC-Fca-035587	Felis catus	29.63	2.00e-130	459.00
IUUC-Fal-037587	Ficedula albicollis	32.08	8.00e-91	327.00
IUUC-Gmo-039076	Gadus morhua	42.81	9.00e-73	267.00
IUUC-Ggr-039957	Gaeumannomyces graminis	58.42	0.00e+00	760.00
IUUC-Gga-040948	Gallus gallus	32.64	2.00e-94	338.00
IUUC-Gac-042396	Gasterosteus aculeatus	43.11	1.00e-73	270.00
IUUC-Ggo-045412	Gorilla gorilla	29.45	1.00e-127	449.00
IUUC-Hsa-046076	Homo sapiens	29.36	3.00e-127	447.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	39.60	2.00e-63	236.00
IUUC-Kpa-049178	Komagataella pastoris	34.21	2.00e-92	332.00
IUUC-Lch-050279	Latimeria chalumnae	33.52	4.00e-79	288.00
IUUC-Loc-052872	Lepisosteus oculatus	42.11	4.00e-71	261.00
IUUC-Lma-052986	Leptosphaeria maculans	52.06	0.00e+00	645.00
IUUC-Laf-054181	Loxodonta africana	42.00	2.00e-77	282.00
IUUC-Mcc-054812	Macaca mulatta	29.69	2.00e-128	452.00
IUUC-Meu-056325	Macropus eugenii	32.89	1.00e-96	346.00
IUUC-Mor-057246	Magnaporthe oryzae	49.19	3.00e-169	587.00
IUUC-Mpo-057464	Magnaporthe poae	58.63	0.00e+00	773.00
IUUC-Mla-058911	Melampsora laricipopulina	36.62	2.00e-98	352.00
IUUC-Mga-059335	Meleagris gallopavo	32.71	6.00e-92	330.00
IUUC-Mvi-060461	Microbotryum violaceum	38.17	2.00e-108	385.00
IUUC-Mmr-060636	Microcebus murinus	29.66	6.00e-128	450.00
IUUC-Mmu-063503	Mus musculus	29.29	7.00e-129	453.00
IUUC-Mpu-066670	Mustela putorius furo	29.72	2.00e-129	454.00
IUUC-Mlu-068119	Myotis lucifugus	29.40	5.00e-133	467.00
IUUC-Nfi-068398	Neosartorya fischeri	48.22	2.00e-176	612.00
IUUC-Ncr-068927	Neurospora crassa	52.84	0.00e+00	673.00
IUUC-Nle-069651	Nomascus leucogenys	31.51	9.00e-96	343.00
IUUC-Opr-070614	Ochotona princeps	29.34	2.00e-122	431.00
IUUC-Ont-072433	Oreochromis niloticus	31.55	1.00e-93	336.00
IUUC-Oan-073283	Ornithorhynchus anatinus	40.51	2.00e-68	252.00
IUUC-Ocu-074401	Oryctolagus cuniculus	42.00	3.00e-75	275.00
IUUC-Ola-087522	Oryzias latipes	32.02	3.00e-94	338.00
IUUC-Oga-088226	Otolemur garnettii	42.00	3.00e-75	275.00
IUUC-Oar-089241	Ovis aries	29.75	4.00e-131	461.00
IUUC-Pan-092297	Papio anubis	29.36	9.00e-115	406.00
IUUC-Psi-094043	Pelodiscus sinensis	41.45	1.00e-65	243.00
IUUC-Pma-094394	Petromyzon marinus	42.86	6.00e-71	261.00
IUUC-Pno-095053	Phaeosphaeria nodorum	45.19	0.00e+00	826.00
IUUC-Ppa-095188	Physcomitrella patens	41.61	1.00e-60	226.00
IUUC-Pfo-097517	Poecilia formosa	32.04	1.00e-93	336.00
IUUC-Pca-100471	Procavia capensis	29.82	9.00e-128	449.00
IUUC-Pva-102805	Pteropus vampyrus	31.91	1.00e-90	326.00
IUUC-Pte-104021	Pyrenophora teres	47.61	0.00e+00	1014.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	47.33	0.00e+00	1003.00
IUUC-Rno-105471	Rattus norvegicus	32.14	1.00e-97	349.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.75	2.00e-71	262.00
IUUC-Sha-106883	Sarcophilus harrisii	43.66	2.00e-77	282.00
IUUC-Spo-108169	Schizosaccharomyces pombe	36.68	2.00e-107	382.00
IUUC-Sar-113323	Sorex araneus	31.99	8.00e-94	337.00
IUUC-Sre-115075	Sporisorium reilianum	43.40	3.00e-69	256.00
IUUC-Ssc-116363	Sus scrofa	42.29	8.00e-78	283.00
IUUC-Tru-118427	Takifugu rubripes	42.77	3.00e-75	275.00
IUUC-Tni-120218	Tetraodon nigroviridis	42.65	2.00e-76	279.00
IUUC-Tre-122177	Trichoderma reesei	66.12	0.00e+00	1447.00
IUUC-Tme-127176	Tuber melanosporum	41.58	0.00e+00	774.00
IUUC-Tbe-127641	Tupaia belangeri	25.50	8.00e-24	104.00
IUUC-Ttr-128888	Tursiops truncatus	32.84	8.00e-91	327.00
IUUC-Uma-129361	Ustilago maydis	44.38	4.00e-68	252.00
IUUC-Xtr-132811	Xenopus tropicalis	41.37	2.00e-73	269.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence