iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000019952.14	ENSMUST00000020113.14	ENSMUSP00000020113.8
ENSMUSG00000019952.14	ENSMUST00000159228.7	ENSMUSP00000124144.1
ENSMUSG00000019952.14	ENSMUST00000159043.1	ENSMUSP00000123719.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-52	173.4	143	178
UBD/Beta-Prp	8.00e-80	269.3	59	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           Ht +v+c +f +d +l+vs+s D+tik+WD++   +
   Q: 143  HTHWVRCAKFsPDgRLIVSCSEDKTIKIWDTTNKQC 178
           9**********999****************987665 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           hk+v+t+++fsp+++lla++srd+t+++w ++++ + ++++ h+a+v++v+fs dg++lvt+seD+ ikvw++     +++l +h++ v
   Q: 59   HKDVVTSLQFSPQGNLLASASRDRTVRLWVLDRKGKSSEFKAHTAPVRSVDFSADGQLLVTASEDKSIKVWSMFRQRFLYSLYRHTHWV 147
           899************************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
           ++ +fsp+g  +vs s+d+ti++wd+ ++qc++  +s   g+ n v ++p+g +++s++ D +v++Wd++++kll++ +  h   v++l
   Q: 148  RCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN-NFSDSVGFANFVDFNPNGTCIASAGSDHAVKIWDIRMNKLLQHYQV-HSCGVNCL 234
           *********************************.*********************************************8.******** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW..d 250
           sf++ g++lv++s dgtvk+ dl +g+ ++tl+ght +v  v fs+++e+l sg++D ++ iW  +
   Q: 235  SFHPLGNSLVTASSDGTVKMLDLIEGRLIYTLQGHTGPVFTVSFSKDGELLTSGGADAQVLIWrtN 300
           ***************************************************************553 PP

Organism

Mus musculus

Functional Description
(View)

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity.

Protein Sequence
(Fasta)

MASGLEDPIL ERSFKGHKAA ITSADFSPNC KQIATASWDT FLMLWSLKPH ARAYRYVGHK 60
DVVTSLQFSP QGNLLASASR DRTVRLWVLD RKGKSSEFKA HTAPVRSVDF SADGQLLVTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTCGGGGC TCGTCTGGCC ACGCCTGGAG CGCGGGCTTT GATTGGGCCG CCGTTGTTGT 60
AGTGACCGGG AAGCGCCCGC ACTCCAGTCT GACGGTTCCG GGCGCCGCAC GGTCCCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0000922--C:spindle pole
GO:0008283--P:cell proliferation
GO:0060271--P:cilium assembly
GO:0001895--P:retina homeostasis

KEGG

mmu:382406

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002219	Ailuropoda melanoleuca	81.43	0.00e+00	754.00
IUUC-Apl-004219	Anas platyrhynchos	57.66	2.00e-149	522.00
IUUC-Aca-005197	Anolis carolinensis	55.81	6.00e-160	557.00
IUUC-Ame-011000	Astyanax mexicanus	54.55	6.00e-152	530.00
IUUC-Bta-012706	Bos taurus	81.76	0.00e+00	812.00
IUUC-Cja-019185	Callithrix jacchus	77.05	0.00e+00	750.00
IUUC-Cfa-021274	Canis familiaris	82.24	0.00e+00	813.00
IUUC-Cpo-022351	Cavia porcellus	77.18	0.00e+00	782.00
IUUC-Csa-023032	Chlorocebus sabaeus	77.20	0.00e+00	751.00
IUUC-Cho-024508	Choloepus hoffmanni	71.22	1.00e-174	606.00
IUUC-Dre-028703	Danio rerio	55.34	2.00e-150	525.00
IUUC-Dno-028915	Dasypus novemcinctus	81.53	0.00e+00	769.00
IUUC-Dor-030306	Dipodomys ordii	69.59	9.00e-175	606.00
IUUC-Dme-032182	Drosophila melanogaster	43.73	8.00e-77	280.00
IUUC-Ete-032353	Echinops telfairi	66.52	1.00e-177	615.00
IUUC-Eca-034136	Equus caballus	82.02	0.00e+00	757.00
IUUC-Eeu-034611	Erinaceus europaeus	74.42	7.00e-172	596.00
IUUC-Fca-036205	Felis catus	81.19	0.00e+00	713.00
IUUC-Fal-036947	Ficedula albicollis	49.89	1.00e-127	449.00
IUUC-Gga-040847	Gallus gallus	56.51	1.00e-152	533.00
IUUC-Ggo-045194	Gorilla gorilla	82.01	0.00e+00	822.00
IUUC-Hsa-047026	Homo sapiens	82.01	0.00e+00	822.00
IUUC-Itr-048943	Ictidomys tridecemlineatus	82.06	0.00e+00	775.00
IUUC-Lch-050067	Latimeria chalumnae	57.70	2.00e-163	568.00
IUUC-Loc-052409	Lepisosteus oculatus	58.14	2.00e-157	549.00
IUUC-Laf-053428	Loxodonta africana	81.99	0.00e+00	791.00
IUUC-Mcc-054772	Macaca mulatta	82.22	0.00e+00	819.00
IUUC-Meu-056496	Macropus eugenii	68.10	7.00e-152	530.00
IUUC-Mga-059276	Meleagris gallopavo	55.91	7.00e-153	533.00
IUUC-Mmr-061525	Microcebus murinus	82.01	0.00e+00	812.00
IUUC-Mdo-062351	Monodelphis domestica	66.67	0.00e+00	677.00
IUUC-Mpu-066453	Mustela putorius furo	79.92	0.00e+00	782.00
IUUC-Mlu-067909	Myotis lucifugus	79.24	0.00e+00	737.00
IUUC-Nle-069206	Nomascus leucogenys	82.01	0.00e+00	830.00
IUUC-Opr-070566	Ochotona princeps	70.97	0.00e+00	699.00
IUUC-Oan-073726	Ornithorhynchus anatinus	62.36	2.00e-160	558.00
IUUC-Ocu-074639	Oryctolagus cuniculus	82.18	0.00e+00	833.00
IUUC-Ola-086913	Oryzias latipes	51.90	4.00e-138	484.00
IUUC-Oga-088061	Otolemur garnettii	83.24	3.00e-177	613.00
IUUC-Oar-090228	Ovis aries	77.43	0.00e+00	810.00
IUUC-Ptr-091420	Pan troglodytes	82.22	0.00e+00	824.00
IUUC-Pan-092228	Papio anubis	82.01	0.00e+00	818.00
IUUC-Psi-093309	Pelodiscus sinensis	58.82	2.00e-160	558.00
IUUC-Pab-098109	Pongo abelii	82.85	0.00e+00	828.00
IUUC-Pca-101012	Procavia capensis	61.30	2.00e-163	568.00
IUUC-Pva-102712	Pteropus vampyrus	81.13	0.00e+00	813.00
IUUC-Rno-105260	Rattus norvegicus	91.40	0.00e+00	914.00
IUUC-Sar-113446	Sorex araneus	70.29	0.00e+00	697.00
IUUC-Ssc-115794	Sus scrofa	84.45	0.00e+00	669.00
IUUC-Tgu-116770	Taeniopygia guttata	50.84	1.00e-131	463.00
IUUC-Tru-117968	Takifugu rubripes	52.51	1.00e-137	482.00
IUUC-Tsy-119316	Tarsius syrichta	69.14	1.00e-179	622.00
IUUC-Tni-119953	Tetraodon nigroviridis	48.55	5.00e-123	434.00
IUUC-Tbe-128071	Tupaia belangeri	77.65	0.00e+00	695.00
IUUC-Ttr-129267	Tursiops truncatus	80.96	0.00e+00	805.00
IUUC-Vpa-130823	Vicugna pacos	75.41	4.00e-161	560.00
IUUC-Xtr-131768	Xenopus tropicalis	56.48	4.00e-157	547.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence