iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ata-000764

Ensembl Protein ID

EMT20348

UniProt Accession

R7WDP5; R7WDP5_AEGTA

Genbank Protein ID

EMT20348.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

KD527103

Gene Name

F775_27749

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
F775_27749	EMT20348	EMT20348

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.60e-104	348.9	14	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+r+wG+++q++l++a+++l+++g++G+E lKnLvl+G+gs+tvvD+++ve+s+l+++FL+++   g+s+A++ + +l+eln+ v+++ +ees+ +  
   Q: 14   YDRQLRIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEQSDLGNNFLLDEGCLGQSRAKSICSFLQELNDAVKAKYVEESPATMI 114
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiew 189
           ++++ Ff++f+vV++++ ++++ +k++++c++a++ l+ ++++Gl G vrv+ik++ +++s++d   d++++ +P+++lk++           ++++++++
   Q: 115  DTNPsFFSQFTVVLATQLPESSLLKLDSICRSANIVLVAARSYGLTGLVRVSIKEHCVIESKPDhslDDLRLHNPWPELKQFAKsidicdkdpVVHKHTPY 215
           **99******************************************************************************99999999999******** PP
   S: 190  avlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............... 274
           +v++  l+e++a +++++ +++++ek+e+kd++++ + + de+n++ea+e + k   +  i++ i+q++++ +  +v+ s+s+fwv               
   Q: 216  IVILVRLAEKWADAHDGQLPSTRQEKREFKDLIRAHMLNVDEDNYKEAVESSYKVSVTPGISDeIRQIIDD-SSSEVNFSSSDFWVlvaslkefianegng 315
           ***********************************************************************.55599************************ PP
   S: 275  ............................................................sfcsnaealq..............vpekvekdeevvkasap 301
                                                                       +fc+n+++l+              v     + +++++++++
   Q: 316  elplegtipdmtslteyyvslqkiyqakaesdclaiehrvksilrrigrdpdsisracikTFCKNTRKLKvcryrsmeeefsspV---LSEVKKYFADEDS 413
           **********************************************************************666665555543221...2233333333333 PP
   S: 302  .....lylllralerfekkkgrkpgels...fekddds.avdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkf 392
                +y+llra++r++++++r pg ++   f  +  + +++l++aa +   +++g+++  l++dli+e+++++ ++i++++a++gG+a+qEviK+v+++f
   Q: 414  cfamnFYVLLRAVDRLAANYSRLPGIFDstgFTSEIGEdVPRLKEAAVSVL-SDMGLKGsSLSEDLIAEVCRFAGAEIHPVAAFIGGVASQEVIKLVTKQF 513
           67788*******************966511144554446777877777666.************************************************* PP
   S: 393  eplknfflfdae 404
           +pl+ +f+f+++
   Q: 514  VPLNGTFIFNGI 525
           *********986 PP

Organism

Aegilops tauschii

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAAAAAEP KTKYDRQLRI WGDQGQAALE KASICLLNCG PTGTEALKNL VLGGIGSVTV 60
VDGSKVEQSD LGNNFLLDEG CLGQSRAKSI CSFLQELNDA VKAKYVEESP ATMIDTNPSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCCG CCGCCGCCGC CGCCGAGCCC AAGACCAAGT ACGATCGCCA GCTCAGGTAA 60
CGCGTCGGCT CTCTTCCTCC CGCCCTCCCT CCAGCACACC CTCGGTCACA TCTCCGCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

ats:F775_27749

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002333	Ailuropoda melanoleuca	42.78	6.00e-127	447.00
IUUC-Atr-002644	Amborella trichopoda	69.20	0.00e+00	733.00
IUUC-Apl-003446	Anas platyrhynchos	42.69	7.00e-119	420.00
IUUC-Aca-004450	Anolis carolinensis	41.43	3.00e-123	434.00
IUUC-Aly-005466	Arabidopsis lyrata	64.52	0.00e+00	730.00
IUUC-Ath-006692	Arabidopsis thaliana	65.65	0.00e+00	734.00
IUUC-Ago-007900	Ashbya gossypii	27.76	2.00e-40	159.00
IUUC-Acl-008333	Aspergillus clavatus	33.33	1.00e-71	263.00
IUUC-Afl-008529	Aspergillus flavus	33.21	1.00e-76	280.00
IUUC-Afu-009071	Aspergillus fumigatus	32.69	5.00e-70	258.00
IUUC-Ani-009443	Aspergillus nidulans	32.42	1.00e-64	240.00
IUUC-Ang-009669	Aspergillus niger	32.79	1.00e-74	273.00
IUUC-Aor-009914	Aspergillus oryzae	32.91	8.00e-75	273.00
IUUC-Ate-010450	Aspergillus terreus	32.37	2.00e-70	259.00
IUUC-Ame-011183	Astyanax mexicanus	40.49	3.00e-120	424.00
IUUC-Bgr-012111	Blumeria graminis	32.72	1.00e-62	233.00
IUUC-Bta-012583	Bos taurus	42.91	2.00e-128	451.00
IUUC-Bci-013892	Botrytis cinerea	31.51	4.00e-60	224.00
IUUC-Bdi-014592	Brachypodium distachyon	90.87	0.00e+00	959.00
IUUC-Bol-016399	Brassica oleracea	65.97	0.00e+00	742.00
IUUC-Bra-017506	Brassica rapa	64.90	0.00e+00	724.00
IUUC-Cel-018456	Caenorhabditis elegans	30.54	2.00e-69	256.00
IUUC-Cja-020007	Callithrix jacchus	42.88	1.00e-126	446.00
IUUC-Cfa-020324	Canis familiaris	42.72	9.00e-129	452.00
IUUC-Cpo-022248	Cavia porcellus	39.31	8.00e-70	256.00
IUUC-Csa-023149	Chlorocebus sabaeus	39.66	2.00e-99	355.00
IUUC-Cho-024537	Choloepus hoffmanni	34.97	1.00e-84	306.00
IUUC-Cin-025763	Ciona intestinalis	40.75	1.00e-110	392.00
IUUC-Csv-026113	Ciona savignyi	39.96	4.00e-107	381.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.34	6.00e-60	224.00
IUUC-Cne-026884	Cryptococcus neoformans	31.44	1.00e-68	253.00
IUUC-Cme-027210	Cyanidioschyzon merolae	25.13	5.00e-14	72.00
IUUC-Dre-028140	Danio rerio	40.82	7.00e-123	433.00
IUUC-Dno-030033	Dasypus novemcinctus	42.46	3.00e-110	391.00
IUUC-Dor-030513	Dipodomys ordii	37.19	2.00e-39	155.00
IUUC-Dse-031536	Dothistroma septosporum	30.94	3.00e-68	252.00
IUUC-Dme-031683	Drosophila melanogaster	37.76	9.00e-97	346.00
IUUC-Ete-032420	Echinops telfairi	37.90	9.00e-109	386.00
IUUC-Eca-033992	Equus caballus	40.09	4.00e-98	351.00
IUUC-Eeu-034713	Erinaceus europaeus	37.50	3.00e-33	135.00
IUUC-Fca-036548	Felis catus	42.34	8.00e-128	449.00
IUUC-Fal-037600	Ficedula albicollis	41.89	7.00e-116	410.00
IUUC-Fox-038037	Fusarium oxysporum	32.05	6.00e-72	264.00
IUUC-Fso-038387	Fusarium solani	31.89	6.00e-71	260.00
IUUC-Gmo-038562	Gadus morhua	40.34	8.00e-118	416.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.18	9.00e-64	236.00
IUUC-Gga-041129	Gallus gallus	42.56	9.00e-120	423.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.09	7.00e-122	430.00
IUUC-Gma-043610	Glycine max	67.87	0.00e+00	738.00
IUUC-Ggo-045611	Gorilla gorilla	42.48	5.00e-126	444.00
IUUC-Hsa-046563	Homo sapiens	42.72	3.00e-127	447.00
IUUC-Hvu-047790	Hordeum vulgare	96.95	0.00e+00	751.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	42.91	7.00e-127	446.00
IUUC-Kpa-049309	Komagataella pastoris	34.29	3.00e-75	275.00
IUUC-Lch-050038	Latimeria chalumnae	42.29	7.00e-122	430.00
IUUC-Lpe-051535	Leersia perrieri	83.37	0.00e+00	814.00
IUUC-Loc-051917	Lepisosteus oculatus	38.05	8.00e-107	380.00
IUUC-Lma-053112	Leptosphaeria maculans	32.68	5.00e-73	268.00
IUUC-Laf-053690	Loxodonta africana	43.50	2.00e-129	455.00
IUUC-Mcc-055117	Macaca mulatta	42.40	3.00e-124	438.00
IUUC-Meu-056761	Macropus eugenii	36.02	2.00e-92	332.00
IUUC-Mor-057230	Magnaporthe oryzae	32.01	8.00e-69	253.00
IUUC-Mpo-057514	Magnaporthe poae	32.72	5.00e-64	238.00
IUUC-Mtr-058551	Medicago truncatula	65.50	0.00e+00	711.00
IUUC-Mla-059183	Melampsora laricipopulina	35.53	4.00e-87	314.00
IUUC-Mga-060144	Meleagris gallopavo	42.05	5.00e-116	410.00
IUUC-Mvi-060221	Microbotryum violaceum	33.78	1.00e-70	259.00
IUUC-Mmr-061325	Microcebus murinus	41.92	6.00e-124	437.00
IUUC-Mdo-062532	Monodelphis domestica	43.31	2.00e-127	449.00
IUUC-Mmu-063956	Mus musculus	42.16	2.00e-126	445.00
IUUC-Mac-064521	Musa acuminata	71.95	0.00e+00	792.00
IUUC-Mpu-066716	Mustela putorius furo	42.66	3.00e-118	418.00
IUUC-Mlu-067459	Myotis lucifugus	43.21	3.00e-129	454.00
IUUC-Nfi-068245	Neosartorya fischeri	32.98	6.00e-70	257.00
IUUC-Ncr-068910	Neurospora crassa	32.60	4.00e-69	254.00
IUUC-Nle-070034	Nomascus leucogenys	41.33	1.00e-120	426.00
IUUC-Opr-070552	Ochotona princeps	38.60	1.00e-95	342.00
IUUC-Ont-071426	Oreochromis niloticus	41.24	2.00e-123	435.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.25	7.00e-87	313.00
IUUC-Ocu-074911	Oryctolagus cuniculus	43.29	1.00e-128	452.00
IUUC-Oba-075437	Oryza barthii	88.02	0.00e+00	891.00
IUUC-Obr-076684	Oryza brachyantha	86.45	0.00e+00	825.00
IUUC-Ogl-077170	Oryza glaberrima	88.02	0.00e+00	891.00
IUUC-Ogu-078844	Oryza glumaepatula	87.05	0.00e+00	840.00
IUUC-Oin-079105	Oryza indica	88.02	0.00e+00	890.00
IUUC-Olo-080943	Oryza longistaminata	84.77	0.00e+00	810.00
IUUC-Oni-082891	Oryza nivara	85.17	0.00e+00	856.00
IUUC-Opu-083457	Oryza punctata	87.83	0.00e+00	887.00
IUUC-Oru-084960	Oryza rufipogon	84.77	0.00e+00	810.00
IUUC-Osa-085358	Oryza sativa	87.64	0.00e+00	884.00
IUUC-Ola-086420	Oryzias latipes	38.32	7.00e-76	276.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.93	3.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	42.91	9.00e-128	449.00
IUUC-Oar-089196	Ovis aries	42.67	1.00e-126	446.00
IUUC-Ptr-090617	Pan troglodytes	42.72	2.00e-127	448.00
IUUC-Pan-092761	Papio anubis	42.91	2.00e-128	451.00
IUUC-Psi-093191	Pelodiscus sinensis	40.00	4.00e-120	424.00
IUUC-Pma-094380	Petromyzon marinus	40.44	3.00e-109	388.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.04	1.00e-61	231.00
IUUC-Ppa-095798	Physcomitrella patens	55.09	3.00e-174	603.00
IUUC-Pfo-096467	Poecilia formosa	40.82	5.00e-119	420.00
IUUC-Pab-098255	Pongo abelii	44.57	2.00e-108	385.00
IUUC-Pop-099722	Populus trichocarpa	69.39	0.00e+00	773.00
IUUC-Pca-100807	Procavia capensis	53.76	4.00e-56	211.00
IUUC-Ppe-101280	Prunus persica	68.06	0.00e+00	759.00
IUUC-Pva-102333	Pteropus vampyrus	41.76	1.00e-121	429.00
IUUC-Pgr-103401	Puccinia graminis	30.43	5.00e-69	254.00
IUUC-Ptt-103889	Puccinia triticina	28.60	6.00e-62	231.00
IUUC-Pte-104355	Pyrenophora teres	33.09	4.00e-71	261.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.97	2.00e-70	259.00
IUUC-Rno-105810	Rattus norvegicus	41.78	2.00e-124	438.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.66	4.00e-34	138.00
IUUC-Sha-106770	Sarcophilus harrisii	50.00	4.00e-74	270.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.40	5.00e-77	281.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.54	3.00e-83	301.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.48	4.00e-60	224.00
IUUC-Smo-109296	Selaginella moellendorffii	53.14	2.00e-164	571.00
IUUC-Sit-110157	Setaria italica	87.08	0.00e+00	946.00
IUUC-Sly-111105	Solanum lycopersicum	65.19	0.00e+00	734.00
IUUC-Stu-112469	Solanum tuberosum	65.74	0.00e+00	742.00
IUUC-Sar-113083	Sorex araneus	41.55	4.00e-46	178.00
IUUC-Sbi-113813	Sorghum bicolor	86.70	0.00e+00	944.00
IUUC-Sre-115058	Sporisorium reilianum	34.09	1.00e-64	240.00
IUUC-Tgu-116772	Taeniopygia guttata	42.48	5.00e-116	410.00
IUUC-Tru-118686	Takifugu rubripes	39.55	5.00e-121	427.00
IUUC-Tsy-119111	Tarsius syrichta	45.63	2.00e-64	238.00
IUUC-Tni-120231	Tetraodon nigroviridis	37.92	4.00e-106	377.00
IUUC-Tca-121491	Theobroma cacao	68.06	0.00e+00	724.00
IUUC-Tre-122103	Trichoderma reesei	32.71	2.00e-74	272.00
IUUC-Tvi-122672	Trichoderma virens	32.03	1.00e-68	253.00
IUUC-Tae-125684	Triticum aestivum	99.81	0.00e+00	1047.00
IUUC-Tur-126487	Triticum urartu	99.03	0.00e+00	1025.00
IUUC-Tme-127097	Tuber melanosporum	34.91	1.00e-80	293.00
IUUC-Ttr-128465	Tursiops truncatus	39.66	2.00e-112	398.00
IUUC-Uma-129645	Ustilago maydis	33.03	6.00e-63	234.00
IUUC-Vda-129989	Verticillium dahliae	29.21	1.00e-50	193.00
IUUC-Vpa-130529	Vicugna pacos	40.41	9.00e-117	413.00
IUUC-Vvi-131059	Vitis vinifera	69.77	0.00e+00	774.00
IUUC-Xtr-132002	Xenopus tropicalis	42.59	4.00e-126	444.00
IUUC-Xma-133930	Xiphophorus maculatus	41.13	1.00e-122	432.00
IUUC-Yli-134505	Yarrowia lipolytica	34.73	2.00e-82	298.00
IUUC-Zma-135895	Zea mays	85.55	0.00e+00	930.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence