iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.00e-13	53.1	24	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +D+++ vg+ +f+ah++vLaa+S +F+ lf+ + + +  +++v ++ d v + +f  ll+F+Y g+ld+
   Q: 24   CDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGS-RDTVRLNgDiVTAPAFGRLLDFMYEGRLDL 90
           8*************************8.8999999886.9******87*******************97 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.

Protein Sequence
(Fasta)

MEFPEHGGRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDRPAGS 60
RDTVRLNGDI VTAPAFGRLL DFMYEGRLDL RSLPVEDVLA AASYLHMYDI VKVCKGRLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCCCCGC CGGGGCGCGC TGCCCGCAGC TCCACGCGCG CCAGGGCCGC CCTGGGGAGG 60
GCGCGCGCGC GAGCGGCGAC CGGAGAGGAG CTCGGGGCGG CGGAGGTGAG CGCTGGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:100128927

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001524	Ailuropoda melanoleuca	63.71	2.00e-74	272.00
IUUC-Ame-011479	Astyanax mexicanus	84.92	1.00e-62	234.00
IUUC-Bta-012405	Bos taurus	90.98	1.00e-69	256.00
IUUC-Cpo-022380	Cavia porcellus	69.00	5.00e-140	490.00
IUUC-Csa-023915	Chlorocebus sabaeus	95.97	0.00e+00	731.00
IUUC-Dre-027378	Danio rerio	51.88	8.00e-107	380.00
IUUC-Itr-049050	Ictidomys tridecemlineatus	80.38	3.00e-175	608.00
IUUC-Mcc-055433	Macaca mulatta	95.50	0.00e+00	719.00
IUUC-Mdo-062104	Monodelphis domestica	54.64	2.00e-109	389.00
IUUC-Mmu-063333	Mus musculus	75.18	5.00e-159	553.00
IUUC-Oga-088319	Otolemur garnettii	67.61	5.00e-128	451.00
IUUC-Ptr-090524	Pan troglodytes	99.29	0.00e+00	758.00
IUUC-Pan-092721	Papio anubis	79.76	1.00e-161	562.00
IUUC-Pab-098701	Pongo abelii	79.38	8.00e-158	549.00
IUUC-Rno-105978	Rattus norvegicus	74.70	6.00e-158	550.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence