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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064032
Ensembl Protein ID ENSMUSP00000031680.3
UniProt Accession Q8VEK6; Q99JS6; Q9ERB2; ING3_MOUSE
Genbank Protein ID AAG23286.1; BAC38021.1; AAH05721.1; AAH18342.1
Protein Name Inhibitor of growth protein 3; p47ING3
Genbank Nucleotide ID AY007791; AK080787; BC005721; BC018342
Gene Name Ing3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029670.12 ENSMUST00000031680.9 ENSMUSP00000031680.3
ENSMUSG00000029670.12 ENSMUST00000136200.7 ENSMUSP00000138656.1
ENSMUSG00000029670.12 ENSMUST00000115389.7 ENSMUSP00000111047.1
ENSMUSG00000029670.12 ENSMUST00000151473.7 ENSMUSP00000120651.1
ENSMUSG00000029670.12 ENSMUST00000152877.7 ENSMUSP00000138244.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.20e-09 37.9 364 411
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C + + +e  +v C++  C  ewfH++C++l+   e p+ + w+Cp+C++
   Q: 364  RYC-ICNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT---EAPKGK-WFCPQCTA 411
           69*.*******99..*****999*99***********...999997.******86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).
 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).
Protein Sequence
(Fasta)
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120
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Protein Fasta Sequence


>IUUC-Mmu-064032|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGCAAGCG CCGTCAGGCG CCAAAGTGGA GCCTTTTTTT TTTTCCTTTG CTTTTTTTTT 60
TTTTTTTTTC CTTTGCCGGA GTCGAGCGGG TGCTGCTAGC GGAGGCGCCA TATTGGAAGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064032|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0004402--F:histone acetyltransferase activity
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:71777
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002275 Ailuropoda melanoleuca 95.01 0.00e+00 679.00
IUUC-Apl-003660 Anas platyrhynchos 85.19 2.00e-155 541.00
IUUC-Aca-005206 Anolis carolinensis 84.56 7.00e-165 573.00
IUUC-Ath-006765 Arabidopsis thaliana 65.22 1.00e-27 116.00
IUUC-Ame-011952 Astyanax mexicanus 80.38 4.00e-158 551.00
IUUC-Bta-012562 Bos taurus 94.54 0.00e+00 690.00
IUUC-Cja-019646 Callithrix jacchus 93.59 0.00e+00 671.00
IUUC-Cfa-020874 Canis familiaris 95.01 0.00e+00 680.00
IUUC-Cpo-022530 Cavia porcellus 94.54 0.00e+00 662.00
IUUC-Csa-024232 Chlorocebus sabaeus 94.06 0.00e+00 672.00
IUUC-Cho-025039 Choloepus hoffmanni 93.11 0.00e+00 656.00
IUUC-Cin-025233 Ciona intestinalis 58.60 3.00e-52 199.00
IUUC-Csv-025900 Ciona savignyi 61.82 4.00e-52 198.00
IUUC-Dre-027397 Danio rerio 76.83 1.00e-149 523.00
IUUC-Dno-029289 Dasypus novemcinctus 94.54 0.00e+00 677.00
IUUC-Dse-031323 Dothistroma septosporum 54.24 6.00e-18 86.30
IUUC-Ete-032510 Echinops telfairi 85.27 2.00e-154 538.00
IUUC-Eca-033770 Equus caballus 95.25 0.00e+00 680.00
IUUC-Fca-035661 Felis catus 94.30 0.00e+00 676.00
IUUC-Fal-037051 Ficedula albicollis 83.25 2.00e-151 528.00
IUUC-Gmo-039123 Gadus morhua 78.01 2.00e-161 561.00
IUUC-Gga-040794 Gallus gallus 84.09 5.00e-171 593.00
IUUC-Gac-042167 Gasterosteus aculeatus 78.07 2.00e-157 548.00
IUUC-Ggo-044586 Gorilla gorilla 96.79 3.00e-113 401.00
IUUC-Hsa-046035 Homo sapiens 94.54 0.00e+00 674.00
IUUC-Itr-048783 Ictidomys tridecemlineatus 95.25 0.00e+00 680.00
IUUC-Lch-049419 Latimeria chalumnae 82.19 7.00e-179 620.00
IUUC-Loc-052246 Lepisosteus oculatus 83.92 3.00e-165 574.00
IUUC-Lma-053234 Leptosphaeria maculans 52.31 7.00e-17 82.80
IUUC-Laf-053617 Loxodonta africana 94.30 0.00e+00 654.00
IUUC-Mcc-055192 Macaca mulatta 91.92 0.00e+00 641.00
IUUC-Meu-056848 Macropus eugenii 77.43 3.00e-142 498.00
IUUC-Mga-059899 Meleagris gallopavo 82.47 2.00e-149 521.00
IUUC-Mmr-061435 Microcebus murinus 88.84 0.00e+00 646.00
IUUC-Mpu-066530 Mustela putorius furo 95.01 0.00e+00 692.00
IUUC-Mlu-067790 Myotis lucifugus 95.01 0.00e+00 679.00
IUUC-Nle-070171 Nomascus leucogenys 94.54 0.00e+00 674.00
IUUC-Opr-070865 Ochotona princeps 74.65 1.00e-75 276.00
IUUC-Ont-072045 Oreochromis niloticus 80.47 6.00e-158 550.00
IUUC-Oan-073641 Ornithorhynchus anatinus 85.49 1.00e-157 549.00
IUUC-Ocu-074613 Oryctolagus cuniculus 95.25 0.00e+00 682.00
IUUC-Oga-088624 Otolemur garnettii 94.55 0.00e+00 667.00
IUUC-Oar-089442 Ovis aries 93.59 0.00e+00 679.00
IUUC-Ptr-091208 Pan troglodytes 94.54 0.00e+00 674.00
IUUC-Pan-092715 Papio anubis 94.30 0.00e+00 672.00
IUUC-Psi-093455 Pelodiscus sinensis 82.66 4.00e-169 587.00
IUUC-Pma-094144 Petromyzon marinus 78.65 5.00e-44 169.00
IUUC-Pfo-096573 Poecilia formosa 81.56 1.00e-158 552.00
IUUC-Pab-097549 Pongo abelii 94.54 0.00e+00 674.00
IUUC-Pca-100198 Procavia capensis 92.40 0.00e+00 655.00
IUUC-Pva-102440 Pteropus vampyrus 93.59 0.00e+00 671.00
IUUC-Pte-104284 Pyrenophora teres 52.54 7.00e-17 82.80
IUUC-Pyt-104787 Pyrenophora triticirepentis 54.24 5.00e-17 83.20
IUUC-Rno-105532 Rattus norvegicus 98.81 0.00e+00 698.00
IUUC-Sha-107475 Sarcophilus harrisii 84.56 6.00e-180 623.00
IUUC-Sar-113193 Sorex araneus 93.11 0.00e+00 659.00
IUUC-Ssc-115795 Sus scrofa 94.30 0.00e+00 675.00
IUUC-Tgu-117305 Taeniopygia guttata 87.37 1.00e-151 528.00
IUUC-Tru-117691 Takifugu rubripes 78.07 4.00e-152 531.00
IUUC-Tsy-119035 Tarsius syrichta 85.32 3.00e-94 338.00
IUUC-Tni-120738 Tetraodon nigroviridis 78.25 1.00e-159 556.00
IUUC-Ttr-128512 Tursiops truncatus 93.59 0.00e+00 679.00
IUUC-Xma-133522 Xiphophorus maculatus 81.80 3.00e-159 554.00
IUUC-Zma-135298 Zea mays 66.10 3.00e-24 105.00
Created Date 25-Jun-2017

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