iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028427

Ensembl Protein ID

ENSDARP00000109363.1

UniProt Accession

E7EZ59; E7EZ59_DANRE

Genbank Protein ID

ENSDARP00000109363

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Genbank Nucleotide ID

FP017279

Gene Name

wdr4; WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000090581.2	ENSDART00000122894.2	ENSDARP00000109363.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-07	30.2	187	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v++l      + + l+sGs+Dgt+ vW + tg+ l+
   Q: 187  GHTEFVSSLLVpaghP-DWLLSGSGDGTVNVWHYETGRRLH 226
           7999999985478655.779**************9999876 PP

Organism

Danio rerio

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MAVVCSKADW FVTSCSTTLV AVNLKQSREP FVFDCSKAEK KPKEADVDNK SAGEGSEEKD 60
SDSILAFAIS ASGKHVALTD DHKRLVLFCT EPSWKCISTR WVVRRCTSLA FTQAEDELYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGTGCGA CTGTCAGTTC GCACGTGAAC AACACTCAAC ATGGCTGTAG TGTGTTCAAA 60
AGCTGACTGG TTTGTTACAA GTTGTTCTAC TACTTTAGTT GCTGTAAACC TTAAGCAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation

KEGG

dre:570351

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	30.00	4.00e-12	66.20
IUUC-Atr-002431	Amborella trichopoda	34.07	4.00e-12	63.90
IUUC-Apl-003975	Anas platyrhynchos	46.17	2.00e-90	326.00
IUUC-Aca-005170	Anolis carolinensis	46.69	3.00e-79	288.00
IUUC-Aly-005769	Arabidopsis lyrata	32.22	3.00e-25	109.00
IUUC-Ath-006733	Arabidopsis thaliana	32.08	9.00e-25	107.00
IUUC-Acl-008151	Aspergillus clavatus	33.33	7.00e-18	85.50
IUUC-Afl-008518	Aspergillus flavus	28.72	9.00e-21	94.40
IUUC-Afu-009102	Aspergillus fumigatus	27.87	1.00e-21	98.20
IUUC-Ani-009442	Aspergillus nidulans	29.85	2.00e-18	87.00
IUUC-Aor-010133	Aspergillus oryzae	28.22	1.00e-22	101.00
IUUC-Ate-010465	Aspergillus terreus	27.07	2.00e-17	84.30
IUUC-Ame-010613	Astyanax mexicanus	68.11	4.00e-152	531.00
IUUC-Bgr-012067	Blumeria graminis	30.38	2.00e-21	97.10
IUUC-Bta-012788	Bos taurus	46.23	5.00e-89	321.00
IUUC-Bdi-014458	Brachypodium distachyon	34.19	7.00e-17	82.00
IUUC-Bol-016398	Brassica oleracea	34.31	1.00e-27	117.00
IUUC-Bra-016644	Brassica rapa	33.61	4.00e-24	107.00
IUUC-Cpo-021963	Cavia porcellus	46.86	4.00e-84	305.00
IUUC-Csa-024148	Chlorocebus sabaeus	47.67	2.00e-78	286.00
IUUC-Cne-026834	Cryptococcus neoformans	32.98	4.00e-20	93.20
IUUC-Dno-028881	Dasypus novemcinctus	41.29	1.00e-68	253.00
IUUC-Dor-030522	Dipodomys ordii	45.84	5.00e-90	324.00
IUUC-Dme-032136	Drosophila melanogaster	35.79	2.00e-21	97.10
IUUC-Fca-035833	Felis catus	45.58	3.00e-83	302.00
IUUC-Fal-037497	Ficedula albicollis	47.66	7.00e-92	330.00
IUUC-Gga-040547	Gallus gallus	46.82	1.00e-88	320.00
IUUC-Gac-041761	Gasterosteus aculeatus	53.32	5.00e-111	394.00
IUUC-Gma-043722	Glycine max	34.45	8.00e-24	104.00
IUUC-Ggo-045340	Gorilla gorilla	47.09	6.00e-79	287.00
IUUC-Hsa-046403	Homo sapiens	47.09	6.00e-79	288.00
IUUC-Hvu-047643	Hordeum vulgare	33.82	5.00e-20	92.40
IUUC-Itr-048103	Ictidomys tridecemlineatus	46.92	9.00e-89	320.00
IUUC-Kpa-049283	Komagataella pastoris	33.33	2.00e-19	90.50
IUUC-Lch-050682	Latimeria chalumnae	48.18	3.00e-97	348.00
IUUC-Lpe-050712	Leersia perrieri	35.17	5.00e-25	108.00
IUUC-Loc-052599	Lepisosteus oculatus	58.09	8.00e-133	466.00
IUUC-Laf-054390	Loxodonta africana	46.93	2.00e-89	322.00
IUUC-Mcc-054747	Macaca mulatta	47.67	6.00e-80	291.00
IUUC-Mtr-058600	Medicago truncatula	38.91	7.00e-27	115.00
IUUC-Mla-059135	Melampsora laricipopulina	28.12	1.00e-12	68.20
IUUC-Mga-059876	Meleagris gallopavo	46.96	5.00e-91	327.00
IUUC-Mvi-060359	Microbotryum violaceum	30.81	1.00e-12	68.20
IUUC-Mmr-061518	Microcebus murinus	46.51	6.00e-82	297.00
IUUC-Mac-065625	Musa acuminata	31.07	6.00e-22	99.00
IUUC-Nfi-068402	Neosartorya fischeri	27.45	1.00e-20	94.70
IUUC-Nle-069914	Nomascus leucogenys	46.51	3.00e-75	275.00
IUUC-Ont-071555	Oreochromis niloticus	53.48	6.00e-116	410.00
IUUC-Oan-072951	Ornithorhynchus anatinus	48.42	3.00e-93	335.00
IUUC-Ocu-074679	Oryctolagus cuniculus	46.80	5.00e-80	291.00
IUUC-Oba-075355	Oryza barthii	25.40	4.00e-10	59.70
IUUC-Obr-076769	Oryza brachyantha	32.53	3.00e-27	116.00
IUUC-Ogl-077168	Oryza glaberrima	29.47	2.00e-24	106.00
IUUC-Ogu-078275	Oryza glumaepatula	25.13	1.00e-09	58.20
IUUC-Oin-079207	Oryza indica	29.47	2.00e-24	106.00
IUUC-Oni-082437	Oryza nivara	26.19	4.00e-10	59.70
IUUC-Opu-084031	Oryza punctata	30.00	5.00e-24	105.00
IUUC-Oru-084380	Oryza rufipogon	25.40	6.00e-10	58.90
IUUC-Osa-085327	Oryza sativa	29.47	4.00e-24	105.00
IUUC-Ola-086716	Oryzias latipes	54.79	2.00e-112	399.00
IUUC-Olu-087708	Ostreococcus lucimarinus	29.10	4.00e-17	82.40
IUUC-Oar-090239	Ovis aries	47.99	1.00e-89	323.00
IUUC-Ptr-090851	Pan troglodytes	47.38	1.00e-79	290.00
IUUC-Pan-092558	Papio anubis	47.40	1.00e-76	280.00
IUUC-Psi-093792	Pelodiscus sinensis	47.09	2.00e-88	319.00
IUUC-Ppa-095757	Physcomitrella patens	36.61	4.00e-26	112.00
IUUC-Pfo-096465	Poecilia formosa	53.83	3.00e-119	422.00
IUUC-Pab-097722	Pongo abelii	48.30	2.00e-83	302.00
IUUC-Pop-098979	Populus trichocarpa	37.95	4.00e-22	99.00
IUUC-Pca-100753	Procavia capensis	46.40	7.00e-62	231.00
IUUC-Ppe-101515	Prunus persica	34.45	4.00e-25	109.00
IUUC-Sja-107780	Schizosaccharomyces japonicus	25.66	3.00e-16	79.70
IUUC-Spo-108251	Schizosaccharomyces pombe	27.62	6.00e-17	82.00
IUUC-Smo-108938	Selaginella moellendorffii	31.11	5.00e-22	99.00
IUUC-Sit-110020	Setaria italica	30.65	3.00e-24	106.00
IUUC-Sly-111543	Solanum lycopersicum	33.33	5.00e-28	119.00
IUUC-Stu-111925	Solanum tuberosum	32.00	1.00e-28	120.00
IUUC-Sbi-114061	Sorghum bicolor	36.44	6.00e-25	108.00
IUUC-Tgu-117321	Taeniopygia guttata	47.41	2.00e-84	305.00
IUUC-Tru-118454	Takifugu rubripes	53.44	1.00e-106	379.00
IUUC-Tni-119894	Tetraodon nigroviridis	51.86	3.00e-96	345.00
IUUC-Tca-121746	Theobroma cacao	33.47	2.00e-23	103.00
IUUC-Tae-124459	Triticum aestivum	33.45	2.00e-21	97.10
IUUC-Tur-126254	Triticum urartu	30.57	1.00e-13	70.50
IUUC-Tbe-127683	Tupaia belangeri	63.51	4.00e-25	109.00
IUUC-Ttr-129056	Tursiops truncatus	45.35	2.00e-78	286.00
IUUC-Vvi-131428	Vitis vinifera	35.39	1.00e-23	104.00
IUUC-Xma-133605	Xiphophorus maculatus	53.55	7.00e-119	420.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence