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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063777
Ensembl Protein ID ENSMUSP00000047333.8
UniProt Accession O88939; B2RRP7; B7ZNL6; Q3U372; Q9CRJ0; ZBT7A_MOUSE
Genbank Protein ID AAC35367.1; BAB26897.1; BAE32917.1; EDL31455.1; AAH57204.1; AAI38525.1; AAI45312.1
Protein Name Zinc finger and BTB domain-containing protein 7A; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor
Genbank Nucleotide ID AF086830; AK010379; AK154907; CH466553; BC057204; BC138524; BC145311
Gene Name Zbtb7a; Lrf; Zbtb7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035011.15 ENSMUST00000048128.14 ENSMUSP00000047333.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRecordsRepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 9.60e-16 59.0 34 99
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+g+ef++h++vLaa+S++F++lf+++    + ++ +ei+ v++e++ al++F Yt +l+ 
   Q: 34   CDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQ-QNVYEIDFVSAEALTALMDFAYTATLTV 99
           8**********************************666.9**********************99975 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.
 Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals. Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'.
Protein Sequence
(Fasta)
MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 60
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063777|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGTGAAA AAAAAAGAAA GAAAGAAAGA AAGAAAACAG AAAACGCAGG GTTGGATTCG 60
CACTTTCCTA CTTCCCACCT CTGTCCTGCG GAGCTGTGCG GCGCCCCTGC GAGGGTCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063777|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035035--F:histone acetyltransferase binding
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0051216--P:cartilage development
GO:0030154--P:cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:16969
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001947 Ailuropoda melanoleuca 92.68 1.00e-83 301.00
IUUC-Apl-003455 Anas platyrhynchos 65.24 0.00e+00 651.00
IUUC-Ame-011315 Astyanax mexicanus 65.60 1.00e-79 290.00
IUUC-Bta-012885 Bos taurus 84.95 0.00e+00 770.00
IUUC-Cja-019289 Callithrix jacchus 82.88 0.00e+00 778.00
IUUC-Cfa-020143 Canis familiaris 87.04 0.00e+00 747.00
IUUC-Cpo-021474 Cavia porcellus 80.07 0.00e+00 764.00
IUUC-Csa-024242 Chlorocebus sabaeus 81.26 0.00e+00 731.00
IUUC-Cin-025467 Ciona intestinalis 44.64 1.00e-25 108.00
IUUC-Dre-027425 Danio rerio 49.81 4.00e-124 438.00
IUUC-Dno-029452 Dasypus novemcinctus 81.04 6.00e-176 610.00
IUUC-Dor-031002 Dipodomys ordii 89.04 0.00e+00 652.00
IUUC-Eeu-034736 Erinaceus europaeus 89.47 2.00e-83 303.00
IUUC-Fal-037513 Ficedula albicollis 68.16 0.00e+00 677.00
IUUC-Gga-040265 Gallus gallus 69.84 0.00e+00 637.00
IUUC-Gac-041962 Gasterosteus aculeatus 70.56 5.00e-85 308.00
IUUC-Ggo-045371 Gorilla gorilla 66.07 2.00e-171 595.00
IUUC-Hsa-046303 Homo sapiens 85.05 0.00e+00 803.00
IUUC-Itr-047921 Ictidomys tridecemlineatus 87.95 3.00e-87 315.00
IUUC-Lch-049776 Latimeria chalumnae 55.96 2.00e-153 536.00
IUUC-Loc-052112 Lepisosteus oculatus 67.87 3.00e-82 299.00
IUUC-Meu-056706 Macropus eugenii 74.55 0.00e+00 697.00
IUUC-Mga-060164 Meleagris gallopavo 69.23 0.00e+00 632.00
IUUC-Mmr-061124 Microcebus murinus 82.65 0.00e+00 700.00
IUUC-Mdo-061864 Monodelphis domestica 88.10 6.00e-104 370.00
IUUC-Mpu-065739 Mustela putorius furo 86.25 0.00e+00 779.00
IUUC-Mlu-067158 Myotis lucifugus 82.03 0.00e+00 733.00
IUUC-Opr-070700 Ochotona princeps 74.35 0.00e+00 660.00
IUUC-Ont-071557 Oreochromis niloticus 60.00 4.00e-79 289.00
IUUC-Oan-073589 Ornithorhynchus anatinus 76.72 5.00e-101 361.00
IUUC-Oga-089163 Otolemur garnettii 84.29 0.00e+00 806.00
IUUC-Oar-089886 Ovis aries 84.91 0.00e+00 728.00
IUUC-Ptr-091558 Pan troglodytes 85.05 0.00e+00 803.00
IUUC-Pan-092337 Papio anubis 81.26 0.00e+00 731.00
IUUC-Psi-093220 Pelodiscus sinensis 70.76 0.00e+00 653.00
IUUC-Pma-094176 Petromyzon marinus 41.72 7.00e-28 118.00
IUUC-Pfo-096769 Poecilia formosa 63.60 3.00e-78 286.00
IUUC-Pab-097551 Pongo abelii 86.59 2.00e-175 608.00
IUUC-Pva-102777 Pteropus vampyrus 77.74 0.00e+00 662.00
IUUC-Rno-106040 Rattus norvegicus 97.19 0.00e+00 882.00
IUUC-Sha-107596 Sarcophilus harrisii 71.75 0.00e+00 659.00
IUUC-Ssc-116026 Sus scrofa 83.83 0.00e+00 810.00
IUUC-Tru-118073 Takifugu rubripes 65.52 7.00e-71 261.00
IUUC-Tni-120736 Tetraodon nigroviridis 71.90 8.00e-83 300.00
IUUC-Ttr-128563 Tursiops truncatus 82.01 0.00e+00 731.00
Created Date 25-Jun-2017

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