iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046368

Ensembl Protein ID

ENSP00000455417.1

UniProt Accession

Q12789; B2RP21; Q12838; Q6DKN9; Q9Y4W9; TF3C1_HUMAN

Genbank Protein ID

AAA17985.1; AAB67637.1; AAC05811.1; AAH44857.1; AAI37230.1; AAA85638.1

Protein Name

General transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC box B-binding subunit; Transcription factor IIIC 220 kDa subunit; Transcription factor IIIC subunit alpha

Genbank Nucleotide ID

U02619; AC002303; AC025275; BC044857; BC137229; U06485

Gene Name

GTF3C1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000077235.17	ENST00000561623.5	ENSP00000455417.1
ENSG00000077235.17	ENST00000356183.8	ENSP00000348510.4
ENSG00000077235.17	ENST00000569653.1	ENSP00000457449.1
ENSG00000077235.17	ENST00000564664.5	ENSP00000457476.1
ENSG00000077235.17	ENST00000568569.1	ENSP00000456187.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	23.81	1.30e-01	35.00	IUUC-Sce-106188

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.

Protein Sequence
(Fasta)

MDALESLLDE VALEGLDGLC LPALWSRLET RVPPFPLPLE PCTQEFLWRA LATHPGISFY 60
EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVALEDVYPI HMILENKDGI QGSCRYFKER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGCCGCC GACTGAAGTA GCAATGGACG CGCTGGAGTC GTTGTTGGAC GAAGTCGCTC 60
TGGAGGGGCT CGATGGCCTG TGTCTGCCAG CGCTGTGGAG CCGGCTGGAG ACGCGAGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0832--Ubl conjugation

Interpro

IPR007309--TFIIIC_Bblock-bd

Pfam

PF04182--B-block_TFIIIC

Gene Ontology

GO:0030529--C:intracellular ribonucleoprotein complex
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000127--C:transcription factor TFIIIC complex
GO:0001002--F:RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001003--F:RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:0001007--F:transcription factor activity, RNA polymerase III transcription factor binding
GO:0042791--P:5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0009303--P:rRNA transcription
GO:0006383--P:transcription from RNA polymerase III promoter
GO:0006384--P:transcription initiation from RNA polymerase III promoter
GO:0006351--P:transcription, DNA-templated
GO:0009304--P:tRNA transcription
GO:0042797--P:tRNA transcription from RNA polymerase III promoter

KEGG

hsa:2975

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001476	Ailuropoda melanoleuca	81.93	0.00e+00	3318.00
IUUC-Apl-004061	Anas platyrhynchos	65.27	0.00e+00	2558.00
IUUC-Cja-019252	Callithrix jacchus	96.90	0.00e+00	2778.00
IUUC-Cfa-020574	Canis familiaris	78.46	0.00e+00	3093.00
IUUC-Cpo-021734	Cavia porcellus	75.87	0.00e+00	2966.00
IUUC-Csa-023992	Chlorocebus sabaeus	96.30	0.00e+00	3873.00
IUUC-Fal-036950	Ficedula albicollis	67.58	0.00e+00	2256.00
IUUC-Ggo-045640	Gorilla gorilla	97.84	0.00e+00	3747.00
IUUC-Itr-048444	Ictidomys tridecemlineatus	80.67	0.00e+00	3178.00
IUUC-Mcc-054783	Macaca mulatta	95.12	0.00e+00	3855.00
IUUC-Mmu-064164	Mus musculus	82.49	0.00e+00	2328.00
IUUC-Mpu-066051	Mustela putorius furo	78.45	0.00e+00	3125.00
IUUC-Nle-069462	Nomascus leucogenys	97.94	0.00e+00	3204.00
IUUC-Ptr-091115	Pan troglodytes	97.97	0.00e+00	3665.00
IUUC-Pab-097831	Pongo abelii	94.07	0.00e+00	3702.00
IUUC-Rno-105571	Rattus norvegicus	76.41	0.00e+00	2989.00
IUUC-Sce-106188	Saccharomyces cerevisiae	23.81	1.90e-02	35.00
IUUC-Tgu-116880	Taeniopygia guttata	64.07	0.00e+00	2531.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence