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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045848
Ensembl Protein ID ENSP00000270708.7
UniProt Accession Q9P2S5; Q5T0D6; Q9BUH7; Q9NTK7; Q9NX56; WRP73_HUMAN
Genbank Protein ID BAA92312.1; BAA91164.1; CAI19128.1; CAI19128.1; CAI19129.1; CAI19129.1; CAI14335.1; CAI14335.1; CAI14336.1; CAI14336.1; AAH86311.1
Protein Name WD repeat-containing protein WRAP73; WD repeat-containing protein 8; WD repeat-containing protein antisense to TP73 gene
Genbank Nucleotide ID AB034912; AK000437; AL136528; AL513320; AL136528; AL513320; AL513320; AL136528; AL513320; AL136528; BC086311
Gene Name WRAP73; WDR8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116213.15 ENST00000378322.7 ENSP00000367573.3
ENSG00000116213.15 ENST00000270708.11 ENSP00000270708.7
ENSG00000116213.15 ENST00000424367.5 ENSP00000416192.1
ENSG00000116213.15 ENST00000419924.2 ENSP00000389738.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.70e-06 27.9 226 251
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 6    vtclaf.sd.tllvsGsdDgtikvWD 29
           + ++a+ ++  +l++Gs+Dg++++ +
   Q: 226  IKSVAWsPSsQFLAVGSYDGKVRILN 251
           889****666*************976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).
 The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).
Protein Sequence
(Fasta)
MNFSEVFKLS SLLCKFSPDG KYLASCVQYR LVVRDVNTLQ ILQLYTCLDQ IQHIEWSADS 60
LFILCAMYKR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS 120
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Protein Fasta Sequence


>IUUC-Hsa-045848|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCCCCGATCG CTCTCCCCTC ACCTCCCAGC TTCGGAGCTG CGAGCCCAGG TGCCTGCCCA 60
GCGCTGCGCT CCAGCCCCCG CCCGCGGAGC CGAACCGCCC CCCGGCCCTG GGCCTCCTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045848|E3,WD_repeat|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
Pfam

PF12894--ANAPC4_WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0030030--P:cell projection organization
GO:0090307--P:mitotic spindle assembly
GO:1902857--P:positive regulation of non-motile cilium assembly
KEGG hsa:49856
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001962 Ailuropoda melanoleuca 89.35 0.00e+00 833.00
IUUC-Ame-011800 Astyanax mexicanus 72.87 0.00e+00 694.00
IUUC-Bta-012871 Bos taurus 87.39 0.00e+00 834.00
IUUC-Cja-019673 Callithrix jacchus 93.68 0.00e+00 863.00
IUUC-Cfa-020819 Canis familiaris 89.78 0.00e+00 871.00
IUUC-Cpo-021547 Cavia porcellus 89.21 0.00e+00 821.00
IUUC-Csa-023788 Chlorocebus sabaeus 98.04 0.00e+00 899.00
IUUC-Cin-025531 Ciona intestinalis 52.36 3.00e-145 508.00
IUUC-Dre-027827 Danio rerio 72.42 0.00e+00 678.00
IUUC-Dno-029109 Dasypus novemcinctus 86.48 0.00e+00 769.00
IUUC-Dor-030894 Dipodomys ordii 86.74 0.00e+00 839.00
IUUC-Eca-033543 Equus caballus 92.39 0.00e+00 870.00
IUUC-Eeu-034534 Erinaceus europaeus 80.00 0.00e+00 748.00
IUUC-Fca-035577 Felis catus 83.26 0.00e+00 797.00
IUUC-Ggo-044595 Gorilla gorilla 99.57 0.00e+00 947.00
IUUC-Itr-048797 Ictidomys tridecemlineatus 90.33 0.00e+00 832.00
IUUC-Mmu-063452 Mus musculus 88.65 0.00e+00 857.00
IUUC-Mpu-065795 Mustela putorius furo 88.70 0.00e+00 827.00
IUUC-Mlu-067626 Myotis lucifugus 83.95 0.00e+00 800.00
IUUC-Nle-069334 Nomascus leucogenys 93.48 0.00e+00 877.00
IUUC-Opr-071133 Ochotona princeps 85.51 2.00e-134 472.00
IUUC-Ogu-078740 Oryza glumaepatula 49.02 3.00e-119 423.00
IUUC-Oar-090219 Ovis aries 74.95 0.00e+00 722.00
IUUC-Ptr-090500 Pan troglodytes 99.13 0.00e+00 943.00
IUUC-Pan-092844 Papio anubis 97.83 0.00e+00 895.00
IUUC-Pfo-097218 Poecilia formosa 72.65 0.00e+00 686.00
IUUC-Pab-097585 Pongo abelii 98.91 0.00e+00 939.00
IUUC-Tni-120612 Tetraodon nigroviridis 69.06 0.00e+00 682.00
IUUC-Tbe-127387 Tupaia belangeri 90.22 0.00e+00 862.00
IUUC-Ttr-129229 Tursiops truncatus 86.30 0.00e+00 819.00
Created Date 25-Jun-2017

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