iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054128

Ensembl Protein ID

ENSLAFP00000026496.1

UniProt Accession

G3UF88; G3UF88_LOXAF

Protein Name

Tyrosine-protein kinase

Gene Name

FGR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011018.3	ENSLAFT00000025806.1	ENSLAFP00000026496.1
ENSLAFG00000011018.3	ENSLAFT00000011018.3	ENSLAFP00000009217.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-15	56.9	79	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydy+a ++d+Lt++kG++ +++  ++ +++W++  + ++g+ G +P+n+v+ ++
   Q: 79   LFIALYDYKARTEDDLTFTKGEKFHIL--NNSEGDWWEVRSLTSGQTGYIPSNYVAPVD 135
           5789***********************..88999*********************9987 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGCVFCKKLE PESKEDIGLE GNLRGYGAGD RYCPDPTQAR SVSSFAHIPN YNNFSPSPTS 60
PAFLDGSTIR GISGTGVTLF IALYDYKART EDDLTFTKGE KFHILNNSEG DWWEVRSLTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGTG TGTTCTGCAA GAAGCTGGAG CCGGAGTCCA AGGAGGATAT TGGCCTGGAA 60
GGAAACCTCA GGGGCTATGG GGCTGGTGAC CGCTATTGCC CTGACCCCAC TCAGGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007229--P:integrin-mediated signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0046777--P:protein autophosphorylation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity

KEGG

lav:100654897

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	90.32	0.00e+00	1005.00
IUUC-Bta-012607	Bos taurus	88.61	0.00e+00	992.00
IUUC-Cja-018914	Callithrix jacchus	84.07	0.00e+00	941.00
IUUC-Cfa-020165	Canis familiaris	89.18	0.00e+00	994.00
IUUC-Cpo-021476	Cavia porcellus	87.29	0.00e+00	959.00
IUUC-Csa-023692	Chlorocebus sabaeus	86.96	0.00e+00	979.00
IUUC-Dno-028920	Dasypus novemcinctus	87.48	0.00e+00	978.00
IUUC-Eca-033581	Equus caballus	90.89	0.00e+00	1018.00
IUUC-Fca-036499	Felis catus	89.56	0.00e+00	1002.00
IUUC-Ggo-044640	Gorilla gorilla	87.33	0.00e+00	980.00
IUUC-Hsa-046751	Homo sapiens	87.15	0.00e+00	978.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	88.24	0.00e+00	982.00
IUUC-Mcc-054715	Macaca mulatta	87.15	0.00e+00	980.00
IUUC-Meu-056155	Macropus eugenii	81.46	0.00e+00	776.00
IUUC-Mmr-060615	Microcebus murinus	90.77	0.00e+00	998.00
IUUC-Mmu-063286	Mus musculus	83.68	0.00e+00	936.00
IUUC-Mpu-066641	Mustela putorius furo	90.51	0.00e+00	1009.00
IUUC-Oan-073486	Ornithorhynchus anatinus	78.65	0.00e+00	878.00
IUUC-Ocu-074552	Oryctolagus cuniculus	89.16	0.00e+00	978.00
IUUC-Oga-088731	Otolemur garnettii	90.13	0.00e+00	1009.00
IUUC-Oar-090207	Ovis aries	88.24	0.00e+00	985.00
IUUC-Ptr-090979	Pan troglodytes	87.15	0.00e+00	978.00
IUUC-Pan-092188	Papio anubis	87.33	0.00e+00	981.00
IUUC-Pab-098617	Pongo abelii	87.15	0.00e+00	981.00
IUUC-Pca-100834	Procavia capensis	80.27	0.00e+00	859.00
IUUC-Rno-104945	Rattus norvegicus	83.49	0.00e+00	917.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence