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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105487
Ensembl Protein ID ENSRNOP00000052531.4
UniProt Accession Q2HWF0; Q2HWE9; FBP1L_RAT
Genbank Protein ID BAE79635.1; BAE79636.1; ENSRNOP00000019244
Protein Name Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1
Genbank Nucleotide ID AB250295; AB250296; AABR03012297
Gene Name Fnbp1l; Toca1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000013798.8 ENSRNOT00000055669.4 ENSRNOP00000052531.4
ENSRNOG00000013798.8 ENSRNOT00000019244.6 ENSRNOP00000019244.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.80e-10 41.0 543 595
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++++y++++ n+++L +k+G+v+++i +e++  gW ++ +  +g +G +P  ++ 
   Q: 543  CKAIYPFDGHNEGTLAMKEGEVLYII-EEDKGDGWTRA-RRQNGEEGYVPTTYID 595
           99************************.999999*****.59**********9996 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.
 Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.
Protein Sequence
(Fasta)
MSWGTELWDQ FDSLDKHTQW GIDFLERYAK FVKERIEIEQ NYAKQLRNLV KKYCPKRSSK 60
DEEPRFTSCI AFFNILNELN DYAGQREVVA EEMAHRVYGE LMRYAHDLKT ERKMHLQEGR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105487|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCGGGGAC GCGGCGGCAG CTCGCTTCAG TCGTGTCTCT CTCACTCACT GGGGAACCCG 60
GTGGTGGCGG CAGCTTTCGA GGCAGACACT TGCCGGCCCG GTCCTGAGAA GGGAAAGTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105487|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR030116--FNBP1L
IPR011072--HR1_rho-bd
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF00018--SH3_1
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0008289--F:lipid binding
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0060271--P:cilium assembly
GO:0072583--P:clathrin-dependent endocytosis
GO:0006900--P:membrane budding
GO:0010324--P:membrane invagination
GO:0007399--P:nervous system development
GO:0097320--P:plasma membrane tubulation
GO:0051491--P:positive regulation of filopodium assembly
GO:0030050--P:vesicle transport along actin filament
KEGG rno:310839
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002284 Ailuropoda melanoleuca 97.36 0.00e+00 1176.00
IUUC-Apl-003448 Anas platyrhynchos 91.07 0.00e+00 1105.00
IUUC-Acl-008089 Aspergillus clavatus 24.02 2.00e-13 71.60
IUUC-Afl-008472 Aspergillus flavus 23.77 1.00e-11 65.50
IUUC-Afu-009118 Aspergillus fumigatus 24.43 8.00e-16 79.00
IUUC-Ang-009697 Aspergillus niger 22.61 5.00e-11 63.20
IUUC-Aor-010089 Aspergillus oryzae 24.05 4.00e-13 70.10
IUUC-Ate-010418 Aspergillus terreus 22.65 4.00e-11 63.50
IUUC-Bgr-012268 Blumeria graminis 24.51 2.00e-14 74.70
IUUC-Bta-013289 Bos taurus 87.09 0.00e+00 1042.00
IUUC-Bci-013658 Botrytis cinerea 26.55 9.00e-09 55.80
IUUC-Cja-019157 Callithrix jacchus 97.32 0.00e+00 1159.00
IUUC-Cfa-021263 Canis familiaris 97.00 0.00e+00 1157.00
IUUC-Cpo-022162 Cavia porcellus 96.82 0.00e+00 1141.00
IUUC-Csa-024094 Chlorocebus sabaeus 87.60 0.00e+00 1055.00
IUUC-Cho-024432 Choloepus hoffmanni 83.31 0.00e+00 1003.00
IUUC-Dno-030053 Dasypus novemcinctus 87.60 0.00e+00 1037.00
IUUC-Dor-030954 Dipodomys ordii 87.60 0.00e+00 1021.00
IUUC-Dse-031554 Dothistroma septosporum 23.91 8.00e-08 52.40
IUUC-Ete-033202 Echinops telfairi 80.66 0.00e+00 961.00
IUUC-Eca-034433 Equus caballus 97.15 0.00e+00 1153.00
IUUC-Fca-036316 Felis catus 97.35 0.00e+00 1172.00
IUUC-Fal-037482 Ficedula albicollis 81.15 0.00e+00 870.00
IUUC-Fox-037938 Fusarium oxysporum 24.56 6.00e-14 72.80
IUUC-Fso-038099 Fusarium solani 26.45 3.00e-14 73.90
IUUC-Ggr-040011 Gaeumannomyces graminis 23.77 5.00e-11 63.20
IUUC-Gga-040893 Gallus gallus 83.14 0.00e+00 1006.00
IUUC-Ggo-045368 Gorilla gorilla 97.03 0.00e+00 1175.00
IUUC-Hsa-046014 Homo sapiens 97.52 0.00e+00 1187.00
IUUC-Itr-048450 Ictidomys tridecemlineatus 96.18 0.00e+00 888.00
IUUC-Lch-049559 Latimeria chalumnae 78.08 0.00e+00 638.00
IUUC-Laf-053633 Loxodonta africana 96.03 0.00e+00 1159.00
IUUC-Mcc-055726 Macaca mulatta 97.69 0.00e+00 1189.00
IUUC-Mor-057091 Magnaporthe oryzae 25.00 3.00e-10 60.50
IUUC-Mpo-057513 Magnaporthe poae 23.36 2.00e-10 61.60
IUUC-Mla-059151 Melampsora laricipopulina 22.43 1.00e-10 62.00
IUUC-Mga-059482 Meleagris gallopavo 80.99 0.00e+00 972.00
IUUC-Mmr-061011 Microcebus murinus 97.19 0.00e+00 1181.00
IUUC-Mdo-062199 Monodelphis domestica 95.85 0.00e+00 1159.00
IUUC-Mmu-064089 Mus musculus 98.51 0.00e+00 1199.00
IUUC-Mpu-065924 Mustela putorius furo 87.77 0.00e+00 1055.00
IUUC-Mlu-068188 Myotis lucifugus 91.40 0.00e+00 1092.00
IUUC-Nfi-068456 Neosartorya fischeri 24.43 6.00e-16 79.30
IUUC-Ncr-068849 Neurospora crassa 22.82 1.00e-10 61.60
IUUC-Nle-070050 Nomascus leucogenys 97.15 0.00e+00 1162.00
IUUC-Opr-071010 Ochotona princeps 82.06 5.00e-120 424.00
IUUC-Oan-073051 Ornithorhynchus anatinus 93.40 0.00e+00 1116.00
IUUC-Ocu-074906 Oryctolagus cuniculus 97.85 0.00e+00 1189.00
IUUC-Oba-075410 Oryza barthii 34.21 8.50e-01 29.30
IUUC-Ogl-077729 Oryza glaberrima 34.21 8.50e-01 29.30
IUUC-Ogu-077953 Oryza glumaepatula 34.21 8.50e-01 29.60
IUUC-Oin-079638 Oryza indica 36.11 2.00e-01 28.90
IUUC-Oru-084884 Oryza rufipogon 34.21 8.50e-01 29.30
IUUC-Osa-085690 Oryza sativa 34.21 8.50e-01 29.30
IUUC-Oga-088792 Otolemur garnettii 96.05 0.00e+00 1154.00
IUUC-Oar-090267 Ovis aries 96.85 0.00e+00 1162.00
IUUC-Ptr-091071 Pan troglodytes 97.69 0.00e+00 1188.00
IUUC-Pan-092738 Papio anubis 87.44 0.00e+00 1040.00
IUUC-Psi-093274 Pelodiscus sinensis 84.09 0.00e+00 1002.00
IUUC-Pab-098294 Pongo abelii 97.85 0.00e+00 1189.00
IUUC-Pgr-103504 Puccinia graminis 20.95 6.00e-11 62.80
IUUC-Pyt-104583 Pyrenophora triticirepentis 24.24 4.00e-08 53.50
IUUC-Sce-106410 Saccharomyces cerevisiae 20.93 1.00e-11 65.10
IUUC-Sha-107064 Sarcophilus harrisii 93.96 0.00e+00 1082.00
IUUC-Ssl-108508 Sclerotinia sclerotiorum 25.00 4.00e-09 57.00
IUUC-Ssc-116115 Sus scrofa 95.76 0.00e+00 1157.00
IUUC-Tgu-117005 Taeniopygia guttata 90.97 0.00e+00 1093.00
IUUC-Tsy-119510 Tarsius syrichta 87.63 0.00e+00 943.00
IUUC-Tre-122218 Trichoderma reesei 24.48 9.00e-12 65.90
IUUC-Tvi-122448 Trichoderma virens 24.17 3.00e-12 67.00
IUUC-Tme-126925 Tuber melanosporum 23.29 5.00e-09 56.60
IUUC-Ttr-128761 Tursiops truncatus 80.33 0.00e+00 957.00
IUUC-Vda-129874 Verticillium dahliae 24.50 1.00e-13 71.60
Created Date 25-Jun-2017

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