iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132592

UUCD1 version

UUC-XeT-00991

Ensembl Protein ID

ENSXETP00000063683.1

UniProt Accession

Q28F89; Q28GI1; UBE2S_XENTR

Genbank Protein ID

CAJ83662.1; CAJ82166.1; CAJ81686.1; AAI70651.1; AAI70653.1

Protein Name

Ubiquitin-conjugating enzyme E2 S; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S

Genbank Nucleotide ID

CR761031; CR761379; CR762108; BC170651; BC170653

Gene Name

ube2s; TEgg003m12.1; TEgg028l19.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000000138.3	ENSXETT00000064784.1	ENSXETP00000063683.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.20e-40	137.8	16	149

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeee 90
           ++ke+++l++dppegi++ p++e d+t+ +v i+Gpe+tpY+gg+F++++ + +d+P+ PPk  fltkifhPnv++nG++C+++lk  +
   Q: 16   VYKEVSTLTSDPPEGIKIIPNEE-DITDVQVNIEGPEGTPYAGGIFRMKLILGKDFPAAPPKGYFLTKIFHPNVSTNGEICVNVLK--K 101
           679********************.9************************************************************9..* PP
   S: 91   kWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +W++ l +++vll+i+ ll +pnpes+lneea +ll +n eey +++r
   Q: 102  DWKAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYASRAR 149
           *******************************************99986 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MNSNVENLPP HIIRQVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP EGTPYAGGIF 60
RMKLILGKDF PAAPPKGYFL TKIFHPNVST NGEICVNVLK KDWKAELGIR HVLLTIKCLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAACACCGT CACGGCGCTG AACAGTTCTC CTCCGTCCCC CGTTTGGCAC AGAGAGGCAT 60
GGTAAGTATC GGGGCTTTCC TGCTCTTATG GGGATCGGGG GAGGCGCAGT TCCACTGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:549192

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000818	Aegilops tauschii	67.55	1.00e-52	199.00
IUUC-Aml-001979	Ailuropoda melanoleuca	88.31	8.00e-82	296.00
IUUC-Atr-002706	Amborella trichopoda	65.56	9.00e-51	192.00
IUUC-Aca-004432	Anolis carolinensis	87.96	2.00e-97	347.00
IUUC-Aly-005779	Arabidopsis lyrata	63.69	5.00e-60	223.00
IUUC-Ath-007162	Arabidopsis thaliana	63.69	7.00e-60	223.00
IUUC-Acl-008107	Aspergillus clavatus	47.76	3.00e-34	139.00
IUUC-Afl-008578	Aspergillus flavus	43.93	9.00e-36	144.00
IUUC-Afu-009034	Aspergillus fumigatus	50.00	5.00e-35	141.00
IUUC-Ani-009151	Aspergillus nidulans	51.15	2.00e-36	146.00
IUUC-Ang-009649	Aspergillus niger	50.83	2.00e-35	143.00
IUUC-Ate-010468	Aspergillus terreus	59.55	3.00e-29	122.00
IUUC-Ame-010836	Astyanax mexicanus	64.61	4.00e-84	303.00
IUUC-Bta-012740	Bos taurus	88.39	4.00e-82	296.00
IUUC-Bdi-014601	Brachypodium distachyon	67.55	7.00e-53	200.00
IUUC-Bol-015087	Brassica oleracea	64.97	2.00e-60	225.00
IUUC-Bra-016867	Brassica rapa	64.97	8.00e-61	226.00
IUUC-Cja-019763	Callithrix jacchus	73.76	1.00e-84	305.00
IUUC-Cfa-020216	Canis familiaris	88.39	1.00e-82	298.00
IUUC-Cpo-021720	Cavia porcellus	78.76	2.00e-85	307.00
IUUC-Cre-022676	Chlamydomonas reinhardtii	58.94	6.00e-56	209.00
IUUC-Csa-023751	Chlorocebus sabaeus	73.76	2.00e-84	304.00
IUUC-Cho-024620	Choloepus hoffmanni	84.96	2.00e-57	213.00
IUUC-Cin-025632	Ciona intestinalis	61.14	3.00e-69	254.00
IUUC-Csv-025984	Ciona savignyi	67.31	2.00e-65	241.00
IUUC-Cne-026844	Cryptococcus neoformans	57.72	3.00e-50	191.00
IUUC-Cme-027294	Cyanidioschyzon merolae	45.95	8.00e-53	199.00
IUUC-Dre-027674	Danio rerio	66.09	3.00e-85	307.00
IUUC-Dno-029886	Dasypus novemcinctus	88.39	3.00e-82	297.00
IUUC-Dor-030440	Dipodomys ordii	74.38	3.00e-85	307.00
IUUC-Dse-031211	Dothistroma septosporum	45.38	1.00e-30	124.00
IUUC-Dme-031888	Drosophila melanogaster	63.30	4.00e-67	246.00
IUUC-Ete-032365	Echinops telfairi	70.52	4.00e-63	233.00
IUUC-Eca-033733	Equus caballus	87.74	1.00e-81	295.00
IUUC-Eeu-035342	Erinaceus europaeus	88.31	1.00e-80	291.00
IUUC-Gmo-039357	Gadus morhua	72.22	5.00e-80	290.00
IUUC-Gga-040261	Gallus gallus	59.09	3.00e-47	180.00
IUUC-Gac-042593	Gasterosteus aculeatus	72.82	8.00e-82	296.00
IUUC-Gma-043597	Glycine max	63.87	3.00e-61	228.00
IUUC-Ggo-044626	Gorilla gorilla	71.24	9.00e-59	218.00
IUUC-Hsa-046058	Homo sapiens	73.76	3.00e-84	303.00
IUUC-Hvu-047459	Hordeum vulgare	51.07	2.00e-52	198.00
IUUC-Itr-048739	Ictidomys tridecemlineatus	74.02	2.00e-85	308.00
IUUC-Lch-049415	Latimeria chalumnae	83.57	4.00e-65	239.00
IUUC-Lpe-050956	Leersia perrieri	54.97	2.00e-36	145.00
IUUC-Lma-052996	Leptosphaeria maculans	54.13	3.00e-33	135.00
IUUC-Laf-053337	Loxodonta africana	87.66	4.00e-81	293.00
IUUC-Mcc-055485	Macaca mulatta	65.64	3.00e-80	291.00
IUUC-Meu-056123	Macropus eugenii	88.31	4.00e-81	293.00
IUUC-Mtr-058300	Medicago truncatula	63.82	8.00e-59	219.00
IUUC-Mla-059060	Melampsora laricipopulina	55.19	1.00e-50	192.00
IUUC-Mmr-061005	Microcebus murinus	76.26	1.00e-82	298.00
IUUC-Mdo-062979	Monodelphis domestica	88.00	3.00e-65	240.00
IUUC-Mmu-063778	Mus musculus	76.12	3.00e-84	303.00
IUUC-Mac-064680	Musa acuminata	57.51	2.00e-61	229.00
IUUC-Mpu-065829	Mustela putorius furo	78.89	2.00e-83	301.00
IUUC-Mlu-067498	Myotis lucifugus	85.06	8.00e-75	272.00
IUUC-Nfi-068520	Neosartorya fischeri	50.00	6.00e-35	141.00
IUUC-Nle-069727	Nomascus leucogenys	72.12	1.00e-84	305.00
IUUC-Opr-071066	Ochotona princeps	85.09	2.00e-57	213.00
IUUC-Ont-072363	Oreochromis niloticus	72.82	3.00e-79	287.00
IUUC-Oan-073383	Ornithorhynchus anatinus	78.17	1.00e-59	221.00
IUUC-Ocu-074599	Oryctolagus cuniculus	88.72	1.00e-70	258.00
IUUC-Oba-075186	Oryza barthii	66.89	6.00e-54	204.00
IUUC-Obr-076104	Oryza brachyantha	66.89	2.00e-52	198.00
IUUC-Ogl-077835	Oryza glaberrima	66.89	5.00e-54	203.00
IUUC-Ogu-078690	Oryza glumaepatula	66.89	5.00e-54	203.00
IUUC-Oin-080215	Oryza indica	66.89	6.00e-54	204.00
IUUC-Olo-080816	Oryza longistaminata	66.89	5.00e-54	204.00
IUUC-Ome-081657	Oryza meridionalis	66.89	1.00e-53	203.00
IUUC-Oni-082601	Oryza nivara	66.89	5.00e-54	204.00
IUUC-Opu-083367	Oryza punctata	67.55	1.00e-53	202.00
IUUC-Oru-084477	Oryza rufipogon	66.89	5.00e-54	204.00
IUUC-Osa-086119	Oryza sativa	66.89	6.00e-54	203.00
IUUC-Ola-086702	Oryzias latipes	73.33	6.00e-82	296.00
IUUC-Olu-087576	Ostreococcus lucimarinus	54.90	5.00e-49	186.00
IUUC-Oga-088946	Otolemur garnettii	84.05	3.00e-82	297.00
IUUC-Oar-089564	Ovis aries	87.74	2.00e-81	294.00
IUUC-Ptr-090620	Pan troglodytes	73.63	1.00e-83	302.00
IUUC-Pan-092382	Papio anubis	65.64	3.00e-80	291.00
IUUC-Psi-093891	Pelodiscus sinensis	92.11	5.00e-61	225.00
IUUC-Pma-094344	Petromyzon marinus	83.66	8.00e-77	279.00
IUUC-Ppa-095452	Physcomitrella patens	48.56	6.00e-51	193.00
IUUC-Pfo-097288	Poecilia formosa	73.33	3.00e-82	297.00
IUUC-Pab-098506	Pongo abelii	73.63	9.00e-84	302.00
IUUC-Pop-098882	Populus trichocarpa	63.16	1.00e-59	222.00
IUUC-Pca-100749	Procavia capensis	73.08	5.00e-86	310.00
IUUC-Ppe-102084	Prunus persica	63.82	2.00e-59	222.00
IUUC-Pva-102755	Pteropus vampyrus	73.17	2.00e-85	307.00
IUUC-Pgr-103394	Puccinia graminis	53.90	2.00e-48	185.00
IUUC-Ptt-103750	Puccinia triticina	53.90	2.00e-48	185.00
IUUC-Pte-104240	Pyrenophora teres	41.77	2.00e-31	130.00
IUUC-Pyt-104483	Pyrenophora triticirepentis	41.77	4.00e-31	129.00
IUUC-Rno-105739	Rattus norvegicus	76.35	7.00e-88	316.00
IUUC-Smo-108939	Selaginella moellendorffii	55.93	3.00e-49	187.00
IUUC-Sit-109881	Setaria italica	66.23	3.00e-52	197.00
IUUC-Sly-111764	Solanum lycopersicum	54.36	1.00e-60	226.00
IUUC-Stu-111968	Solanum tuberosum	54.87	6.00e-61	227.00
IUUC-Sar-113093	Sorex araneus	59.69	2.00e-55	208.00
IUUC-Sbi-114015	Sorghum bicolor	48.59	4.00e-53	201.00
IUUC-Sre-115036	Sporisorium reilianum	45.27	2.00e-34	138.00
IUUC-Tru-117716	Takifugu rubripes	72.82	4.00e-82	296.00
IUUC-Tni-120210	Tetraodon nigroviridis	72.31	1.00e-81	295.00
IUUC-Tca-121315	Theobroma cacao	64.47	2.00e-60	225.00
IUUC-Tae-124474	Triticum aestivum	67.55	1.00e-52	199.00
IUUC-Tur-126669	Triticum urartu	67.55	2.00e-52	199.00
IUUC-Tme-127125	Tuber melanosporum	50.00	7.00e-40	157.00
IUUC-Tbe-128157	Tupaia belangeri	87.66	2.00e-81	294.00
IUUC-Ttr-128593	Tursiops truncatus	72.12	1.00e-83	302.00
IUUC-Uma-129592	Ustilago maydis	48.24	1.00e-41	162.00
IUUC-Vvi-131716	Vitis vinifera	64.24	8.00e-61	226.00
IUUC-Xma-133064	Xiphophorus maculatus	70.71	1.00e-73	269.00
IUUC-Yli-134575	Yarrowia lipolytica	44.91	4.00e-38	150.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence