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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063301
Ensembl Protein ID ENSMUSP00000043865.8
UniProt Accession Q8BGG7; Q3U8Z2; Q8BMW9; UBS3B_MOUSE
Genbank Protein ID BAD06450.1; BAC25403.1; BAC28714.1; BAC29178.1; BAE21945.1; BAE30779.1; BAE30875.1; BAE32688.1; AAH53436.1
Protein Name Ubiquitin-associated and SH3 domain-containing protein B; Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; Tyrosine-protein phosphatase STS1/TULA2
Genbank Nucleotide ID AB075602; AK013361; AK034450; AK035764; AK133948; AK151895; AK152013; AK154576; BC053436
Gene Name Ubash3b; Sts1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032020.15 ENSMUST00000044155.14 ENSMUSP00000043865.8
ENSMUSG00000032020.15 ENSMUST00000136530.7 ENSMUSP00000114176.1
ENSMUSG00000032020.15 ENSMUST00000129906.1 ENSMUSP00000134923.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 23784775
UBD/Alpha-Helix/UBA UBA 23784775
Classification
Family E-value Score Start End
UBD/SH3 2.00e-21 76.8 244 307
UBD/Alpha-Helix/UBA 1.20e-08 35.9 28 65
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++e++qv+y+y++qnddeL+l  Gd++++   e+++++egW++g++ ++g++Gl+Pen+++k++
   Q: 244  NHETLQVIYPYSPQNDDELELVPGDFIFMSpmEQTSTSEGWIYGTSLTTGCSGLLPENYITKAD 307
           6899*********************************************************987 PP
   

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++l+ l +MGF+r +a++aL+++ + +++aA+++L+++
   Q: 28   SALDVLLSMGFPRARAQKALASTgGRSVQAACDWLFSH 65
           68999*******************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
 Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
Protein Sequence
(Fasta)
MAAREELYSK VTPRRDRLQR PGTVKHGSAL DVLLSMGFPR ARAQKALAST GGRSVQAACD 60
WLFSHVGDPF LDDPLPREYV LYLRPTGPLA QKLSDFWQQS KQICGKNKAH NIFPHITLCQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063301|UBD,SH3;UBD,UBA|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCTCCAGT GTCGTGGGAT GACAGCCTAA GGGAAGCCCC ACATTCTGCC AGCTGAGGAA 60
ACTGAGCCTA GGACAGCAGC ACATGATGTC ACATGCACCA AGAACTCCCT TGGAGATTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063301|UBD,SH3;UBD,UBA|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50002--SH3
PS50030--UBA
Pfam

PF00300--His_Phos_1
PF14604--SH3_9
PF00627--UBA
SMART

SM00326--SH3
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0038065--P:collagen-activated signaling pathway
GO:0038063--P:collagen-activated tyrosine kinase receptor signaling pathway
GO:0045779--P:negative regulation of bone resorption
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0090331--P:negative regulation of platelet aggregation
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0030168--P:platelet activation
GO:0070527--P:platelet aggregation
GO:0045670--P:regulation of osteoclast differentiation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
KEGG mmu:72828
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002126 Ailuropoda melanoleuca 96.06 0.00e+00 1259.00
IUUC-Apl-004080 Anas platyrhynchos 90.45 0.00e+00 1107.00
IUUC-Aca-004828 Anolis carolinensis 84.08 0.00e+00 1044.00
IUUC-Ame-011030 Astyanax mexicanus 73.80 0.00e+00 829.00
IUUC-Bgr-012101 Blumeria graminis 29.85 7.00e-11 61.20
IUUC-Bta-012370 Bos taurus 96.81 0.00e+00 1191.00
IUUC-Bci-013728 Botrytis cinerea 27.71 2.00e-09 56.60
IUUC-Cel-018530 Caenorhabditis elegans 40.08 6.00e-52 197.00
IUUC-Cja-018758 Callithrix jacchus 97.49 0.00e+00 1258.00
IUUC-Cfa-020544 Canis familiaris 96.32 0.00e+00 1018.00
IUUC-Cpo-022044 Cavia porcellus 97.14 0.00e+00 1191.00
IUUC-Csa-024169 Chlorocebus sabaeus 97.49 0.00e+00 1257.00
IUUC-Cho-024498 Choloepus hoffmanni 79.83 0.00e+00 900.00
IUUC-Cin-025372 Ciona intestinalis 41.60 1.00e-58 221.00
IUUC-Csv-026379 Ciona savignyi 43.65 6.00e-75 274.00
IUUC-Cgl-026592 Colletotrichum gloeosporioides 29.59 3.00e-09 55.80
IUUC-Cme-027186 Cyanidioschyzon merolae 27.47 3.00e-08 52.40
IUUC-Dre-027539 Danio rerio 73.91 0.00e+00 1006.00
IUUC-Dno-029808 Dasypus novemcinctus 96.29 0.00e+00 748.00
IUUC-Dor-030582 Dipodomys ordii 80.72 0.00e+00 1009.00
IUUC-Dme-032201 Drosophila melanogaster 38.89 9.00e-66 245.00
IUUC-Ete-032740 Echinops telfairi 77.59 0.00e+00 1013.00
IUUC-Eca-033743 Equus caballus 97.35 0.00e+00 1211.00
IUUC-Eeu-034505 Erinaceus europaeus 85.20 0.00e+00 700.00
IUUC-Fca-036519 Felis catus 96.39 0.00e+00 1274.00
IUUC-Fal-037295 Ficedula albicollis 88.80 0.00e+00 1107.00
IUUC-Gmo-038650 Gadus morhua 72.27 0.00e+00 930.00
IUUC-Gga-040179 Gallus gallus 89.67 0.00e+00 1186.00
IUUC-Gac-042180 Gasterosteus aculeatus 72.14 0.00e+00 938.00
IUUC-Ggo-044581 Gorilla gorilla 97.81 0.00e+00 1261.00
IUUC-Hsa-046526 Homo sapiens 97.65 0.00e+00 1261.00
IUUC-Itr-048502 Ictidomys tridecemlineatus 95.90 0.00e+00 646.00
IUUC-Lch-049576 Latimeria chalumnae 80.56 0.00e+00 1016.00
IUUC-Loc-051854 Lepisosteus oculatus 79.03 0.00e+00 932.00
IUUC-Laf-054177 Loxodonta africana 96.55 0.00e+00 1269.00
IUUC-Mcc-055185 Macaca mulatta 97.65 0.00e+00 1260.00
IUUC-Meu-056216 Macropus eugenii 91.60 0.00e+00 1065.00
IUUC-Mga-059564 Meleagris gallopavo 90.44 0.00e+00 1110.00
IUUC-Mmr-060934 Microcebus murinus 97.96 0.00e+00 1262.00
IUUC-Mdo-062955 Monodelphis domestica 94.69 0.00e+00 1224.00
IUUC-Mpu-066416 Mustela putorius furo 96.71 0.00e+00 1275.00
IUUC-Mlu-067833 Myotis lucifugus 87.04 0.00e+00 1024.00
IUUC-Nle-069367 Nomascus leucogenys 97.18 0.00e+00 1253.00
IUUC-Opr-070879 Ochotona princeps 84.82 0.00e+00 754.00
IUUC-Ont-072540 Oreochromis niloticus 74.14 0.00e+00 957.00
IUUC-Oan-073124 Ornithorhynchus anatinus 91.21 0.00e+00 898.00
IUUC-Ocu-074796 Oryctolagus cuniculus 97.02 0.00e+00 1251.00
IUUC-Ola-087253 Oryzias latipes 72.67 0.00e+00 953.00
IUUC-Oga-088406 Otolemur garnettii 92.04 0.00e+00 1129.00
IUUC-Oar-090262 Ovis aries 96.71 0.00e+00 1251.00
IUUC-Ptr-091014 Pan troglodytes 97.81 0.00e+00 1261.00
IUUC-Pan-092684 Papio anubis 97.65 0.00e+00 1260.00
IUUC-Psi-093541 Pelodiscus sinensis 90.77 0.00e+00 1185.00
IUUC-Pma-094108 Petromyzon marinus 55.42 4.00e-152 531.00
IUUC-Pfo-097119 Poecilia formosa 72.12 0.00e+00 910.00
IUUC-Pab-097724 Pongo abelii 94.69 0.00e+00 1226.00
IUUC-Pca-100645 Procavia capensis 75.97 0.00e+00 724.00
IUUC-Pva-102322 Pteropus vampyrus 96.81 0.00e+00 1188.00
IUUC-Rno-105148 Rattus norvegicus 98.75 0.00e+00 1295.00
IUUC-Sha-106673 Sarcophilus harrisii 87.22 0.00e+00 1080.00
IUUC-Ssl-108385 Sclerotinia sclerotiorum 30.36 3.00e-08 52.40
IUUC-Sar-113746 Sorex araneus 76.99 4.00e-99 354.00
IUUC-Ssc-116425 Sus scrofa 97.35 0.00e+00 1212.00
IUUC-Tgu-116520 Taeniopygia guttata 88.73 0.00e+00 1153.00
IUUC-Tru-117750 Takifugu rubripes 67.57 0.00e+00 898.00
IUUC-Tsy-118975 Tarsius syrichta 96.81 0.00e+00 1166.00
IUUC-Tni-119830 Tetraodon nigroviridis 72.10 0.00e+00 913.00
IUUC-Tbe-127895 Tupaia belangeri 96.73 4.00e-133 468.00
IUUC-Ttr-129103 Tursiops truncatus 96.08 0.00e+00 1270.00
IUUC-Uma-129616 Ustilago maydis 24.39 7.00e-05 40.80
IUUC-Vpa-130720 Vicugna pacos 96.94 1.00e-112 400.00
IUUC-Xtr-132314 Xenopus tropicalis 82.66 0.00e+00 1106.00
Created Date 25-Jun-2017

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