iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037182

Ensembl Protein ID

ENSFALP00000006361.1

UniProt Accession

U3JUA7; U3JUA7_FICAL

Genbank Protein ID

ENSFALP00000006361

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01010985

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000006101.1	ENSFALT00000006390.1	ENSFALP00000006361.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.40e-08	32.9	365	404
UBD/Alpha-Helix/UBA	1.00e-05	25.2	730	763

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    + +s  + CP Cr
   Q: 365  CKICAENDKD-VKIEPCGHLMCTSCLTAW----Q-ESEGQGCPFCR 404
           99********.******************....5.555555****8 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyL 38
           + +e+l+++G++ +++++aL  a+nn+e+A + L
   Q: 730  SEIENLMSQGYSYQDIQKALVIAHNNIEMAKNIL 763
           679***************************9988 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MSAPLKKGPG GLIGLMKDAF QPHHHHLGPH QPGAVDKKMV EKCWKLMDKV VRLCQNPKLA 60
LKNSPPYILD LLPDTYQHLR TILSRYEGKM ETLGENEYFR VFMENLMKKT KQTISLFKEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GCGGCCCGGC CCGGCCCGGA GCGCCCTCAG 60
CCCGGTCCCC TCCAGGGCCG CGGCCCCGGT GCCGGACGGG CCCCGCGGGC CGGGTGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	96.21	0.00e+00	899.00
IUUC-Apl-004041	Anas platyrhynchos	98.89	0.00e+00	924.00
IUUC-Aca-004899	Anolis carolinensis	96.65	0.00e+00	878.00
IUUC-Bta-012759	Bos taurus	94.85	0.00e+00	937.00
IUUC-Cja-019207	Callithrix jacchus	94.50	0.00e+00	916.00
IUUC-Cfa-020897	Canis familiaris	95.67	0.00e+00	905.00
IUUC-Cpo-021453	Cavia porcellus	95.99	0.00e+00	901.00
IUUC-Csa-023136	Chlorocebus sabaeus	94.69	0.00e+00	916.00
IUUC-Cho-024282	Choloepus hoffmanni	80.50	0.00e+00	766.00
IUUC-Cin-025574	Ciona intestinalis	70.81	5.00e-178	617.00
IUUC-Csv-025938	Ciona savignyi	69.37	2.00e-172	597.00
IUUC-Dre-027644	Danio rerio	89.40	0.00e+00	836.00
IUUC-Dno-030025	Dasypus novemcinctus	97.09	0.00e+00	900.00
IUUC-Dme-032213	Drosophila melanogaster	74.23	0.00e+00	642.00
IUUC-Eca-033900	Equus caballus	96.66	0.00e+00	903.00
IUUC-Eeu-035142	Erinaceus europaeus	84.72	0.00e+00	763.00
IUUC-Fca-035455	Felis catus	95.68	0.00e+00	944.00
IUUC-Gmo-038698	Gadus morhua	90.40	0.00e+00	877.00
IUUC-Gga-040438	Gallus gallus	99.37	0.00e+00	951.00
IUUC-Gac-042166	Gasterosteus aculeatus	89.60	0.00e+00	843.00
IUUC-Ggo-045618	Gorilla gorilla	94.89	0.00e+00	917.00
IUUC-Hsa-046177	Homo sapiens	94.89	0.00e+00	917.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	96.77	0.00e+00	746.00
IUUC-Lch-050095	Latimeria chalumnae	90.58	0.00e+00	879.00
IUUC-Loc-052570	Lepisosteus oculatus	90.45	0.00e+00	867.00
IUUC-Laf-054008	Loxodonta africana	94.47	0.00e+00	934.00
IUUC-Mcc-054676	Macaca mulatta	94.69	0.00e+00	916.00
IUUC-Mga-059239	Meleagris gallopavo	98.98	0.00e+00	980.00
IUUC-Mmr-060907	Microcebus murinus	95.08	0.00e+00	947.00
IUUC-Mdo-062595	Monodelphis domestica	97.74	0.00e+00	869.00
IUUC-Mmu-063725	Mus musculus	94.85	0.00e+00	941.00
IUUC-Mpu-066771	Mustela putorius furo	94.89	0.00e+00	946.00
IUUC-Mlu-067206	Myotis lucifugus	96.88	0.00e+00	836.00
IUUC-Nle-069285	Nomascus leucogenys	94.89	0.00e+00	916.00
IUUC-Opr-071026	Ochotona princeps	96.85	0.00e+00	897.00
IUUC-Ont-071954	Oreochromis niloticus	90.75	0.00e+00	853.00
IUUC-Ocu-074657	Oryctolagus cuniculus	95.99	0.00e+00	899.00
IUUC-Ola-087165	Oryzias latipes	89.57	0.00e+00	851.00
IUUC-Oga-088198	Otolemur garnettii	96.03	0.00e+00	886.00
IUUC-Oar-090258	Ovis aries	96.65	0.00e+00	900.00
IUUC-Ptr-090710	Pan troglodytes	94.89	0.00e+00	917.00
IUUC-Pan-092785	Papio anubis	94.69	0.00e+00	916.00
IUUC-Pfo-096990	Poecilia formosa	90.29	0.00e+00	830.00
IUUC-Pab-098526	Pongo abelii	94.88	0.00e+00	918.00
IUUC-Pva-102352	Pteropus vampyrus	95.15	0.00e+00	879.00
IUUC-Rno-105876	Rattus norvegicus	94.86	0.00e+00	939.00
IUUC-Sha-107588	Sarcophilus harrisii	97.06	0.00e+00	792.00
IUUC-Sar-112959	Sorex araneus	96.65	0.00e+00	902.00
IUUC-Ssc-115261	Sus scrofa	95.26	0.00e+00	943.00
IUUC-Tgu-116580	Taeniopygia guttata	100.00	0.00e+00	931.00
IUUC-Tru-118731	Takifugu rubripes	88.56	0.00e+00	836.00
IUUC-Tni-119861	Tetraodon nigroviridis	91.33	0.00e+00	810.00
IUUC-Tbe-128018	Tupaia belangeri	96.85	0.00e+00	902.00
IUUC-Ttr-128927	Tursiops truncatus	94.93	0.00e+00	954.00
IUUC-Vpa-130369	Vicugna pacos	96.43	0.00e+00	897.00
IUUC-Xtr-132474	Xenopus tropicalis	89.96	0.00e+00	896.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence