iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121046

Ensembl Protein ID

EOY14903

UniProt Accession

A0A061FDA8; A0A061FDA8_THECC

Genbank Protein ID

EOY14903.1

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

CM001886

Gene Name

TCM_034144

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_034144	EOY14903	EOY14903

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.00e-37	125.5	50	85
UBD/Beta-Prp	3.50e-77	260.5	3	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           H ++v++++f  s +l+vsG+dD +ikvW+++ +++
   Q: 50   HDGPVRGVHFhkSQPLFVSGGDDYKIKVWNYKLHRC 85
           99*********7559***************876666 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           t +++++++++ + f+ ++++++++  +g i++wd+++g+l+ ++ +h+++v+ v f+++++++v+g++D+ ikvw+++   c+ tl gh d++++++f+ 
   Q: 3    TKFETKSNRVKGLSFHSKRPWILASLHSGVIQLWDYRMGTLIDRFDEHDGPVRGVHFHKSQPLFVSGGDDYKIKVWNYKLHRCLFTLLGHLDYIRTVQFHH 103
           67889999********************************************************************************************* PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.............................ktgkllrtl. 175
           +  ++vs+s+d+tir+w++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                                       
   Q: 104  EYPWIVSASDDQTIRIWNWQSRTCIA-VLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIgalkkktvapaddilrlgqlsqmntdffgG-------Vd 196
           **************************.**************************************************999666666666662.......04 PP
   S: 176  .......tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
                  +g h++ v++ sf+++ + +vsg++d++vklw +  ++   v+t++gh +nv++v f+++++++vs s+D+sir+Wd ++++ l+t+ ++++++
   Q: 197  avvkyvlEG-HDRGVNWASFHPTLPLIVSGADDRQVKLWRMNDTKAweVDTMRGHMNNVSCVLFHSRQDIIVSNSEDKSIRVWDATKRTGLQTFRREHDRF 296
           444444265.********************************777668***************************************************** PP
   S: 268  isvavlsfgdnvlvlgsedskvniwklkknep 299
           +  a+ +++ n +++g  ds   ++kl++++p
   Q: 297  WILAC-HPEMNLMAAG-HDSGMIVFKLERERP 326
           *****.8888777766.678999999988765 PP

Organism

Theobroma cacao

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSN RVKGLSFHSK RPWILASLHS GVIQLWDYRM GTLIDRFDEH DGPVRGVHFH 60
KSQPLFVSGG DDYKIKVWNY KLHRCLFTLL GHLDYIRTVQ FHHEYPWIVS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACGTGTT GGATGTGTCT TATTCCGAAA ATTCCATTAC CGAAAAAATG AAAATTAATG 60
TCCTCACTTG GAAATTACTA AAAAGTAGAA CTGGAAAAAG AAAAAAGAAA AACAGGAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001758	Ailuropoda melanoleuca	54.37	0.00e+00	1364.00
IUUC-Ago-007992	Ashbya gossypii	43.11	0.00e+00	974.00
IUUC-Acl-008027	Aspergillus clavatus	47.84	0.00e+00	1119.00
IUUC-Afl-008644	Aspergillus flavus	47.89	0.00e+00	1114.00
IUUC-Ang-009756	Aspergillus niger	47.76	0.00e+00	1129.00
IUUC-Aor-010174	Aspergillus oryzae	47.89	0.00e+00	1115.00
IUUC-Ate-010302	Aspergillus terreus	48.29	0.00e+00	1155.00
IUUC-Ame-011229	Astyanax mexicanus	54.21	0.00e+00	1325.00
IUUC-Bgr-012300	Blumeria graminis	46.70	0.00e+00	1072.00
IUUC-Bta-012524	Bos taurus	54.85	0.00e+00	1358.00
IUUC-Cja-019107	Callithrix jacchus	54.09	0.00e+00	1346.00
IUUC-Cfa-020675	Canis familiaris	54.03	0.00e+00	1336.00
IUUC-Cpo-021813	Cavia porcellus	54.93	0.00e+00	1375.00
IUUC-Csa-023523	Chlorocebus sabaeus	55.01	0.00e+00	1381.00
IUUC-Cho-024704	Choloepus hoffmanni	42.21	8.00e-175	607.00
IUUC-Cin-025572	Ciona intestinalis	51.25	0.00e+00	1258.00
IUUC-Cne-027053	Cryptococcus neoformans	50.81	0.00e+00	1179.00
IUUC-Dre-027421	Danio rerio	54.83	0.00e+00	1358.00
IUUC-Dno-029303	Dasypus novemcinctus	54.93	0.00e+00	1379.00
IUUC-Dor-030290	Dipodomys ordii	52.89	2.00e-165	575.00
IUUC-Eca-033773	Equus caballus	53.98	0.00e+00	1338.00
IUUC-Fca-035739	Felis catus	54.10	0.00e+00	1337.00
IUUC-Gmo-039602	Gadus morhua	51.41	0.00e+00	1233.00
IUUC-Gga-040590	Gallus gallus	55.09	0.00e+00	1373.00
IUUC-Gac-041318	Gasterosteus aculeatus	54.58	0.00e+00	1348.00
IUUC-Ggo-045029	Gorilla gorilla	54.61	0.00e+00	1373.00
IUUC-Hsa-046078	Homo sapiens	54.53	0.00e+00	1371.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	46.04	0.00e+00	765.00
IUUC-Lch-049706	Latimeria chalumnae	55.14	0.00e+00	1363.00
IUUC-Mcc-055836	Macaca mulatta	54.54	0.00e+00	1367.00
IUUC-Mor-057172	Magnaporthe oryzae	47.32	0.00e+00	1105.00
IUUC-Mla-059019	Melampsora laricipopulina	50.36	0.00e+00	1215.00
IUUC-Mga-059499	Meleagris gallopavo	55.08	0.00e+00	1370.00
IUUC-Mmr-061102	Microcebus murinus	54.45	0.00e+00	1359.00
IUUC-Mdo-062594	Monodelphis domestica	55.41	0.00e+00	1403.00
IUUC-Mmu-063736	Mus musculus	54.48	0.00e+00	1363.00
IUUC-Mpu-066701	Mustela putorius furo	55.01	0.00e+00	1373.00
IUUC-Mlu-067392	Myotis lucifugus	54.85	0.00e+00	1360.00
IUUC-Ont-072488	Oreochromis niloticus	54.29	0.00e+00	1341.00
IUUC-Ocu-074211	Oryctolagus cuniculus	54.85	0.00e+00	1371.00
IUUC-Obr-076429	Oryza brachyantha	77.45	0.00e+00	1967.00
IUUC-Oga-087991	Otolemur garnettii	51.78	0.00e+00	1273.00
IUUC-Oar-089590	Ovis aries	54.77	0.00e+00	1374.00
IUUC-Ptr-090808	Pan troglodytes	54.61	0.00e+00	1373.00
IUUC-Pan-092475	Papio anubis	54.72	0.00e+00	1372.00
IUUC-Pno-094839	Phaeosphaeria nodorum	46.28	0.00e+00	1040.00
IUUC-Pab-098497	Pongo abelii	54.93	0.00e+00	1381.00
IUUC-Pca-100413	Procavia capensis	61.18	0.00e+00	700.00
IUUC-Ppe-101392	Prunus persica	89.43	0.00e+00	2247.00
IUUC-Pva-102126	Pteropus vampyrus	52.29	0.00e+00	1293.00
IUUC-Pgr-103376	Puccinia graminis	51.46	0.00e+00	1231.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	46.05	1.00e-174	606.00
IUUC-Rno-105428	Rattus norvegicus	54.68	0.00e+00	1371.00
IUUC-Sce-106464	Saccharomyces cerevisiae	42.18	0.00e+00	947.00
IUUC-Sha-107301	Sarcophilus harrisii	54.37	0.00e+00	1357.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.74	0.00e+00	1074.00
IUUC-Spo-108217	Schizosaccharomyces pombe	45.11	0.00e+00	1060.00
IUUC-Sly-111447	Solanum lycopersicum	83.63	0.00e+00	2145.00
IUUC-Stu-112564	Solanum tuberosum	84.28	0.00e+00	2137.00
IUUC-Sar-113313	Sorex araneus	42.07	0.00e+00	643.00
IUUC-Sre-115209	Sporisorium reilianum	55.79	0.00e+00	999.00
IUUC-Ssc-115933	Sus scrofa	54.85	0.00e+00	1374.00
IUUC-Tgu-117109	Taeniopygia guttata	44.59	3.00e-113	401.00
IUUC-Tru-117772	Takifugu rubripes	53.63	0.00e+00	1317.00
IUUC-Tni-120556	Tetraodon nigroviridis	41.81	0.00e+00	886.00
IUUC-Tre-121951	Trichoderma reesei	46.55	0.00e+00	1087.00
IUUC-Tme-127170	Tuber melanosporum	48.17	0.00e+00	1169.00
IUUC-Ttr-128217	Tursiops truncatus	52.69	0.00e+00	1299.00
IUUC-Vpa-130537	Vicugna pacos	54.33	0.00e+00	1345.00
IUUC-Vvi-130958	Vitis vinifera	88.03	0.00e+00	2182.00
IUUC-Xtr-132857	Xenopus tropicalis	52.94	0.00e+00	1286.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence