iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.00e-26	90.8	1355	1408

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1355 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1408
           58********************************.*****99999*******876 PP

Organism

Rattus norvegicus

Functional Description
(View)

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.

Protein Sequence
(Fasta)

DEQFLGFGSD EEVRVRSPTR SPSVKASPRK PRGRPRSGSD RNPAILSDPS VFSPLNKSET 60
KSTDKIKKKD SKSIEKKRGR PPTFPGVKIK ITHGKDIAEL TQGSKEDSLK KVKRTPSAMF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGAGCAGT TCTTAGGTTT TGGCTCAGAT GAAGAAGTCA GAGTGCGAAG CCCCACCAGG 60
TCTCCTTCAG GTATGGCCAA TGAAGCATGT GTCGCAGATC TGCCTTCTGT CTGTGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0051899--P:membrane depolarization
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0035864--P:response to potassium ion
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	1.00e-12	68.60
IUUC-Aml-002274	Ailuropoda melanoleuca	90.55	0.00e+00	5744.00
IUUC-Atr-002455	Amborella trichopoda	48.10	8.00e-39	155.00
IUUC-Apl-003478	Anas platyrhynchos	77.75	0.00e+00	3855.00
IUUC-Aca-005086	Anolis carolinensis	79.48	0.00e+00	1455.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	4.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	5.00e-37	150.00
IUUC-Bta-012974	Bos taurus	89.48	0.00e+00	5645.00
IUUC-Bol-016540	Brassica oleracea	48.05	1.00e-37	151.00
IUUC-Cja-019226	Callithrix jacchus	88.64	0.00e+00	5657.00
IUUC-Cfa-021049	Canis familiaris	90.47	0.00e+00	5740.00
IUUC-Cpo-021459	Cavia porcellus	89.71	0.00e+00	4122.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	2.00e-38	155.00
IUUC-Csa-023434	Chlorocebus sabaeus	89.47	0.00e+00	4143.00
IUUC-Cho-024652	Choloepus hoffmanni	85.33	0.00e+00	3680.00
IUUC-Cin-025724	Ciona intestinalis	54.46	5.00e-96	346.00
IUUC-Csv-026268	Ciona savignyi	36.79	2.00e-132	468.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	5.00e-12	67.00
IUUC-Dre-028180	Danio rerio	68.35	0.00e+00	1134.00
IUUC-Dno-029068	Dasypus novemcinctus	86.07	0.00e+00	5384.00
IUUC-Dor-030550	Dipodomys ordii	84.78	0.00e+00	4913.00
IUUC-Ete-032834	Echinops telfairi	80.49	0.00e+00	2600.00
IUUC-Eca-033615	Equus caballus	90.28	0.00e+00	5599.00
IUUC-Eeu-035136	Erinaceus europaeus	79.34	0.00e+00	1112.00
IUUC-Fca-036453	Felis catus	86.37	0.00e+00	2478.00
IUUC-Fal-037256	Ficedula albicollis	77.50	0.00e+00	4841.00
IUUC-Gmo-038641	Gadus morhua	67.12	0.00e+00	1078.00
IUUC-Gga-040828	Gallus gallus	77.15	0.00e+00	4742.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.77	0.00e+00	1145.00
IUUC-Gma-043554	Glycine max	49.02	4.00e-38	153.00
IUUC-Ggo-045124	Gorilla gorilla	85.72	0.00e+00	3872.00
IUUC-Hsa-046143	Homo sapiens	89.35	0.00e+00	4106.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	88.61	0.00e+00	4964.00
IUUC-Lch-049704	Latimeria chalumnae	62.99	0.00e+00	860.00
IUUC-Loc-052181	Lepisosteus oculatus	77.88	0.00e+00	1298.00
IUUC-Laf-053946	Loxodonta africana	89.33	0.00e+00	5483.00
IUUC-Mcc-055508	Macaca mulatta	89.61	0.00e+00	4132.00
IUUC-Meu-056485	Macropus eugenii	79.56	0.00e+00	2426.00
IUUC-Mtr-058327	Medicago truncatula	41.52	1.00e-38	155.00
IUUC-Mga-059943	Meleagris gallopavo	75.16	0.00e+00	4416.00
IUUC-Mmr-061178	Microcebus murinus	88.86	0.00e+00	4187.00
IUUC-Mdo-063031	Monodelphis domestica	83.55	0.00e+00	3855.00
IUUC-Mmu-063650	Mus musculus	96.31	0.00e+00	4509.00
IUUC-Mpu-066495	Mustela putorius furo	90.26	0.00e+00	3875.00
IUUC-Mlu-068045	Myotis lucifugus	82.51	0.00e+00	5133.00
IUUC-Nle-069064	Nomascus leucogenys	90.35	0.00e+00	5696.00
IUUC-Opr-071043	Ochotona princeps	83.08	0.00e+00	4109.00
IUUC-Ont-072556	Oreochromis niloticus	69.83	0.00e+00	1117.00
IUUC-Oan-073324	Ornithorhynchus anatinus	75.12	0.00e+00	2077.00
IUUC-Ocu-074190	Oryctolagus cuniculus	88.42	0.00e+00	5534.00
IUUC-Oba-075647	Oryza barthii	49.36	3.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.71	1.00e-35	145.00
IUUC-Ome-081214	Oryza meridionalis	49.36	3.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.36	3.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	49.36	3.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	49.36	3.00e-38	154.00
IUUC-Ola-087176	Oryzias latipes	64.55	0.00e+00	1123.00
IUUC-Olu-087718	Ostreococcus lucimarinus	37.50	1.00e-35	146.00
IUUC-Oga-088208	Otolemur garnettii	89.95	0.00e+00	5579.00
IUUC-Oar-090152	Ovis aries	89.56	0.00e+00	5717.00
IUUC-Ptr-091127	Pan troglodytes	89.35	0.00e+00	4079.00
IUUC-Pan-092679	Papio anubis	89.58	0.00e+00	4112.00
IUUC-Psi-094059	Pelodiscus sinensis	77.72	0.00e+00	4831.00
IUUC-Pma-094258	Petromyzon marinus	59.80	0.00e+00	676.00
IUUC-Pfo-096536	Poecilia formosa	68.16	0.00e+00	1106.00
IUUC-Pab-098262	Pongo abelii	90.09	0.00e+00	5665.00
IUUC-Pca-100358	Procavia capensis	85.09	0.00e+00	5187.00
IUUC-Pva-102522	Pteropus vampyrus	84.08	0.00e+00	4447.00
IUUC-Sha-107174	Sarcophilus harrisii	82.41	0.00e+00	5144.00
IUUC-Smo-109164	Selaginella moellendorffii	51.95	1.00e-40	162.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	6.00e-36	146.00
IUUC-Stu-112529	Solanum tuberosum	48.37	2.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	80.21	0.00e+00	2939.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	9.00e-11	62.40
IUUC-Tgu-117047	Taeniopygia guttata	77.82	0.00e+00	4781.00
IUUC-Tsy-118953	Tarsius syrichta	83.65	0.00e+00	2830.00
IUUC-Tni-120837	Tetraodon nigroviridis	65.60	0.00e+00	1124.00
IUUC-Tbe-127950	Tupaia belangeri	83.91	0.00e+00	2704.00
IUUC-Ttr-128643	Tursiops truncatus	87.97	0.00e+00	5467.00
IUUC-Vpa-130660	Vicugna pacos	85.21	0.00e+00	1903.00
IUUC-Vvi-131476	Vitis vinifera	46.75	3.00e-39	157.00
IUUC-Xtr-132869	Xenopus tropicalis	64.46	0.00e+00	2201.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence