iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033921

UUCD1 version

UUC-EqC-00127

Ensembl Protein ID

ENSECAP00000015683.1

UniProt Accession

F6RQW3; F6RQW3_HORSE

Protein Name

Uncharacterized protein

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000018127.1	ENSECAT00000019176.1	ENSECAP00000015683.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.80e-06	27.2	349	388

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 349  CKICAESNKD-VKIEPCGHLLCSRCLAAW-----QHSDSQTCPFCR 388
           99********.******************.....6889999****8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MAAAAAPRGR QRGEPRALGR AVRLLQRLEE RCGDPRLSSS PPSLRDLLPR TAQLLRDVAQ 60
TRRTAGGGDP EGPGGAGDFL VVYLANLEAK SRQVAELLPP RGREANDELF REGSRLRRQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGCGG CAGCGGCCCC GCGGGGGCGA CAGCGGGGAG AGCCTCGCGC GCTCGGCCGG 60
GCGGTGAGGT TGCTGCAGCG CCTGGAGGAG CGGTGCGGGG ACCCGCGACT CTCCTCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	75.40	3.00e-180	624.00
IUUC-Bta-012705	Bos taurus	74.85	3.00e-178	618.00
IUUC-Cja-019179	Callithrix jacchus	75.00	2.00e-173	602.00
IUUC-Cfa-020593	Canis familiaris	71.49	4.00e-172	597.00
IUUC-Cpo-021289	Cavia porcellus	69.03	9.00e-151	526.00
IUUC-Csa-023966	Chlorocebus sabaeus	71.86	5.00e-167	580.00
IUUC-Dor-030246	Dipodomys ordii	68.18	1.00e-100	359.00
IUUC-Fca-035747	Felis catus	60.32	3.00e-144	504.00
IUUC-Ggo-044622	Gorilla gorilla	73.67	2.00e-130	458.00
IUUC-Hsa-045735	Homo sapiens	75.69	4.00e-174	603.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	73.76	2.00e-156	545.00
IUUC-Laf-053983	Loxodonta africana	73.96	0.00e+00	638.00
IUUC-Mmr-061310	Microcebus murinus	71.90	4.00e-166	577.00
IUUC-Mmu-064155	Mus musculus	67.74	2.00e-168	585.00
IUUC-Mpu-066655	Mustela putorius furo	70.49	8.00e-174	603.00
IUUC-Mlu-067929	Myotis lucifugus	72.28	3.00e-124	437.00
IUUC-Nle-070065	Nomascus leucogenys	63.53	1.00e-130	459.00
IUUC-Oga-087952	Otolemur garnettii	74.46	0.00e+00	626.00
IUUC-Oar-089382	Ovis aries	73.64	6.00e-166	577.00
IUUC-Ptr-090579	Pan troglodytes	60.19	4.00e-130	457.00
IUUC-Pan-092075	Papio anubis	74.88	4.00e-162	564.00
IUUC-Pab-098100	Pongo abelii	66.51	3.00e-143	501.00
IUUC-Pca-100830	Procavia capensis	67.84	2.00e-80	293.00
IUUC-Pva-102714	Pteropus vampyrus	69.21	3.00e-134	471.00
IUUC-Rno-105348	Rattus norvegicus	67.07	5.00e-168	583.00
IUUC-Ssc-116424	Sus scrofa	73.31	0.00e+00	647.00
IUUC-Tbe-128055	Tupaia belangeri	81.31	1.00e-103	370.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence