iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069178

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Breast cancer type 1 susceptibility protein homolog

Genbank Nucleotide ID

ADFV01118377

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000011944.2	ENSNLET00000015362.1	ENSNLEP00000014631.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.70e-08	32.6	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP

Organism

Nomascus leucogenys

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDLSAVRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII CAFQLDTGLQ YANSYNFAKK ENNSPEHLKD 120

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Nucleotide Sequence
(Fasta)

GTACCTTGAT TTCGTATTCT GAGAGGCTGT TGCTTAGCGG TAGCCCCCTG GTTTCCGTGG 60
CAACGGAAAA GCGCGGGAAT TACAGATAAA TTAAAACTGC GACTGCGCGG CGTGAGCTCG 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007059--P:chromosome segregation
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	74.60	0.00e+00	2657.00
IUUC-Apl-003252	Anas platyrhynchos	36.50	1.00e-132	468.00
IUUC-Aca-004526	Anolis carolinensis	54.55	1.00e-76	281.00
IUUC-Ame-011720	Astyanax mexicanus	47.29	3.00e-52	201.00
IUUC-Bta-013433	Bos taurus	72.00	0.00e+00	2506.00
IUUC-Cel-018208	Caenorhabditis elegans	33.70	2.00e-10	60.50
IUUC-Cja-019149	Callithrix jacchus	87.79	0.00e+00	3165.00
IUUC-Cfa-020322	Canis familiaris	74.15	0.00e+00	2603.00
IUUC-Cpo-021583	Cavia porcellus	47.09	0.00e+00	1368.00
IUUC-Csa-024227	Chlorocebus sabaeus	92.66	0.00e+00	691.00
IUUC-Cho-024530	Choloepus hoffmanni	68.99	0.00e+00	1196.00
IUUC-Cin-025364	Ciona intestinalis	42.86	1.00e-14	73.60
IUUC-Csv-026245	Ciona savignyi	38.46	2.00e-13	68.90
IUUC-Dno-029247	Dasypus novemcinctus	71.28	0.00e+00	2063.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	7.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	55.90	0.00e+00	1722.00
IUUC-Eca-033446	Equus caballus	76.73	0.00e+00	2775.00
IUUC-Eeu-034858	Erinaceus europaeus	61.06	0.00e+00	972.00
IUUC-Fca-035991	Felis catus	75.28	0.00e+00	2695.00
IUUC-Fal-036803	Ficedula albicollis	31.11	2.00e-103	371.00
IUUC-Gmo-038782	Gadus morhua	44.79	8.00e-45	176.00
IUUC-Ggr-039833	Gaeumannomyces graminis	36.73	1.00e-07	51.20
IUUC-Gga-040969	Gallus gallus	51.81	1.00e-79	292.00
IUUC-Gac-042296	Gasterosteus aculeatus	44.98	3.00e-50	194.00
IUUC-Ggo-044740	Gorilla gorilla	91.56	0.00e+00	3262.00
IUUC-Hsa-046086	Homo sapiens	95.92	0.00e+00	3414.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	74.35	0.00e+00	2700.00
IUUC-Lch-049789	Latimeria chalumnae	37.40	1.00e-95	345.00
IUUC-Loc-051952	Lepisosteus oculatus	52.73	5.00e-68	253.00
IUUC-Laf-053648	Loxodonta africana	73.70	0.00e+00	2504.00
IUUC-Mcc-055210	Macaca mulatta	92.04	0.00e+00	3364.00
IUUC-Meu-056342	Macropus eugenii	39.39	3.00e-130	460.00
IUUC-Mor-057034	Magnaporthe oryzae	38.78	3.00e-08	53.10
IUUC-Mga-060163	Meleagris gallopavo	54.34	1.00e-82	302.00
IUUC-Mmr-061402	Microcebus murinus	72.45	0.00e+00	843.00
IUUC-Mdo-062209	Monodelphis domestica	45.44	0.00e+00	1269.00
IUUC-Mmu-064003	Mus musculus	56.04	0.00e+00	1825.00
IUUC-Mpu-065825	Mustela putorius furo	78.83	0.00e+00	819.00
IUUC-Mlu-068176	Myotis lucifugus	72.09	0.00e+00	2370.00
IUUC-Opr-070574	Ochotona princeps	60.74	0.00e+00	1968.00
IUUC-Ont-072380	Oreochromis niloticus	47.57	5.00e-56	213.00
IUUC-Oan-073243	Ornithorhynchus anatinus	76.19	7.00e-35	139.00
IUUC-Ocu-074424	Oryctolagus cuniculus	69.10	0.00e+00	2362.00
IUUC-Ola-086863	Oryzias latipes	47.80	2.00e-53	204.00
IUUC-Oar-089938	Ovis aries	72.28	0.00e+00	2565.00
IUUC-Ptr-090960	Pan troglodytes	96.67	0.00e+00	3469.00
IUUC-Pan-092609	Papio anubis	92.46	0.00e+00	2991.00
IUUC-Psi-093889	Pelodiscus sinensis	31.46	1.00e-56	215.00
IUUC-Pfo-096328	Poecilia formosa	50.23	7.00e-59	223.00
IUUC-Pab-097982	Pongo abelii	96.40	0.00e+00	3498.00
IUUC-Pca-100698	Procavia capensis	66.18	0.00e+00	691.00
IUUC-Pva-102631	Pteropus vampyrus	77.70	0.00e+00	1179.00
IUUC-Rno-105879	Rattus norvegicus	56.04	0.00e+00	1800.00
IUUC-Sha-106701	Sarcophilus harrisii	38.69	0.00e+00	670.00
IUUC-Spo-108335	Schizosaccharomyces pombe	32.58	2.00e-09	57.40
IUUC-Sar-113047	Sorex araneus	64.01	0.00e+00	1520.00
IUUC-Ssc-115846	Sus scrofa	74.10	0.00e+00	2633.00
IUUC-Tgu-116785	Taeniopygia guttata	30.18	1.00e-93	338.00
IUUC-Tru-117895	Takifugu rubripes	39.64	2.00e-53	204.00
IUUC-Tsy-118885	Tarsius syrichta	60.57	0.00e+00	730.00
IUUC-Tni-119654	Tetraodon nigroviridis	45.15	3.00e-49	191.00
IUUC-Tbe-127421	Tupaia belangeri	62.69	1.00e-162	567.00
IUUC-Ttr-128685	Tursiops truncatus	75.54	0.00e+00	2532.00
IUUC-Vpa-130216	Vicugna pacos	72.23	0.00e+00	884.00
IUUC-Xtr-132398	Xenopus tropicalis	39.92	1.00e-39	159.00
IUUC-Xma-133651	Xiphophorus maculatus	51.76	8.00e-45	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence