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Tag Content
UUCD2 ID IUUC-Laf-053483
UUCD1 version UUC-LoA-00208
Ensembl Protein ID ENSLAFP00000004935.3
UniProt Accession G3SX30; G3SX30_LOXAF
Protein Name Uncharacterized protein
Gene Name MDM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000005885.3 ENSLAFT00000005885.3 ENSLAFP00000004935.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 85.57 0.00e+00 737.00 IUUC-Hsa-046376
E3 activity/RING/RING 75.86 0.00e+00 633.00 IUUC-Mmu-063207
E3 activity/RING/RING 77.19 0.00e+00 644.00 IUUC-Rno-105641
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Loxodonta africana
Protein Sequence
(Fasta)
MCNTNMSVST TDGAAASTSQ IPASEQETLV RPKPLLLKLL KSVGAQKDTY TMKEVIFYLG 60
QYIMAKRLYD EKQQHMVYCS NDLLGDLFGE PSFSVKDHRK IYTMIYRNLV VVNQQEPLDS 120
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Protein Fasta Sequence



>IUUC-Laf-053483|E3,RING|Loxodonta africana
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Nucleotide Sequence
(Fasta)
ATGTGCAACA CCAACATGTC TGTGTCTACA ACCGATGGTG CTGCTGCAAG CACCTCACAG 60
ATTCCTGCTT CAGAACAAGA GACCCTGGTT GGTATTTTTG TCTCAAGTGT AACATCGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Laf-053483|E3,RING|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

KEGG lav:100669448
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002039 Ailuropoda melanoleuca 86.99 0.00e+00 759.00
IUUC-Apl-003193 Anas platyrhynchos 63.16 2.00e-148 518.00
IUUC-Aca-004305 Anolis carolinensis 56.74 4.00e-117 414.00
IUUC-Ame-010675 Astyanax mexicanus 42.54 1.00e-80 293.00
IUUC-Bta-013270 Bos taurus 85.80 0.00e+00 731.00
IUUC-Cja-019744 Callithrix jacchus 85.83 0.00e+00 734.00
IUUC-Cfa-020807 Canis familiaris 85.56 0.00e+00 684.00
IUUC-Cpo-022182 Cavia porcellus 81.50 0.00e+00 694.00
IUUC-Csa-023541 Chlorocebus sabaeus 84.96 0.00e+00 748.00
IUUC-Cho-024831 Choloepus hoffmanni 72.63 3.00e-84 304.00
IUUC-Csv-026151 Ciona savignyi 30.14 4.00e-10 58.20
IUUC-Dre-028419 Danio rerio 42.03 3.00e-67 249.00
IUUC-Dno-028950 Dasypus novemcinctus 86.18 0.00e+00 776.00
IUUC-Dor-031048 Dipodomys ordii 66.60 3.00e-158 551.00
IUUC-Ete-032264 Echinops telfairi 75.25 0.00e+00 660.00
IUUC-Eca-033301 Equus caballus 78.05 0.00e+00 686.00
IUUC-Eeu-035005 Erinaceus europaeus 73.98 2.00e-169 588.00
IUUC-Fca-035454 Felis catus 87.60 0.00e+00 738.00
IUUC-Fal-036720 Ficedula albicollis 60.73 1.00e-71 262.00
IUUC-Fox-037963 Fusarium oxysporum 20.42 6.00e-02 32.70
IUUC-Gmo-039296 Gadus morhua 42.59 9.00e-44 170.00
IUUC-Gga-040251 Gallus gallus 64.17 6.00e-149 520.00
IUUC-Gac-041528 Gasterosteus aculeatus 41.18 8.00e-33 134.00
IUUC-Ggo-044948 Gorilla gorilla 80.08 0.00e+00 669.00
IUUC-Hsa-046376 Homo sapiens 84.96 0.00e+00 751.00
IUUC-Itr-048328 Ictidomys tridecemlineatus 84.62 0.00e+00 704.00
IUUC-Lch-050037 Latimeria chalumnae 55.17 3.00e-110 392.00
IUUC-Loc-051837 Lepisosteus oculatus 48.89 6.00e-107 380.00
IUUC-Mcc-055294 Macaca mulatta 85.16 0.00e+00 752.00
IUUC-Mga-060007 Meleagris gallopavo 64.02 3.00e-136 478.00
IUUC-Mmr-060673 Microcebus murinus 85.98 0.00e+00 761.00
IUUC-Mdo-063057 Monodelphis domestica 73.13 0.00e+00 638.00
IUUC-Mmu-063207 Mus musculus 75.86 3.00e-173 601.00
IUUC-Mpu-065836 Mustela putorius furo 85.77 0.00e+00 740.00
IUUC-Mlu-068193 Myotis lucifugus 84.24 0.00e+00 716.00
IUUC-Nle-069927 Nomascus leucogenys 84.96 0.00e+00 751.00
IUUC-Opr-070590 Ochotona princeps 78.25 0.00e+00 635.00
IUUC-Ont-071984 Oreochromis niloticus 39.39 3.00e-74 272.00
IUUC-Oan-072744 Ornithorhynchus anatinus 69.46 2.00e-156 545.00
IUUC-Ocu-074071 Oryctolagus cuniculus 86.44 0.00e+00 708.00
IUUC-Ola-087329 Oryzias latipes 40.33 2.00e-70 259.00
IUUC-Oga-088135 Otolemur garnettii 78.83 0.00e+00 702.00
IUUC-Oar-090078 Ovis aries 85.57 0.00e+00 755.00
IUUC-Ptr-091399 Pan troglodytes 84.96 0.00e+00 751.00
IUUC-Pan-092720 Papio anubis 85.16 0.00e+00 752.00
IUUC-Psi-093591 Pelodiscus sinensis 62.58 3.00e-128 451.00
IUUC-Pfo-096316 Poecilia formosa 41.21 9.00e-72 264.00
IUUC-Pab-097696 Pongo abelii 85.16 0.00e+00 748.00
IUUC-Pop-099579 Populus trichocarpa 38.89 9.00e-08 50.10
IUUC-Pca-100974 Procavia capensis 92.28 0.00e+00 881.00
IUUC-Pva-102488 Pteropus vampyrus 79.51 0.00e+00 676.00
IUUC-Rno-105641 Rattus norvegicus 77.19 5.00e-179 620.00
IUUC-Sha-107314 Sarcophilus harrisii 71.03 0.00e+00 649.00
IUUC-Sar-112938 Sorex araneus 80.28 0.00e+00 716.00
IUUC-Ssc-115495 Sus scrofa 87.40 0.00e+00 733.00
IUUC-Tgu-116623 Taeniopygia guttata 64.97 4.00e-142 497.00
IUUC-Tru-117820 Takifugu rubripes 37.90 1.00e-68 253.00
IUUC-Tsy-119162 Tarsius syrichta 61.75 1.00e-82 299.00
IUUC-Tni-119793 Tetraodon nigroviridis 43.36 8.00e-42 164.00
IUUC-Tbe-127816 Tupaia belangeri 68.72 2.00e-105 376.00
IUUC-Ttr-129194 Tursiops truncatus 77.56 0.00e+00 645.00
IUUC-Vpa-130326 Vicugna pacos 81.50 0.00e+00 660.00
IUUC-Xtr-132216 Xenopus tropicalis 54.18 5.00e-116 411.00
Created Date 25-Jun-2017

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