iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045412

UUCD1 version

UUC-GoG-01139

Ensembl Protein ID

ENSGGOP00000008916.2

UniProt Accession

G3R165; G3R165_GORGO

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000009115.2	ENSGGOT00000009162.2	ENSGGOP00000008916.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-19	69.2	525	911

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************99***************99998866777777777776 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++++       e      ++      ++  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDMQE------LEIP----QAYRGAGGSSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 682
           66677777778888999999999933......1111....12333467889*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLd 260
           +l+ p+ ++++k+  +  +++  k+   l+++ + +c++c+k+q + ++  +++lP++L+++    s +e+     +++ +v f+  + 
   Q: 683  TLSYPDGSKSDKTGKNYDFAQVLKRSIcLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFW--RMQAEVAFK--MA 767
           *****88888887655556665555542677778*****************************99977666555..588888887..56 PP
   S: 261  lspfcts........peekqke..............................................................kkkYe 279
           ++++  +                                                                              + Y+
   Q: 768  VKKHGGEisknkefaL-----AdwkelgspegvlvcpsieelknvwlpfsirmkmtknkgldvcnwtdgdemqwgparaeeehgVCVYD 851
           6666655333444440.....0555555555555555555555555555555555555566666666666666666666666669**** PP
   S: 280  LiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
           L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 852  LMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 911
           *********9*************999988877777888************9999888654 PP

Organism

Gorilla gorilla

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCTGATT GGAAGACGCG CCTCGGAGCC CGGTCCTTGG CGCCGTAGTG GTTAGGTTGA 60
GCCCTAGGCG TGGGGGAGAA CTGGGGAAAC TGGAATTTCC CGCGGAGCTG ACAGCGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

KEGG

ggo:101144172

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	98.17	0.00e+00	2354.00
IUUC-Apl-003500	Anas platyrhynchos	85.44	0.00e+00	1880.00
IUUC-Aca-004930	Anolis carolinensis	83.79	0.00e+00	2011.00
IUUC-Acl-008214	Aspergillus clavatus	31.25	5.00e-157	548.00
IUUC-Afu-009112	Aspergillus fumigatus	31.26	5.00e-147	515.00
IUUC-Ang-009531	Aspergillus niger	30.92	2.00e-149	523.00
IUUC-Ame-011259	Astyanax mexicanus	76.36	0.00e+00	1835.00
IUUC-Bta-012371	Bos taurus	97.67	0.00e+00	2341.00
IUUC-Bci-013684	Botrytis cinerea	31.31	3.00e-134	473.00
IUUC-Cja-019297	Callithrix jacchus	95.41	0.00e+00	2311.00
IUUC-Cfa-020489	Canis familiaris	97.25	0.00e+00	2321.00
IUUC-Cpo-022392	Cavia porcellus	96.67	0.00e+00	2347.00
IUUC-Csa-023220	Chlorocebus sabaeus	99.08	0.00e+00	2373.00
IUUC-Csv-025841	Ciona savignyi	45.25	0.00e+00	897.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	32.64	3.00e-163	569.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	6.00e-73	269.00
IUUC-Dre-028482	Danio rerio	74.17	0.00e+00	1784.00
IUUC-Dno-029398	Dasypus novemcinctus	97.09	0.00e+00	2311.00
IUUC-Dor-030307	Dipodomys ordii	90.13	0.00e+00	1316.00
IUUC-Dme-032111	Drosophila melanogaster	41.23	0.00e+00	882.00
IUUC-Eca-033985	Equus caballus	98.09	0.00e+00	2347.00
IUUC-Eeu-034928	Erinaceus europaeus	84.62	0.00e+00	778.00
IUUC-Fca-035587	Felis catus	98.25	0.00e+00	2359.00
IUUC-Fal-037587	Ficedula albicollis	84.32	0.00e+00	1979.00
IUUC-Fso-038133	Fusarium solani	29.40	1.00e-131	464.00
IUUC-Gmo-039076	Gadus morhua	73.72	0.00e+00	1745.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.12	8.00e-140	491.00
IUUC-Gga-040948	Gallus gallus	85.37	0.00e+00	2058.00
IUUC-Gac-042396	Gasterosteus aculeatus	74.32	0.00e+00	1797.00
IUUC-Hsa-046076	Homo sapiens	99.83	0.00e+00	2388.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.58	0.00e+00	2112.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	8.00e-67	248.00
IUUC-Lch-050279	Latimeria chalumnae	72.10	0.00e+00	1700.00
IUUC-Loc-052872	Lepisosteus oculatus	76.54	0.00e+00	1840.00
IUUC-Lma-052986	Leptosphaeria maculans	32.35	3.00e-157	549.00
IUUC-Laf-054181	Loxodonta africana	95.45	0.00e+00	2302.00
IUUC-Mcc-054812	Macaca mulatta	99.00	0.00e+00	2363.00
IUUC-Meu-056325	Macropus eugenii	92.35	0.00e+00	2214.00
IUUC-Mor-057246	Magnaporthe oryzae	29.18	6.00e-124	438.00
IUUC-Mpo-057464	Magnaporthe poae	31.69	2.00e-142	500.00
IUUC-Mla-058911	Melampsora laricipopulina	32.74	1.00e-100	361.00
IUUC-Mga-059335	Meleagris gallopavo	85.71	0.00e+00	2008.00
IUUC-Mvi-060461	Microbotryum violaceum	34.15	8.00e-145	508.00
IUUC-Mmr-060636	Microcebus murinus	98.59	0.00e+00	2356.00
IUUC-Mmu-063503	Mus musculus	95.53	0.00e+00	2274.00
IUUC-Mpu-066670	Mustela putorius furo	98.17	0.00e+00	2349.00
IUUC-Mlu-068119	Myotis lucifugus	96.76	0.00e+00	2357.00
IUUC-Nfi-068398	Neosartorya fischeri	31.85	1.00e-156	547.00
IUUC-Ncr-068927	Neurospora crassa	30.01	7.00e-130	458.00
IUUC-Nle-069651	Nomascus leucogenys	95.43	0.00e+00	2282.00
IUUC-Opr-070614	Ochotona princeps	96.85	0.00e+00	2305.00
IUUC-Ont-072433	Oreochromis niloticus	74.65	0.00e+00	1851.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.93	0.00e+00	1425.00
IUUC-Ocu-074401	Oryctolagus cuniculus	96.45	0.00e+00	2316.00
IUUC-Ola-087522	Oryzias latipes	74.30	0.00e+00	1796.00
IUUC-Oga-088226	Otolemur garnettii	97.03	0.00e+00	2338.00
IUUC-Oar-089241	Ovis aries	97.84	0.00e+00	2375.00
IUUC-Pan-092297	Papio anubis	99.06	0.00e+00	2113.00
IUUC-Psi-094043	Pelodiscus sinensis	82.16	0.00e+00	1921.00
IUUC-Pma-094394	Petromyzon marinus	69.43	0.00e+00	1562.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.80	2.00e-148	520.00
IUUC-Ppa-095188	Physcomitrella patens	32.46	3.00e-157	549.00
IUUC-Pfo-097517	Poecilia formosa	75.45	0.00e+00	1854.00
IUUC-Pca-100471	Procavia capensis	97.38	0.00e+00	2203.00
IUUC-Pva-102805	Pteropus vampyrus	93.50	0.00e+00	1849.00
IUUC-Pte-104021	Pyrenophora teres	31.89	1.00e-159	557.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	31.71	2.00e-158	553.00
IUUC-Rno-105471	Rattus norvegicus	95.59	0.00e+00	2274.00
IUUC-Sce-106235	Saccharomyces cerevisiae	39.18	8.00e-60	225.00
IUUC-Sha-106883	Sarcophilus harrisii	91.41	0.00e+00	2040.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.08	2.00e-142	500.00
IUUC-Sar-113323	Sorex araneus	95.64	0.00e+00	1718.00
IUUC-Sre-115075	Sporisorium reilianum	29.49	3.00e-69	257.00
IUUC-Ssc-116363	Sus scrofa	96.69	0.00e+00	2347.00
IUUC-Tru-118427	Takifugu rubripes	74.84	0.00e+00	1868.00
IUUC-Tni-120218	Tetraodon nigroviridis	75.10	0.00e+00	1863.00
IUUC-Tre-122177	Trichoderma reesei	31.69	3.00e-151	529.00
IUUC-Tme-127176	Tuber melanosporum	32.33	8.00e-140	491.00
IUUC-Tbe-127641	Tupaia belangeri	88.64	0.00e+00	808.00
IUUC-Ttr-128888	Tursiops truncatus	96.66	0.00e+00	1485.00
IUUC-Uma-129361	Ustilago maydis	38.42	2.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	78.92	0.00e+00	1895.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence